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American Journal of Psychiatry

  • Volume 177
  • Number 12
  • December 2020
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Editor’s Note

Molecules and Circuits Implicated in Schizophrenia Provide Leads for Novel Treatments

Publication date: 01 December 2020

Pages1099–1102https://doi.org/10.1176/appi.ajp.2020.20101475
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Editorials

The Evolutionary Expansion of mGluR3-NAAG-GCPII Signaling: Relevance to Human Intelligence and Cognitive Disorders

Publication date: 01 December 2020

Pages1103–1106https://doi.org/10.1176/appi.ajp.2020.20101458
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Cell-Type-Specific Transcriptomic Analysis in the Dorsolateral Prefrontal Cortex Reveals Distinct Mitochondrial Abnormalities in Schizophrenia and Bipolar Disorder

Publication date: 01 December 2020

Pages1107–1109https://doi.org/10.1176/appi.ajp.2020.20101455
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Bayesian Dysconnections

Publication date: 01 December 2020

Pages1110–1112https://doi.org/10.1176/appi.ajp.2020.20091421
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How Much of an Advance Is the Addition of Samidorphan to Olanzapine?

Publication date: 01 December 2020

Pages1113–1114https://doi.org/10.1176/appi.ajp.2020.20091425
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Commentaries

Involuntary Commitments: Billing Patients for Forced Psychiatric Care

Publication date: 01 December 2020

Pages1115–1116https://doi.org/10.1176/appi.ajp.2020.20030319
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Essential Work: Psychiatric Clinical Investigation in the Midst of a Pandemic

Publication date: 01 December 2020

Pages1117–1118https://doi.org/10.1176/appi.ajp.2020.20050722
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Reviews and Overviews

Fifty Years of Research on Schizophrenia: The Ascendance of the Glutamatergic Synapse

Publication date: 01 December 2020

Pages1119–1128https://doi.org/10.1176/appi.ajp.2020.20101481
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Articles

Video

Association of Missense Mutation in FOLH1 With Decreased NAAG Levels and Impaired Working Memory Circuitry and Cognition

Publication date: 01 December 2020

Pages1129–1139

Objective: Altering the metabotropic glutamate receptor 3 (mGluR3) by pharmacology or genetics is associated with differences in learning and memory in animals and humans. GRM3 (the gene coding for mGluR3) is also genome-wide associated with risk for ...

https://doi.org/10.1176/appi.ajp.2020.19111152
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Diagnosis- and Cell Type-Specific Mitochondrial Functional Pathway Signatures in Schizophrenia and Bipolar Disorder

Publication date: 29 October 2020

Pages1140–1150

Objective: The shared risk factors and clinical features in schizophrenia and bipolar disorder may be linked via mitochondrial dysfunction. However, the severity of mitochondrial dysfunction, and/or the specific mitochondrial functional pathways affected, ...

https://doi.org/10.1176/appi.ajp.2020.19111210
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Video

Parietal-Prefrontal Feedforward Connectivity in Association With Schizophrenia Genetic Risk and Delusions

Publication date: 27 May 2020

Pages1151–1158

Objective: Conceptualizations of delusion formation implicate deficits in feedforward information updating across the posterior to prefrontal cortices, resulting in dysfunctional integration of new information about contexts in working memory and, ...

https://doi.org/10.1176/appi.ajp.2020.19111176
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Video

Thalamic Nuclei Volumes in Psychotic Disorders and in Youths With Psychosis Spectrum Symptoms

Publication date: 11 September 2020

Pages1159–1167

Objective: Thalamus models of psychosis implicate association nuclei in the pathogenesis of psychosis and mechanisms of cognitive impairment. Studies to date have provided conflicting findings for structural deficits specific to these nuclei. The authors ...

https://doi.org/10.1176/appi.ajp.2020.19101099
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Effects of Olanzapine Combined With Samidorphan on Weight Gain in Schizophrenia: A 24-Week Phase 3 Study

Publication date: 14 August 2020

Pages1168–1178

Objective: A combination of olanzapine and the opioid receptor antagonist samidorphan is under development for the treatment of schizophrenia and bipolar I disorder. The single-tablet combination treatment is intended to provide the efficacy of olanzapine ...

https://doi.org/10.1176/appi.ajp.2020.19121279
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Letters to the Editor

Are All Psychotic-Like Experiences Really “Psychotic”?

Publication date: 01 December 2020

Page1179https://doi.org/10.1176/appi.ajp.2020.20040485
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Are All Psychotic-Like Experiences Really “Psychotic”?: Response to McLawhorn and Jackson

Publication date: 01 December 2020

Pages1179–1180https://doi.org/10.1176/appi.ajp.2020.20040485r
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The Case for Cautious Interpretation and Replication: Lead-Time Bias as a Potential Explanation for the Link Between Duration of Untreated Psychosis and Outcome

Publication date: 01 December 2020

Pages1180–1181https://doi.org/10.1176/appi.ajp.2020.20030299
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Lead-Time Bias as a Potential Explanation for the Link Between Duration of Untreated Psychosis and Outcome: Response to Iyer et al.

Publication date: 01 December 2020

Pages1181–1183https://doi.org/10.1176/appi.ajp.2020.20030299r
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Duration of Untreated Psychosis: Getting Both the Timing and the Sample Right

Publication date: 01 December 2020

Page1183https://doi.org/10.1176/appi.ajp.2020.20040389
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Duration of Untreated Psychosis: Getting Both the Timing and the Sample Right: Response to Woods et al.

Publication date: 01 December 2020

Pages1183–1185https://doi.org/10.1176/appi.ajp.2020.20040389r
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Natural History, Not Lead Time

Publication date: 01 December 2020

Page1185https://doi.org/10.1176/appi.ajp.2020.20040402
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Natural History, Not Lead Time: Response to Srihari et al.

Publication date: 01 December 2020

Pages1185–1186https://doi.org/10.1176/appi.ajp.2020.20040402r
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Appreciation

Reviewers for The American Journal of Psychiatry

Publication date: 01 December 2020

Pages1187–1190https://doi.org/10.1176/appi.ajp.2020.17712reviewers
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