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Published Online: 3 March 2022

Putting Genetics to Work in the Psychiatric Clinic

Abstract

The rapid progress in psychiatric genetics over the past 10 years, while exciting from a research perspective, has not yet had an impact on clinical practice. How will we really be able to put genetics to work in the psychiatric clinic? This overview will attempt to answer this question. A survey of widely used methods and major study designs highlights key findings that have emerged so far. These findings inform a broad conceptual model of how genetic risk may act to influence dimensions of psychopathology and clinical presentations. The overview concludes with highlights of some of the most clinically relevant findings to date and their implications for psychiatric practice in the near future.

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Information

Published In

Go to American Journal of Psychiatry
Go to American Journal of Psychiatry
American Journal of Psychiatry
Pages: 182 - 188
PubMed: 35236113

History

Received: 10 January 2022
Accepted: 11 January 2022
Published in print: March 2022
Published online: 3 March 2022

Keywords

  1. Genetics/Genomics
  2. Translational Research

Authors

Details

Francis J. McMahon, M.D. [email protected]
Human Genetics Branch, NIMH Intramural Research Program, Bethesda, Md.

Notes

Send correspondence to Dr. McMahon ([email protected]).

Competing Interests

The author reports no financial relationships with commercial interests.

Funding Information

Supported in part by the NIMH Intramural Research Program (grant ZIA-MH002843).

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