Pediatric-Onset and Adult-Onset Separation Anxiety Disorder Across Countries in the World Mental Health Survey
Abstract
Objective:
Method:
Results:
Conclusions:
Method
Samples
Measures
Overview.
Diagnostic assessment.
Sociodemographic variables.
Functional Impairment.
Childhood family adversities.
Traumatic events.
Analysis Procedures
Results
Prevalence
Country and Country Income | Lifetime Prevalence | 12-Month Prevalence | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Total | Male | Female | Total | Male | Female | Sample Size (N) | ||||||||
% | SE | % | SE | % | SE | % | SE | % | SE | % | SE | Male | Female | |
All countries | 4.8 | 0.1 | 4.0 | 0.2 | 5.6* | 0.2 | 1.0 | 0.1 | 0.8 | 0.1 | 1.3* | 0.1 | 16,869 | 22,124 |
Low-/lower-middle income | 5.5 | 0.4 | 4.5 | 0.4 | 6.4* | 0.5 | 1.3 | 0.2 | 0.9 | 0.2 | 1.7 | 0.4 | 2,622 | 3,472 |
Colombia | 9.8 | 0.8 | 8.1 | 1.1 | 11.3* | 1.2 | 2.7 | 0.5 | 1.9 | 0.5 | 3.3 | 0.9 | 885 | 1,496 |
Nigeria | 0.2 | 0.1 | 0.2 | 0.1 | 0.2 | 0.2 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 614 | 675 |
People’s Republic of China-Beijing/Shanghai | 1.3 | 0.5 | 0.7 | 0.4 | 2.1 | 1.0 | 0.2 | 0.1 | 0.0 | 0.0 | 0.4 | 0.2 | 326 | 297 |
Peru | 6.1 | 0.7 | 5.6 | 0.8 | 6.6 | 0.9 | 1.2 | 0.2 | 0.9 | 0.2 | 1.4 | 0.3 | 797 | 1,004 |
Upper-middle income | 4.7 | 0.2 | 4.0 | 0.3 | 5.3* | 0.3 | 1.2 | 0.1 | 1.0 | 0.2 | 1.4 | 0.2 | 5,334 | 7,271 |
Brazil | 7.7 | 0.4 | 6.7 | 0.6 | 8.6* | 0.6 | 2.0 | 0.3 | 1.7 | 0.4 | 2.3 | 0.3 | 2,187 | 2,850 |
Bulgaria | 1.4 | 0.4 | 1.5 | 0.8 | 1.2 | 0.3 | 0.4 | 0.3 | 0.6 | 0.5 | 0.2 | 0.1 | 951 | 1,282 |
Lebanon | 6.9 | 1.3 | 4.9 | 1.5 | 9.0 | 1.8 | 1.9 | 0.5 | 1.1 | 0.5 | 2.7 | 0.8 | 251 | 365 |
Mexico | 4.5 | 0.4 | 3.7 | 0.8 | 5.2 | 0.5 | 0.9 | 0.2 | 0.7 | 0.2 | 1.1 | 0.2 | 853 | 1,509 |
Romania | 0.9 | 0.3 | 0.9 | 0.4 | 0.9 | 0.3 | 0.3 | 0.1 | 0.2 | 0.1 | 0.3 | 0.2 | 1,092 | 1,265 |
High-income | 4.7 | 0.2 | 3.7 | 0.2 | 5.6* | 0.3 | 0.9 | 0.1 | 0.7 | 0.1 | 1.0 | 0.1 | 8,913 | 11,381 |
Belgium | 1.4 | 0.3 | 0.7 | 0.3 | 2.1* | 0.4 | 0.1 | 0.1 | 0.0 | 0.0 | 0.3 | 0.2 | 599 | 591 |
France | 3.5 | 0.5 | 3.1 | 0.7 | 3.9 | 1.0 | 0.9 | 0.3 | 0.4 | 0.2 | 1.4 | 0.7 | 692 | 772 |
Germany | 2.0 | 0.4 | 1.5 | 0.4 | 2.6 | 0.6 | 0.4 | 0.2 | 0.5 | 0.3 | 0.4 | 0.3 | 806 | 912 |
