Interindividual Differences in Cortical Thickness and Their Genomic Underpinnings in Autism Spectrum Disorder
Abstract
Objective:
Methods:
Results:
Conclusions:
Methods
Participants
Variable | Typically Developing Group (N=279) | ASD Group (N=360) | Analysis | ||||
---|---|---|---|---|---|---|---|
N | % | N | % | χ2 | df | p | |
Sex | 4.45 | 1 | <0.03 | ||||
Male | 178 | 63.8 | 259 | 71.9 | |||
Female | 101 | 36.2 | 101 | 28.1 | |||
Mean | SD | Mean | SD | t | p | ||
Age (years) | 17.33 | 5.91 | 17.51 | 5.51 | –0.40 | 576 | 0.69 |
Full-scale IQ | 104.79 | 18.25 | 98.86 | 19.72 | 3.93 | 617 | <0.01 |
ADI-R scores | |||||||
Social interaction | 16.68 | 6.69 | |||||
Communication | 13.22 | 5.63 | |||||
Restricted and repetitive behaviors | 4.29 | 2.67 | |||||
ADOS scores | |||||||
Total | 6.07 | 2.64 | |||||
Social affect | 6.77 | 2.40 | |||||
Restricted and repetitive behaviors | 4.70 | 2.62 | |||||
Total brain volume (liters) | 1.19 | 0.13 | 1.19 | 0.13 | –0.15 | 603 | 0.88 |
Mean cortical thickness (mm) | 2.67 | 0.11 | 2.68 | 0.13 | –0.78 | 623 | 0.43 |
MRI Data Acquisition
Cortical Surface Reconstructions Using FreeSurfer
Surface-Based Statistical Analyses of Cortical Thickness
Genetic Analyses
Neuroanatomical Differences and Genetic Underpinnings of Clinical ASD Subgroups
Results
Vertex-Wise Between-Group Differences in Cortical Thickness
Vertex-Level Deviations From the Neurotypical Distribution of Cortical Thickness
Gene Expression Decoding and Enrichment Analyses
Correlations Between tAIs and Polygenic Score for ASD
Differences in Neuroanatomical Deviations Across Different Sensory Subgroups
Discussion
Supplementary Material
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