American Journal of Psychiatry
- Volume 179
- Number 3
- March 2022
Editor's Note
Editorials
Reviews and Overviews
Publication date: 01 March 2022
Pages182–188The rapid progress in psychiatric genetics over the past 10 years, while exciting from a research perspective, has not yet had an impact on clinical practice. How will we really be able to put genetics to work in the psychiatric clinic? This overview will ...
https://doi.org/10.1176/appi.ajp.2021.22010024Publication date: 01 March 2022
Pages189–203Rare genomic disorders (RGDs) confer elevated risk for neurodevelopmental psychiatric disorders. In this era of intense genomics discoveries, the landscape of RGDs is rapidly evolving. However, there has not been comparable progress to date in scalable, ...
https://doi.org/10.1176/appi.ajp.2021.21040432Articles
Publication date: 01 March 2022
Pages204–215Objective: Brain oscillations play a pivotal role in synchronizing responses of local and global ensembles of neurons. Patients with schizophrenia exhibit impairments in oscillatory response, which are thought to stem from abnormal maturation during ...
https://doi.org/10.1176/appi.ajp.2021.21020190Publication date: 18 November 2021
Pages216–225Objective: Obsessive-compulsive disorder (OCD) is known to be substantially heritable; however, the contribution of genetic variation across the allele frequency spectrum to this heritability remains uncertain. The authors used two new homogeneous cohorts ...
https://doi.org/10.1176/appi.ajp.2021.21010101Publication date: 01 March 2022
Pages226–241Objective: The authors sought to study the transcriptomic and genomic features of completed suicide by parsing the method chosen, to capture molecular correlates of the distinctive frame of mind of individuals who die by suicide, while reducing ...
https://doi.org/10.1176/appi.ajp.2021.21030299Publication date: 10 September 2021
Pages242–254Objective: Autism spectrum disorder (ASD) is accompanied by highly individualized neuroanatomical deviations that potentially map onto distinct genotypes and clinical phenotypes. This study aimed to link differences in brain anatomy to specific biological ...
https://doi.org/10.1176/appi.ajp.2021.20050630