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Published Online: 1 October 2013

Hippocampal Volume Reduction Correlates With Apathy in Traumatic Brain Injury, But Not Schizophrenia

Publication: The Journal of Neuropsychiatry and Clinical Neurosciences

Abstract

Imaging findings revealed specific areas of volume reduction in TBI survivors and areas of cortical thinning among patients with deficit syndrome schizophrenia. The severity of apathy symptoms was similar across patient groups; however, severity of apathy was only correlated with imaging findings in TBI survivors.

Abstract

Apathy commonly accompanies both traumatic brain injury (TBI) and deficit syndrome schizophrenia (DSZ), despite unclear neurological bases. The authors examined differences in cortical thickness and subcortical/cerebellar regional volumes between adult TBI survivors, patients with DSZ, and healthy-control subjects by use of 3-D magnetic resonance imaging (MRI), and correlated imaging findings with clinical ratings of apathy and selected cognitive test scores. Imaging findings revealed specific areas of volume reduction in TBI survivors and areas of cortical thinning among patients with DSZ. The severity of apathy symptoms was similar across patient groups; however, severity of apathy was only correlated with imaging findings in TBI survivors.

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Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Pages: 292 - 301
PubMed: 24247856

History

Received: 14 April 2012
Revision received: 1 September 2012
Revision received: 5 December 2012
Accepted: 6 December 2012
Published online: 1 October 2013
Published in print: Fall 2013

Authors

Details

Yoichiro Takayanagi, M.D., Ph.D.
From the Dept. of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, and the Dept. of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
Gwendoly Gerner, Psy.D.
From the Dept. of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, and the Dept. of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
Mizuho Takayanagi, M.D.
From the Dept. of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, and the Dept. of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
Vani Rao, M.D.
From the Dept. of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, and the Dept. of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
Tracy D. Vannorsdall, Ph.D.
From the Dept. of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, and the Dept. of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
Akira Sawa, M.D., Ph.D.
From the Dept. of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, and the Dept. of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
David J. Schretlen, Ph.D.
From the Dept. of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, and the Dept. of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
Nicola G. Cascella, M.D.
From the Dept. of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, and the Dept. of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.

Notes

Send correspondence to Dr. Cascella; e-mail: [email protected] or Dr. Schretlen; e-mail: [email protected]

Funding Information

This study was supported by a NARSAD Young Investigator Award (to Dr. Cascella) and NIH grants R01 MH060504 and R01 MH077852 (to Dr. Schretlen); P50 MH094268 (to Dr. Sawa); R01 MH078175 and R33 MH079017 (to Dr. Cascella); and a grant from the Stanley Foundation (to Dr. Cascella).

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