Italy | 1.5 | 0.4 | 0.6 | 0.3 | 2.3* | 0.5 | 0.0 | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 | 1,171 | 1,209 |
The Netherlands | 3.0 | 0.6 | 2.0 | 0.8 | 4.0 | 1.1 | 0.6 | 0.3 | 0.5 | 0.3 | 0.7 | 0.6 | 472 | 637 |
Northern Ireland | 5.1 | 0.5 | 5.1 | 0.8 | 5.2 | 0.6 | 0.4 | 0.1 | 0.5 | 0.2 | 0.4 | 0.1 | 822 | 1,164 |
Portugal | 6.4 | 0.8 | 5.7 | 1.5 | 7.2 | 0.7 | 1.2 | 0.3 | 0.8 | 0.4 | 1.5 | 0.4 | 759 | 1,301 |
Spain | 1.2 | 0.3 | 1.1 | 0.4 | 1.4 | 0.4 | 0.3 | 0.1 | 0.1 | 0.1 | 0.4 | 0.2 | 1,210 | 1,485 |
United States | 9.2 | 0.4 | 7.4 | 0.5 | 10.8* | 0.6 | 1.9 | 0.2 | 1.7 | 0.3 | 2.1 | 0.2 | 2,382 | 3,310 |
Age at Onset
Persistence
Disorder | Temporally Primary Separation Anxiety Disorder Predicting Subsequent Onset and Persistence of Other Disorders | Temporally Primary Other Disorders Predicting Subsequent Onset and Persistence of Separation Anxiety Disorder | ||||||
---|---|---|---|---|---|---|---|---|
Onseta | Persistenceb | Onsetc | Persistenced | |||||
Odds Ratio | 95% CI | Odds Ratio | 95% CI | Odds Ratio | 95% CI | Odds Ratio | 95% CI | |
Internalizing | ||||||||
Major depressive disorder | 1.4* | 1.3–1.6 | 1.3* | 1.1–1.7 | 1.7* | 1.4–2.0 | 1.4 | 0.9–2.1 |
Bipolar disorder | 1.8* | 1.4–2.3 | 1.3 | 0.8–2.2 | 1.9* | 1.4–2.4 | 1.6 | 0.9–2.7 |
Panic disorder without agoraphobia | 1.3* | 1.0–1.7 | 1.0 | 0.6–1.8 | 1.8* | 1.4–2.2 | 1.4 | 0.8–2.5 |
Generalized anxiety disorder | 1.5* | 1.2–1.9 | 1.4 | 1.0–1.9 | 1.1 | 0.8–1.6 | 0.9 | 0.5–1.6 |
Posttraumatic stress disorder | 1.6* | 1.3–2.1 | 1.8* | 1.2–2.6 | 0.9 | 0.7–1.2 | 0.9 | 0.5–1.6 |
Social phobia | 1.6* | 1.2–2.0 | 1.2 | 0.8–1.7 | 1.4* | 1.2–1.7 | 1.3 | 0.9–2.0 |
Specific phobia | 1.7* | 1.2–2.2 | 1.3 | 0.7–2.5 | 2.1* | 1.8–2.4 | 1.0 | 0.7–1.4 |
Agoraphobia with or without panic | 1.2 | 0.9–1.6 | 2.6* | 1.4–4.7 | 1.3 | 0.9–1.8 | 1.1 | 0.6–1.9 |
Externalizing | ||||||||
Attention deficit hyperactivity disorder | 2.8* | 1.6–4.6 | 0.8 | 0.4–1.9 | 1.1 | 0.8–1.5 | 1.2 | 0.7–2.0 |
Oppositional defiant disorder | 1.6* | 1.1–2.6 | 1.0 | 0.4–2.3 | 1.7* | 1.3–2.2 | 1.4 | 0.8–2.4 |
Conduct disorder | 1.4* | 1.0–1.8 | 0.7 | 0.3–1.4 | 1.4* | 1.1–1.9 | 0.8 | 0.4–1.6 |
Intermittent explosive disorder | 1.3 | 1.0–1.7 | 0.7 | 0.5–1.2 | 1.3* | 1.0–1.7 | 0.8 | 0.5–1.4 |
