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Published Online: 1 July 2014

Cognitive Function in Patients With Alcoholic and Nonalcoholic Chronic Liver Disease

Carlos Brodersen, M.D., Eduardo Koen, M.D., Alicia Ponte, M.D., Silvina Sánchez, M.D., Eduardo Segal, M.D., Alberto Chiapella, M.D., Maria Fernández, Maria Torres, M.D., Valeria Tripodi, Dr. in Biochemistry, and Abraham Lemberg, M.D.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 26, Number 3
https://doi.org/10.1176/appi.neuropsych.12040091
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Abstract

The aim of the present study was to characterize the neurophysiological profile of cognitive impairment associated with patients with chronic alcoholic and nonalcoholic liver disease. The authors evaluated 43 patients with cirrhotic liver disease: 19 patients with chronic alcohol ingestion and 24 nonalcoholic patients who had been infected with hepatitis B or C virus. Eleven healthy subjects were included as control subjects. A battery of 12 psychological tests was used to investigate cognitive deficits in the patients with chronic liver disease. It was observed that alcoholic patients with chronic liver disease showed a more important cognitive deterioration than those affected by hepatitis B or C virus.

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Information & Authors

Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 26 • Number 3 • Summer 2014
Pages: 241 - 248
PubMed: 25093764

History

Received: 13 April 2012
Revision received: 25 March 2013
Revision received: 8 April 2013
Revision received: 2 May 2013
Accepted: 3 May 2013
Published online: 1 July 2014
Published in print: Summer 2014

Authors

Affiliations

Carlos Brodersen, M.D.
From the Gastroenterology Division, Hospital Durand, Buenos Aires, Argentina (CB); the Psychology Service, Hospital Durand, Buenos Aires, Argentina (EK, AP, E Sánchez, E Segal, AC); the Dept. of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina (MF, MT, AL); the Dept. of Analytical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina (VT); and the Consejo Nacional de Investigaciones Científicas y Tecnológicas, CONICET, Buenos Aires, Argentina (VT).
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Eduardo Koen, M.D.
From the Gastroenterology Division, Hospital Durand, Buenos Aires, Argentina (CB); the Psychology Service, Hospital Durand, Buenos Aires, Argentina (EK, AP, E Sánchez, E Segal, AC); the Dept. of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina (MF, MT, AL); the Dept. of Analytical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina (VT); and the Consejo Nacional de Investigaciones Científicas y Tecnológicas, CONICET, Buenos Aires, Argentina (VT).
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Alicia Ponte, M.D.
From the Gastroenterology Division, Hospital Durand, Buenos Aires, Argentina (CB); the Psychology Service, Hospital Durand, Buenos Aires, Argentina (EK, AP, E Sánchez, E Segal, AC); the Dept. of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina (MF, MT, AL); the Dept. of Analytical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina (VT); and the Consejo Nacional de Investigaciones Científicas y Tecnológicas, CONICET, Buenos Aires, Argentina (VT).
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Silvina Sánchez, M.D.
From the Gastroenterology Division, Hospital Durand, Buenos Aires, Argentina (CB); the Psychology Service, Hospital Durand, Buenos Aires, Argentina (EK, AP, E Sánchez, E Segal, AC); the Dept. of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina (MF, MT, AL); the Dept. of Analytical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina (VT); and the Consejo Nacional de Investigaciones Científicas y Tecnológicas, CONICET, Buenos Aires, Argentina (VT).
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Eduardo Segal, M.D.
From the Gastroenterology Division, Hospital Durand, Buenos Aires, Argentina (CB); the Psychology Service, Hospital Durand, Buenos Aires, Argentina (EK, AP, E Sánchez, E Segal, AC); the Dept. of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina (MF, MT, AL); the Dept. of Analytical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina (VT); and the Consejo Nacional de Investigaciones Científicas y Tecnológicas, CONICET, Buenos Aires, Argentina (VT).
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Alberto Chiapella, M.D.
From the Gastroenterology Division, Hospital Durand, Buenos Aires, Argentina (CB); the Psychology Service, Hospital Durand, Buenos Aires, Argentina (EK, AP, E Sánchez, E Segal, AC); the Dept. of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina (MF, MT, AL); the Dept. of Analytical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina (VT); and the Consejo Nacional de Investigaciones Científicas y Tecnológicas, CONICET, Buenos Aires, Argentina (VT).
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Maria Fernández
From the Gastroenterology Division, Hospital Durand, Buenos Aires, Argentina (CB); the Psychology Service, Hospital Durand, Buenos Aires, Argentina (EK, AP, E Sánchez, E Segal, AC); the Dept. of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina (MF, MT, AL); the Dept. of Analytical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina (VT); and the Consejo Nacional de Investigaciones Científicas y Tecnológicas, CONICET, Buenos Aires, Argentina (VT).
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Maria Torres, M.D.
From the Gastroenterology Division, Hospital Durand, Buenos Aires, Argentina (CB); the Psychology Service, Hospital Durand, Buenos Aires, Argentina (EK, AP, E Sánchez, E Segal, AC); the Dept. of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina (MF, MT, AL); the Dept. of Analytical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina (VT); and the Consejo Nacional de Investigaciones Científicas y Tecnológicas, CONICET, Buenos Aires, Argentina (VT).
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Valeria Tripodi, Dr. in Biochemistry
From the Gastroenterology Division, Hospital Durand, Buenos Aires, Argentina (CB); the Psychology Service, Hospital Durand, Buenos Aires, Argentina (EK, AP, E Sánchez, E Segal, AC); the Dept. of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina (MF, MT, AL); the Dept. of Analytical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina (VT); and the Consejo Nacional de Investigaciones Científicas y Tecnológicas, CONICET, Buenos Aires, Argentina (VT).
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Abraham Lemberg, M.D.
From the Gastroenterology Division, Hospital Durand, Buenos Aires, Argentina (CB); the Psychology Service, Hospital Durand, Buenos Aires, Argentina (EK, AP, E Sánchez, E Segal, AC); the Dept. of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina (MF, MT, AL); the Dept. of Analytical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina (VT); and the Consejo Nacional de Investigaciones Científicas y Tecnológicas, CONICET, Buenos Aires, Argentina (VT).
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Notes

Send correspondence to Abraham Lemberg, M.D.; e-mail: [email protected]

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