Skip to main content

Abstract

This review of emerging data linking inflammatory processes to the pathophysiology and treatment of njor depressive disorder exemplifies how the field is moving forward from historically bound, monoamine-based hypotheses.

Abstract

This article will review the evidence for the “inflammatory hypothesis of depression.” The authors summarize the literature suggesting that immune-mediated changes contribute to the pathophysiology of MDD; describe potential underlying mechanisms; and discuss translational targets, including proinflammatory cytokines and cytokine-signaling pathways, for the development of novel antidepressants.

Formats available

You can view the full content in the following formats:

Information & Authors

Information

Published In

History

Published online: 1 October 2012
Published in print: Fall 2012

Authors

Affiliations

Notes

Address correspondence to Dr. Soskin, Depression Clinical and Research Program, Massachusetts General Hospital, One Bowdoin Square – 6th Floor, Boston, MA, 02114; e-mail: [email protected]

Funding Information

Author Information and CME Disclosure

Metrics & Citations

Metrics

Citations

Export Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.

For more information or tips please see 'Downloading to a citation manager' in the Help menu.

Format
Citation style
Style
Copy to clipboard

There are no citations for this item

View Options

View options

PDF/ePub

View PDF/ePub

Full Text

View Full Text

Get Access

Login options

Already a subscriber? Access your subscription through your login credentials or your institution for full access to this article.

Personal login Institutional Login Open Athens login
Purchase Options

Purchase this article to access the full text.

PPV Articles - Focus

PPV Articles - Focus

Not a subscriber?

Subscribe Now / Learn More

PsychiatryOnline subscription options offer access to the DSM-5-TR® library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

Media

Figures

Other

Tables

Share

Share

Share article link

Share