American Journal of Psychiatry
- Volume 172
- Number 6
- June 2015
Perspectives
Editorials
Perspectives
Introspection
Perspectives
Clinical Case Conference
Perspectives
Images in Psychiatry
Review and Overviews
Publication date: 01 June 2015
Pages519–530Anxiety disorders are common in adolescents (ages 12 to 18) and contribute to a range of impairments. There has been speculation that adolescents with anxiety are at risk for being treatment nonresponders. In this review, the authors examine the efficacy ...
https://doi.org/10.1176/appi.ajp.2015.14081061New Research
Articles
Publication date: 18 May 2015
Pages531–542Objective: Heavy alcohol use during adolescence may alter the trajectory of normal brain development. The authors measured within-subject changes in regional brain morphometry over longer intervals and in larger samples of adolescents than previously ...
https://doi.org/10.1176/appi.ajp.2015.14101249Publication date: 18 May 2015
Pages543–552Objective: The genetic component of alcohol use disorder is substantial, but monozygotic twin discordance indicates a role for nonheritable differences that could be mediated by epigenetics. Despite growing evidence associating epigenetics and psychiatric ...
https://doi.org/10.1176/appi.ajp.2014.14030382Publication date: 20 February 2015
Pages553–560Objective: The authors sought to clarify the sources of parent-offspring resemblance for drug abuse, alcohol use disorders, and criminal behavior, using a novel genetic-epidemiological design. Method: Using national registries, the authors identified rates ...
https://doi.org/10.1176/appi.ajp.2014.14091127Publication date: 13 February 2015
Pages561–569Objective: The authors evaluated the potential of methylphenidate to improve antidepressant response to citalopram, as assessed by clinical and cognitive outcomes, in elderly depressed patients. Method: The authors conducted a 16-week randomized double-blind ...
https://doi.org/10.1176/appi.ajp.2014.14070889Publication date: 03 March 2015
Pages570–578Objective: The vascular depression hypothesis postulates that cerebral small vessel disease (CSVD) leads to depressive symptoms by disruption of brain structures involved in mood regulation. However, longitudinal data on the association between CSVD and ...
https://doi.org/10.1176/appi.ajp.2014.14050578Publication date: 10 April 2015
Pages579–585Objective: Clozapine’s potent antagonism of muscarinic M1 receptors is thought to worsen working memory deficits associated with schizophrenia. In contrast, its major metabolite, N-desmethylclozapine (NDMC), is thought to enhance working memory via its M1 ...
https://doi.org/10.1176/appi.ajp.2015.14050673Communications and Updates
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Communications and Updates
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