American Journal of Psychiatry

Objective:How long clinicians should wait before considering an antipsychotic ineffective and changing treatment in schizophrenia is an unresolved clinical question. Guidelines differ substantially in this regard. The authors conducted a diagnostic test ...

https://doi.org/10.1176/appi.ajp.2015.14101329

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The Intergenerational Transmission of Anxiety: A Children-of-Twins Study

Publication date: 23 April 2015

Pages630–637

Objective:The transmission of anxiety within families is well recognized, but the underlying processes are poorly understood. Twin studies of adolescent anxiety demonstrate both genetic and environmental influence, and multiple aspects of parenting are ...

https://doi.org/10.1176/appi.ajp.2015.14070818

Diagnostic Precursors to Bipolar Disorder in Offspring of Parents With Bipolar Disorder: A Longitudinal Study

Publication date: 03 March 2015

Pages638–646

Objective:The authors sought to identify diagnostic risk factors of manic, mixed, or hypomanic episodes in the offspring of parents with bipolar disorder (“high-risk offspring”).Method:High-risk offspring 6–18 years old (N=391) and demographically matched ...

https://doi.org/10.1176/appi.ajp.2014.14010035

Pediatric-Onset and Adult-Onset Separation Anxiety Disorder Across Countries in the World Mental Health Survey

Publication date: 05 June 2015

Pages647–656

Objective:The age-at-onset criterion for separation anxiety disorder was removed in DSM-5, making it timely to examine the epidemiology of separation anxiety disorder as a disorder with onsets spanning the life course, using cross-country data.Method:The ...

https://doi.org/10.1176/appi.ajp.2015.14091185

Longitudinal Stability of Genetic and Environmental Influences on Irritability: From Childhood to Young Adulthood

Publication date: 23 April 2015

Pages657–664

Objective:Little is known about genetic influences on juvenile irritability and whether such influences are developmentally stable and/or dynamic. This study examined the temporal pattern of genetic and environmental effects on irritability using data ...

https://doi.org/10.1176/appi.ajp.2015.14040509

Overactive Performance Monitoring as an Endophenotype for Obsessive-Compulsive Disorder: Evidence From a Treatment Study

Publication date: 17 March 2015

Pages665–673

Objective:Overactive performance monitoring, as measured by the error-related negativity in the event-related brain potential, represents one of the most robust psychophysiological alterations in obsessive-compulsive disorder (OCD). It has been proposed ...

https://doi.org/10.1176/appi.ajp.2014.14070886

Distinguishing Adolescents With ADHD From Their Unaffected Siblings and Healthy Comparison Subjects by Neural Activation Patterns During Response Inhibition

Publication date: 23 January 2015

Pages674–683

Objective:Dysfunctional response inhibition is a key executive function impairment in attention deficit hyperactivity disorder (ADHD). Still, behavioral response inhibition measures do not consistently differentiate affected from unaffected individuals. ...

https://doi.org/10.1176/appi.ajp.2014.13121635