American Journal of Psychiatry

The major classes of psychotropic drugs were introduced in an extraordinary decade of discovery between the late 1940s and late 1950s. In the present climate of pessimism about the absence of new drug development, it may be instructive to look back at the ...

https://doi.org/10.1176/appi.ajp.2015.14101336

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Is Exposure Necessary? A Randomized Clinical Trial of Interpersonal Psychotherapy for PTSD

Publication date: 13 February 2015

Pages430–440

Objective:Exposure to trauma reminders has been considered imperative in psychotherapy for posttraumatic stress disorder (PTSD). The authors tested interpersonal psychotherapy (IPT), which has demonstrated antidepressant efficacy and shown promise in ...

https://doi.org/10.1176/appi.ajp.2014.14070908

Brief Cognitive-Behavioral Therapy Effects on Post-Treatment Suicide Attempts in a Military Sample: Results of a Randomized Clinical Trial With 2-Year Follow-Up

Publication date: 13 February 2015

Pages441–449

Objective:The authors evaluated the effectiveness of brief cognitive-behavioral therapy (CBT) for the prevention of suicide attempts in military personnel.Method:In a randomized controlled trial, active-duty Army soldiers at Fort Carson, Colo., who either ...

https://doi.org/10.1176/appi.ajp.2014.14070843

Treatment of Maternal Depression in a Medication Clinical Trial and Its Effect on Children

Publication date: 23 January 2015

Pages450–459

Objective:Observational studies show that when a depressed mother’s symptoms remit, her children’s psychiatric symptoms decrease. Using randomized treatment assignment, the authors sought to determine the differential effects of a depressed mother’s ...

https://doi.org/10.1176/appi.ajp.2014.13121679

Neuropsychiatric Symptoms as Predictors of Progression to Severe Alzheimer’s Dementia and Death: The Cache County Dementia Progression Study

Publication date: 13 January 2015

Pages460–465

Objective:Little is known about factors influencing the rate of progression of Alzheimer’s dementia. Using data from the Cache County Dementia Progression Study, the authors examined the link between clinically significant neuropsychiatric symptoms in ...

https://doi.org/10.1176/appi.ajp.2014.14040480

Genetic Sources of Subcomponents of Event-Related Potential in the Dimension of Psychosis Analyzed From the B-SNIP Study

Publication date: 23 January 2015

Pages466–478

Objective:Biological risk factors underlying psychosis are poorly understood. Biological underpinnings of the dimension of psychosis can be derived using genetic associations with intermediate phenotypes such as subcomponents of auditory event-related ...

https://doi.org/10.1176/appi.ajp.2014.13101411

Cortical Morphology in 6- to 10-Year Old Children With Autistic Traits: A Population-Based Neuroimaging Study

Publication date: 13 January 2015

Pages479–486

Objective:Recent evidence suggests that symptoms of social impairment in autism spectrum disorder (ASD) form a spectrum that extends into the general population. However, it is unclear whether the neuroanatomy of ASD also shows a similar continuum in the ...

https://doi.org/10.1176/appi.ajp.2014.14040482