Substance abuse with or without dependence | 1.0 | 0.8–1.2 | 1.3 | 0.9–1.8 | 1.4* | 1.0–1.9 | 0.8 | 0.5–1.5 |
Substance dependence with abuse | 1.0 | 0.8–1.4 | 1.3 | 0.8–2.1 | 1.0 | 0.7–1.4 | 1.0 | 0.4–2.2 |
Comorbidity
Other Predictors of Separation Anxiety Disorder Onset and Persistence
Variable | Total Sample | Childhood (Age 13) | Adolescence (Ages 13–17) | Early Adulthood (Ages 18–29) | Later Adulthood (Ages ≥30) | |||||
---|---|---|---|---|---|---|---|---|---|---|
Odds Ratio | 95% CI | Odds Ratio | 95% CI | Odds Ratio | 95% CI | Odds Ratio | 95% CI | Odds Ratio | 95% CI | |
Sex | ||||||||||
Female | 1.3* | 1.2–1.5 | 1.4* | 1.1–1.7 | 1.1 | 0.8–1.5 | 1.4* | 1.1–1.9 | 1.1 | 0.7–1.7 |
Male (reference) | 1.0 | – | 1.0 | – | 1.0 | – | 1.0 | – | 1.0 | – |
Educationb | ||||||||||
Student | 1.2 | 1.0–1.6 | – | – | – | – | 1.0 | 0.6–1.5 | ||
Low | 1.5* | 1.2–2.0 | – | – | – | – | 1.4 | 1.0–2.2 | 2.0* | 1.3–3.2 |
Low-average | 1.6* | 1.2–2.0 | – | – | – | – | 1.4 | 1.0–2.0 | 2.0* | 1.2–3.3 |
High-average | 1.7* | 1.3–2.1 | 1.4 | 1.0–1.9 | 1.8* | 1.2–2.7 | ||||
High (reference) | 1.0 | – | 1.0 | – | 1.0 | – | 1.0 | – | 1.0 | – |
Marital Statusc | ||||||||||
Never married | 1.1 | 0.9–1.4 | – | – | – | – | 0.9 | 0.7–1.1 | 1.2 | 0.8–1.8 |
Previously married | 1.3 | 0.9–1.8 | – | – | – | – | 1.6* | 1.1–2.3 | 1.7* | 1.1–2.5 |
Currently married (reference) | 1.0 | – | 1.0 | – | 1.0 | – | 1.0 | – | 1.0 | – |
Number of maladaptive family functioning childhood adversitiesd, e | ||||||||||
1 | 1.7* | 1.4–2.0 | 1.7* | 1.3–2.2 | 1.2 | 0.8–1.8 | 1.6* | 1.2–2.1 | 2.1* | 1.2–3.7 |
2 | 2.0* | 1.6–2.4 | 2.3* | 1.7–3.1 | 1.4 | 0.8–2.4 | 1.7* | 1.2–2.3 | 2.0* | 1.1–3.4 |
3 | 2.3* | 1.8–2.8 | 2.6* | 1.8–3.7 | 2.1* | 1.3–3.4 | 1.7* | 1.2–2.5 | 2.0* | 1.1–3.4 |
4 | 2.8* | 2.0–4.0 | 3.0* | 1.9–5.0 | 1.7 | 0.8–3.6 | 3.3* | 1.6–6.8 | 1.9* | 1.0–3.8 |
≥5 | 2.8* | 2.1–3.6 | 3.7* | 2.3–6.0 | 1.0 | 0.4–2.5 | 2.5* | 1.3–4.6 | 3.7* | 1.5–9.1 |
None (reference) | 1.0 | – | 1.0 | – | 1.0 | – | 1.0 | – | 1.0 | – |
Number of other childhood adversitiesf | ||||||||||
1 | 1.3* | 1.1–1.5 | 1.5* | 1.2–1.9 | 1.3 | 0.9–1.9 | 1.0 | 0.8–1.3 | 1.1 | 0.7–1.5 |
2 | 1.2 | 1.0–1.5 | 1.7* | 1.2–2.3 | 1.2 | 0.7–2.1 | 0.8 | 0.6–1.2 | 1.0 | 0.6–1.7 |
≥3 | 1.8* | 1.3–2.4 | 2.8* | 1.6–4.9 | 1.4 | 0.6–3.6 | 1.3 | 0.7–2.3 | 0.5 | 0.2–1.5 |
