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Abstract

This review of emerging data linking inflammatory processes to the pathophysiology and treatment of njor depressive disorder exemplifies how the field is moving forward from historically bound, monoamine-based hypotheses.

Abstract

This article will review the evidence for the “inflammatory hypothesis of depression.” The authors summarize the literature suggesting that immune-mediated changes contribute to the pathophysiology of MDD; describe potential underlying mechanisms; and discuss translational targets, including proinflammatory cytokines and cytokine-signaling pathways, for the development of novel antidepressants.

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Published online: 1 October 2012
Published in print: Fall 2012

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Address correspondence to Dr. Soskin, Depression Clinical and Research Program, Massachusetts General Hospital, One Bowdoin Square – 6th Floor, Boston, MA, 02114; e-mail: [email protected]

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