American Journal of Psychiatry

Anxiety disorders are common in adolescents (ages 12 to 18) and contribute to a range of impairments. There has been speculation that adolescents with anxiety are at risk for being treatment nonresponders. In this review, the authors examine the efficacy ...

https://doi.org/10.1176/appi.ajp.2015.14081061

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Brain Development in Heavy-Drinking Adolescents

Publication date: 18 May 2015

Pages531–542

Objective:Heavy alcohol use during adolescence may alter the trajectory of normal brain development. The authors measured within-subject changes in regional brain morphometry over longer intervals and in larger samples of adolescents than previously ...

https://doi.org/10.1176/appi.ajp.2015.14101249

Association of Protein Phosphatase PPM1G With Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis

Publication date: 18 May 2015

Pages543–552

Objective:The genetic component of alcohol use disorder is substantial, but monozygotic twin discordance indicates a role for nonheritable differences that could be mediated by epigenetics. Despite growing evidence associating epigenetics and psychiatric ...

https://doi.org/10.1176/appi.ajp.2014.14030382

Triparental Families: A New Genetic-Epidemiological Design Applied to Drug Abuse, Alcohol Use Disorders, and Criminal Behavior in a Swedish National Sample

Publication date: 20 February 2015

Pages553–560

Objective:The authors sought to clarify the sources of parent-offspring resemblance for drug abuse, alcohol use disorders, and criminal behavior, using a novel genetic-epidemiological design.Method:Using national registries, the authors identified rates ...

https://doi.org/10.1176/appi.ajp.2014.14091127

Citalopram, Methylphenidate, or Their Combination in Geriatric Depression: A Randomized, Double-Blind, Placebo-Controlled Trial

Publication date: 13 February 2015

Pages561–569

Objective:The authors evaluated the potential of methylphenidate to improve antidepressant response to citalopram, as assessed by clinical and cognitive outcomes, in elderly depressed patients.Method:The authors conducted a 16-week randomized double-blind ...

https://doi.org/10.1176/appi.ajp.2014.14070889

Cerebral Small Vessel Disease and Association With Higher Incidence of Depressive Symptoms in a General Elderly Population: The AGES-Reykjavik Study

Publication date: 03 March 2015

Pages570–578

Objective:The vascular depression hypothesis postulates that cerebral small vessel disease (CSVD) leads to depressive symptoms by disruption of brain structures involved in mood regulation. However, longitudinal data on the association between CSVD and ...

https://doi.org/10.1176/appi.ajp.2014.14050578

Prediction of Working Memory Performance in Schizophrenia by Plasma Ratio of Clozapine to N-Desmethylclozapine

Publication date: 10 April 2015

Pages579–585

Objective:Clozapine’s potent antagonism of muscarinic M₁ receptors is thought to worsen working memory deficits associated with schizophrenia. In contrast, its major metabolite, N-desmethylclozapine (NDMC), is thought to enhance working memory via its M₁ ...

https://doi.org/10.1176/appi.ajp.2015.14050673