The major cause of disability in schizophrenia is cognitive impairment, which remains largely refractory to existing treatments. This reflects the fact that antipsychotics and other therapies have not been designed to address specific brain abnormalities ...

https://doi.org/10.1176/appi.ajp.20220147

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Synaptic Variability and Cortical Gamma Oscillation Power in Schizophrenia

Publication date: 01 April 2022

Pages277–287

Objective:Cognitive impairments in schizophrenia are associated with lower gamma oscillation power in the prefrontal cortex (PFC). Gamma power depends in part on excitatory drive to fast-spiking parvalbumin interneurons (PVIs). Excitatory drive to ...

https://doi.org/10.1176/appi.ajp.2021.21080798

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20-Year Prospective, Sequential Follow-Up Study of Heterogeneity in Associations of Duration of Untreated Psychosis With Symptoms, Functioning, and Quality of Life Following First-Episode Psychosis

Publication date: 01 April 2022

Pages288–297

Objective:Determining the extent to which relationships between duration of untreated psychosis (DUP) and outcome endure longitudinally across the lifetime course of psychotic illness requires prospective, systematic studies of epidemiologically ...

https://doi.org/10.1176/appi.ajp.2021.20111658

Association of Medication Treatment for Opioid Use Disorder With Suicide Mortality

Publication date: 01 April 2022

Pages298–304

Objective:Understanding the effectiveness of medication treatment for opioid use disorder to decrease the risk of suicide mortality may inform clinical and policy decisions. The authors sought to describe the effect of medications for opioid use disorder (...

https://doi.org/10.1176/appi.ajp.2021.21070700

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Effects of County-Level Opioid Dispensing Rates on Individual-Level Patterns of Prescription Opioid and Heroin Consumption: Evidence From National U.S. Data

Publication date: 08 December 2021

Pages305–311

Objective:The authors examined directly whether county-level changes in opioid dispensing rates affect individual-level prescription opioid misuse, frequency of use, and dependence, as well as the same outcomes for heroin.Methods:Using data from the ...

https://doi.org/10.1176/appi.ajp.2021.21060602