None (Reference) | 1.0 | – | 1.0 | – | 1.0 | – | 1.0 | – | 1.0 | – |
Lifetime traumag | ||||||||||
War | 1.1 | 0.9–1.3 | 1.6* | 1.0–2.5 | 1.4 | 0.7–2.5 | 0.9 | 0.6–1.3 | 1.0 | 0.6–1.5 |
Violence | 1.1 | 0.9–1.2 | 2.0* | 1.2–3.3 | 0.8 | 0.5–1.2 | 1.2 | 0.9–1.5 | 0.8 | 0.5–1.1 |
Sexual violence | 1.6* | 1.3–1.9 | 2.8 | 0.6–12.3 | 3.0* | 1.5–5.8 | 1.6* | 1.2–2.1 | 1.5* | 1.0–2.1 |
Accident | 1.4* | 1.1–1.6 | 1.1 | 0.7–1.7 | 1.8* | 1.2–2.6 | 1.3* | 1.0–1.7 | 1.5* | 1.0–2.3 |
Family death | 1.4* | 1.2–1.6 | 1.7* | 1.1–2.5 | 1.3 | 0.8–2.0 | 1.3* | 1.0–1.6 | 1.6* | 1.2–2.3 |
Network events | 1.3* | 1.1–1.6 | 1.6 | 0.9–2.9 | 1.5* | 1.0–2.2 | 1.3* | 1.0–1.7 | 1.1 | 0.8–1.5 |
Other | 1.5* | 1.2–1.9 | 1.9* | 1.1–3.3 | 1.7* | 1.0–3.00 | 1.2 | 0.8–1.8 | 2.0* | 1.3–3.3 |
Role Impairment of 12-Month Separation Anxiety Disorder
Country Income and Age at Onset | Total | With Comorbidity | Without Comorbidity | |||
---|---|---|---|---|---|---|
% | SE | % | SE | % | SE | |
Total sample | ||||||
4–12 years old | 33.9 | 5.2 | 37.3 | 5.9 | 8.5 | 8.2 |
13–17 years old | 42.2 | 7.5 | 46.5 | 8.5 | 23.7 | 10.8 |
18–29 years old | 35.7 | 4.3 | 45.3 | 5.3 | 16.7 | 5.3 |
≥30 years old | 31.7 | 5.8 | 40.4 | 7.3 | 21.2 | 8.9 |
Total | 35.3 | 2.5 | 42.4 | 2.9 | 18.3 | 4.3 |
Low-/lower-middle income countries | ||||||
4–12 years old | 24.0 | 12.2 | 24.7 | 12.7 | 0.0 | 0.0 |
13–17 years old | 14.5 | 7.9 | 13.0 | 8.7 | 19.4 | 18.8 |
18–29 years old | 19.8 | 5.8 | 32.2 | 8.5 | 8.5 | 5.7 |
≥30 years old | 9.0 | 5.4 | 19.5 | 10.5 | 0.0 | 0.0 |
Total | 17.6 | 4.1 | 25.3 | 6.0 | 6.9 | 3.8 |
Upper-middle income countries | ||||||
4–12 years old | 38.4 | 10.6 | 38.5 | 11.3 | 36.8 | 26.3 |
13–17 years old | 30.6 | 10.7 | 27.8 | 13.1 | 39.3 | 17.0 |
18–29 years old | 44.6 | 8.0 | 47.9 | 10.5 | 35.0 | 12.2 |
≥30 years old | 35.4 | 9.1 | 46.8 | 10.5 | 26.0 | 13.9 |
Total | 38.2 | 4.1 | 41.6 | 4.4 | 30.6 | 8.9 |
High-income countries | ||||||
4–12 years old | 33.6 | 6.1 | 40.5 | 7.0 | 0.0 | 0.0 |
13–17 years old | 62.3 | 10.5 | 71.1 | 9.2 | 0.0 | 0.0 |
18–29 years old | 39.8 | 6.4 | 49.1 | 7.6 | 14.7 | 7.7 |
≥30 years old | 38.1 | 10.4 | 41.6 | 12.5 | 28.9 | 16.9 |
Total | 41.4 | 3.8 | 49.3 | 4.3 | 14.2 | 5.7 |
Discussion
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