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Published Online: 1 December 2020

The Case for Cautious Interpretation and Replication: Lead-Time Bias as a Potential Explanation for the Link Between Duration of Untreated Psychosis and Outcome

Srividya N. Iyer, Ph.D. [email protected], Kelly K. Anderson, Ph.D., Ashok Malla, M.B.B.S., F.R.C.P.(C.), Jai Shah, M.D., F.R.C.P.(C.), and Ross Norman, Ph.D.Authors Info & Affiliations
Publication: American Journal of Psychiatry
Volume 177, Number 12
https://doi.org/10.1176/appi.ajp.2020.20030299
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Information & Authors

Information

Published In

Go to American Journal of Psychiatry
Go to American Journal of Psychiatry
American Journal of Psychiatry
Volume 177 • Number 12 • December 01, 2020
Pages: 1180 - 1181
PubMed: 33256452

History

Accepted: 15 June 2020
Published online: 1 December 2020
Published in print: December 01, 2020

Keywords

  1. Psychosis
  2. Early Intervention
  3. Duration of Untreated Psychosis
  4. Epidemiology
  5. Treatment Delay
  6. First-Episode Psychosis

Authors

Affiliations

Srividya N. Iyer, Ph.D. [email protected]
Department of Psychiatry and Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada (Iyer, Malla, Shah); Prevention and Early Intervention Program for Psychosis, Douglas Mental Health University Institute, Montreal, Canada (Iyer, Malla, Shah); Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (Anderson, Norman).
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Kelly K. Anderson, Ph.D.
Department of Psychiatry and Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada (Iyer, Malla, Shah); Prevention and Early Intervention Program for Psychosis, Douglas Mental Health University Institute, Montreal, Canada (Iyer, Malla, Shah); Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (Anderson, Norman).
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Ashok Malla, M.B.B.S., F.R.C.P.(C.)
Department of Psychiatry and Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada (Iyer, Malla, Shah); Prevention and Early Intervention Program for Psychosis, Douglas Mental Health University Institute, Montreal, Canada (Iyer, Malla, Shah); Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (Anderson, Norman).
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Jai Shah, M.D., F.R.C.P.(C.)
Department of Psychiatry and Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada (Iyer, Malla, Shah); Prevention and Early Intervention Program for Psychosis, Douglas Mental Health University Institute, Montreal, Canada (Iyer, Malla, Shah); Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (Anderson, Norman).
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Ross Norman, Ph.D.
Department of Psychiatry and Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada (Iyer, Malla, Shah); Prevention and Early Intervention Program for Psychosis, Douglas Mental Health University Institute, Montreal, Canada (Iyer, Malla, Shah); Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (Anderson, Norman).
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Notes

Send correspondence to Dr. Iyer ([email protected]).

Funding Information

Dr. Iyer is supported by a salary award from the Canadian Institutes of Health Research. Dr. Shah is supported by a clinician-scientist award from the Fonds de recherche du Québec–Santé.Dr. Malla has received honoraria for plenary lectures and presentations in symposia sponsored by Lundbeck and Otsuka and has received consultation fees for providing research consultation on a Canadian study. The other authors report no financial relationships with commercial interests.

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