American Journal of Psychiatry

Objective:In this conceptual review, the authors propose a novel mechanistic candidate in the etiology of depression with onset in the menopause transition (“perimenopausal depression”) involving alterations in stress-responsive pathways, induced by ...

https://doi.org/10.1176/appi.ajp.2014.14070918

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Prescription Practices in the Treatment of First-Episode Schizophrenia Spectrum Disorders: Data From the National RAISE-ETP Study

Publication date: 04 December 2014

Pages237–248

Objective:Treatment guidelines suggest distinctive medication strategies for first-episode and multiepisode patients with schizophrenia. To assess the extent to which community clinicians adjust their usual treatment regimens for first-episode patients, ...

https://doi.org/10.1176/appi.ajp.2014.13101355

Outcomes of Nontransitioned Cases in a Sample at Ultra-High Risk for Psychosis

Publication date: 01 March 2015

Pages249–258

Objective:Two-thirds of individuals identified as at ultra-high risk for psychosis do not develop psychotic disorder over the medium term. The authors examined outcomes in a group of such patients.Method:Participants were help-seeking individuals ...

https://doi.org/10.1176/appi.ajp.2014.13030418

IQ and Schizophrenia in a Swedish National Sample: Their Causal Relationship and the Interaction of IQ With Genetic Risk

Publication date: 01 March 2015

Pages259–265

Objective:The authors sought to clarify the relationship between IQ and subsequent risk for schizophrenia.Method:IQ was assessed at ages 18–20 in 1,204,983 Swedish males born between 1951 and 1975. Schizophrenia was assessed by hospital diagnosis through ...

https://doi.org/10.1176/appi.ajp.2014.14040516

Social Responsiveness, an Autism Endophenotype: Genomewide Significant Linkage to Two Regions on Chromosome 8

Publication date: 01 March 2015

Pages266–275

Objective:Autism spectrum disorder is characterized by deficits in social function and the presence of repetitive and restrictive behaviors. Following a previous test of principle, the authors adopted a quantitative approach to discovering genes ...

https://doi.org/10.1176/appi.ajp.2014.14050576

Developmental Change in Amygdala Reactivity During Adolescence: Effects of Family History of Depression and Stressful Life Events

Publication date: 19 December 2014

Pages276–283

Objective:Although heightened amygdala reactivity is observed in patients with major depression, two critical gaps in our knowledge remain. First, it is unclear whether heightened amygdala reactivity is a premorbid vulnerability or a consequence of the ...

https://doi.org/10.1176/appi.ajp.2014.14020195

Functional Neuroimaging of Avoidance Habits in Obsessive-Compulsive Disorder

Publication date: 19 December 2014

Pages284–293

Objective:The purpose of this study was to determine the neural correlates of excessive habit formation in obsessive-compulsive disorder (OCD). The authors aimed to test for neurobiological convergence with the known pathophysiology of OCD and to infer, ...

https://doi.org/10.1176/appi.ajp.2014.14040525