Deep Brain Stimulation for Treatment-Resistant Depression

Dr. Mayberg has a consulting agreement with St. Jude Medical, Inc., which has licensed her intellectual property to develop subcallosal cingulate deep brain stimulation for the treatment of severe depression (US 2005/0033379A1, co-inventor, Andres Lozano, M.D., Ph.D.). The terms of these arrangements have been reviewed and approved by Emory University in accordance with their confiict-of-interest policies. Dr. Mayberg has received grant funding from the Dana Foundation, NARSAD, NIMH, Stanley Medical Research Institute, and Wood-ruff Foundation. Dr. Holtzheimer has received grant funding from the Dana Foundation, Greenwall Foundation, NARSAD, NIMH (grant K23 MH077869), NIH Loan Repayment Program, Northstar, Inc., Stanley Medical Research Institute, and Woodruff Foundation and has received consulting fees from AvaCat Consulting, St. Jude Medical Neuromodulation, and Oppenheimer & Co.The patient case described in this case was part of an experimental research protocol at Emory University funded by the Woodruff Fund and the Dana Foundation under a physician-sponsored Investigational Device Exemption (FDA IDE G060028/S002); the clinical trial is registered at clinicaltrials.gov (NCT00367003). St. Jude Medical has no involvement in the design, acquisition, analysis, or interpretation of experimental data of these studies. Dr. Mayberg, while principal investigator of the research, does not participate in patient recruitment, obtaining patient consent, outcome assessments, or primary data analysis, as outlined in a confiict-of-interest management plan set up at Emory.