American Journal of Psychiatry

Objective: The limitations of the DSM nosology for capturing dimensionality and overlap in psychiatric syndromes, and its poor correspondence to underlying neurobiology, have been well established. The Research Domain Criteria (RDoC), a proposed ...

https://doi.org/10.1176/appi.ajp.2014.14091177

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Perspectives

Images in Psychiatry

Charles Darwin and the Asylum Letters

Malcolm King, M.S., R.N.

Publication date: 31 March 2015

Pages321–322https://doi.org/10.1176/appi.ajp.2014.14101260

Perspectives

Reviews and Overviews

Modifiable Predictors of Dementia in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

Publication date: 20 February 2015

Pages323–334

Objective: Public health campaigns encouraging early help seeking have increased rates of mild cognitive impairment (MCI) diagnosis in Western countries, but we know little about how to treat or predict dementia outcomes in persons with the condition. ...

https://doi.org/10.1176/appi.ajp.2014.14070878

New Research

Articles

Effects of Cognitive Bias Modification Training on Neural Alcohol Cue Reactivity in Alcohol Dependence

Publication date: 19 December 2014

Pages335–343

Objective: In alcohol-dependent patients, alcohol cues evoke increased activation in mesolimbic brain areas, such as the nucleus accumbens and the amygdala. Moreover, patients show an alcohol approach bias, a tendency to more quickly approach than avoid ...

https://doi.org/10.1176/appi.ajp.2014.13111495

Pragmatic Replication Trial of Health Promotion Coaching for Obesity in Serious Mental Illness and Maintenance of Outcomes

Publication date: 12 December 2014

Pages344–352

Objective: Few studies targeting obesity in serious mental illness have reported clinically significant risk reduction, and none have been replicated in community settings or demonstrated sustained outcomes after intervention withdrawal. The authors sought ...

https://doi.org/10.1176/appi.ajp.2014.14030357

Association of CRP Genetic Variation and CRP Level With Elevated PTSD Symptoms and Physiological Responses in a Civilian Population With High Levels of Trauma

Publication date: 12 December 2014

Pages353–362

Objective: Increased systemic inflammation is associated with stress-related psychopathology. Specifically, levels of the proinflammatory marker C-reactive protein (CRP) are elevated in individuals with posttraumatic stress disorder (PTSD). Furthermore, ...

https://doi.org/10.1176/appi.ajp.2014.14020263

Validation of Electronic Health Record Phenotyping of Bipolar Disorder Cases and Controls

Publication date: 12 December 2014

Pages363–372

Objective: The study was designed to validate use of electronic health records (EHRs) for diagnosing bipolar disorder and classifying control subjects. Method: EHR data were obtained from a health care system of more than 4.6 million patients spanning more ...

https://doi.org/10.1176/appi.ajp.2014.14030423

Synaptic Proteins in the Hippocampus Indicative of Increased Neuronal Activity in CA3 in Schizophrenia

Publication date: 13 January 2015

Pages373–382

Objective: In schizophrenia, hippocampal perfusion is increased and declarative memory function is degraded. Based on an a priori model of hippocampal dysfunction in schizophrenic psychosis, the authors postulated molecular and cellular changes in CA3 ...

https://doi.org/10.1176/appi.ajp.2014.14010123

Reward-Based Spatial Learning in Unmedicated Adults With Obsessive-Compulsive Disorder

Publication date: 19 December 2014

Pages383–392

Objective: The authors assessed the functioning of mesolimbic and striatal areas involved in reward-based spatial learning in unmedicated adults with obsessive-compulsive disorder (OCD). Method: Functional MRI blood-oxygen-level-dependent response was ...

https://doi.org/10.1176/appi.ajp.2014.13121700