American Journal of Psychiatry

Obsessive-compulsive disorder (OCD) is a common, chronic, and oftentimes disabling disorder. The only established first-line treatments for OCD are exposure and response prevention, and serotonin reuptake inhibitor medications (SRIs). However, a subset of ...

https://doi.org/10.1176/appi.ajp.2020.20111601

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Autism Spectrum Disorder Genetics and the Search for Pathological Mechanisms

Publication date: 01 January 2021

Pages30–38

Recent progress in the identification of genes and genomic regions contributing to autism spectrum disorder (ASD) has had a broad impact on our understanding of the nature of genetic risk for a range of psychiatric disorders, on our understanding of ASD ...

https://doi.org/10.1176/appi.ajp.2020.20111608

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Treatment-Specific Associations Between Brain Activation and Symptom Reduction in OCD Following CBT: A Randomized fMRI Trial

Publication date: 28 August 2020

Pages39–47

Objective:The authors sought to examine whether brain activity is associated with treatment response to cognitive-behavioral therapy (CBT) in adolescents and adults with obsessive-compulsive disorder (OCD), and whether any associations are treatment ...

https://doi.org/10.1176/appi.ajp.2020.19080886

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Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity

Publication date: 16 June 2020

Pages48–64

Objective:Pediatric obsessive-compulsive disorder (OCD) sometimes appears rapidly, even overnight, often after an infection. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections, or PANDAS, describes such a situation ...

https://doi.org/10.1176/appi.ajp.2020.19070698

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Diagnostic Classification for Human Autism and Obsessive-Compulsive Disorder Based on Machine Learning From a Primate Genetic Model

Publication date: 16 June 2020

Pages65–76

Objective:Psychiatric disorders commonly comprise comorbid symptoms, such as autism spectrum disorder (ASD), obsessive-compulsive disorder (OCD), and attention deficit hyperactivity disorder (ADHD), raising controversies over accurate diagnosis and ...

https://doi.org/10.1176/appi.ajp.2020.19101091

A Genetics-First Approach to Dissecting the Heterogeneity of Autism: Phenotypic Comparison of Autism Risk Copy Number Variants

Publication date: 01 January 2021

Pages77–86

Objective:Certain copy number variants (CNVs) greatly increase the risk of autism. The authors conducted a genetics-first study to investigate whether heterogeneity in the clinical presentation of autism is underpinned by specific genotype-phenotype ...

https://doi.org/10.1176/appi.ajp.2020.20010015

Effect Sizes of Deletions and Duplications on Autism Risk Across the Genome

Publication date: 11 September 2020

Pages87–98

Objective:Deleterious copy number variants (CNVs) are identified in up to 20% of individuals with autism. However, levels of autism risk conferred by most rare CNVs remain unknown. The authors recently developed statistical models to estimate the effect ...

https://doi.org/10.1176/appi.ajp.2020.19080834