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Published Online: 1 October 2013

Apathy Is Associated With Increased Amyloid Burden in Mild Cognitive Impairment

Gad A. Marshall, M.D., Nancy J. Donovan, M.D., Natacha Lorius, B.A., Christopher M. Gidicsin, B.A., Jacqueline Maye, B.S., Lesley C. Pepin, B.A., J. Alex Becker, Ph.D., Rebecca E. Amariglio, Ph.D., Dorene M. Rentz, Psy.D., Reisa A. Sperling, M.D., and Keith A. Johnson, M.D.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 25, Number 4
https://doi.org/10.1176/appi.neuropsych.12060156
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Abstract

Increased apathy is associated with greater amyloid burden but not regional hypometabolism in mild cognitive impairment.

Abstract

Apathy is the most common neuropsychiatric symptom in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) dementia. The authors sought to determine whether apathy is associated with cortical amyloid burden, as measured by Pittsburgh Compound B (PiB) positron emission tomography (PET), and regional hypometabolism, measured by 18F-fluorodeoxyglocuse (FDG) PET in MCI. The authors found a significant association between increased apathy (lower Apathy Evaluation Scale score) and greater cortical PiB retention independent of age, but no significant association between apathy and regional FDG metabolism. These results suggest that increased apathy is associated with greater amyloid burden but not regional hypometabolism in MCI.

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Information & Authors

Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 25 • Number 4 • Fall 2013
Pages: 302 - 307
PubMed: 24247857

History

Received: 25 June 2012
Accepted: 2 October 2012
Published online: 1 October 2013
Published in print: Fall 2013

Authors

Details

Gad A. Marshall, M.D.
From the Center for Alzheimer Research and Treatment (GAM, NL, REA, DMR, RAS, KAJ), Dept. of Neurology (GAM, NL, REA, DMR, RAS, KAJ), and Dept. of Psychiatry (NL, REA, DMR), Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, and the Dept. of Neurology (GAM, REA, DMR, RAS) and Dept. of Radiology (KAJ), Massachusetts General Hospital, Harvard Medical School, Boston, MA.
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Nancy J. Donovan, M.D.
From the Center for Alzheimer Research and Treatment (GAM, NL, REA, DMR, RAS, KAJ), Dept. of Neurology (GAM, NL, REA, DMR, RAS, KAJ), and Dept. of Psychiatry (NL, REA, DMR), Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, and the Dept. of Neurology (GAM, REA, DMR, RAS) and Dept. of Radiology (KAJ), Massachusetts General Hospital, Harvard Medical School, Boston, MA.
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Natacha Lorius, B.A.
From the Center for Alzheimer Research and Treatment (GAM, NL, REA, DMR, RAS, KAJ), Dept. of Neurology (GAM, NL, REA, DMR, RAS, KAJ), and Dept. of Psychiatry (NL, REA, DMR), Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, and the Dept. of Neurology (GAM, REA, DMR, RAS) and Dept. of Radiology (KAJ), Massachusetts General Hospital, Harvard Medical School, Boston, MA.
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Christopher M. Gidicsin, B.A.
From the Center for Alzheimer Research and Treatment (GAM, NL, REA, DMR, RAS, KAJ), Dept. of Neurology (GAM, NL, REA, DMR, RAS, KAJ), and Dept. of Psychiatry (NL, REA, DMR), Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, and the Dept. of Neurology (GAM, REA, DMR, RAS) and Dept. of Radiology (KAJ), Massachusetts General Hospital, Harvard Medical School, Boston, MA.
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Jacqueline Maye, B.S.
From the Center for Alzheimer Research and Treatment (GAM, NL, REA, DMR, RAS, KAJ), Dept. of Neurology (GAM, NL, REA, DMR, RAS, KAJ), and Dept. of Psychiatry (NL, REA, DMR), Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, and the Dept. of Neurology (GAM, REA, DMR, RAS) and Dept. of Radiology (KAJ), Massachusetts General Hospital, Harvard Medical School, Boston, MA.
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Lesley C. Pepin, B.A.
From the Center for Alzheimer Research and Treatment (GAM, NL, REA, DMR, RAS, KAJ), Dept. of Neurology (GAM, NL, REA, DMR, RAS, KAJ), and Dept. of Psychiatry (NL, REA, DMR), Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, and the Dept. of Neurology (GAM, REA, DMR, RAS) and Dept. of Radiology (KAJ), Massachusetts General Hospital, Harvard Medical School, Boston, MA.
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J. Alex Becker, Ph.D.
From the Center for Alzheimer Research and Treatment (GAM, NL, REA, DMR, RAS, KAJ), Dept. of Neurology (GAM, NL, REA, DMR, RAS, KAJ), and Dept. of Psychiatry (NL, REA, DMR), Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, and the Dept. of Neurology (GAM, REA, DMR, RAS) and Dept. of Radiology (KAJ), Massachusetts General Hospital, Harvard Medical School, Boston, MA.
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Rebecca E. Amariglio, Ph.D.
From the Center for Alzheimer Research and Treatment (GAM, NL, REA, DMR, RAS, KAJ), Dept. of Neurology (GAM, NL, REA, DMR, RAS, KAJ), and Dept. of Psychiatry (NL, REA, DMR), Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, and the Dept. of Neurology (GAM, REA, DMR, RAS) and Dept. of Radiology (KAJ), Massachusetts General Hospital, Harvard Medical School, Boston, MA.
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Dorene M. Rentz, Psy.D.
From the Center for Alzheimer Research and Treatment (GAM, NL, REA, DMR, RAS, KAJ), Dept. of Neurology (GAM, NL, REA, DMR, RAS, KAJ), and Dept. of Psychiatry (NL, REA, DMR), Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, and the Dept. of Neurology (GAM, REA, DMR, RAS) and Dept. of Radiology (KAJ), Massachusetts General Hospital, Harvard Medical School, Boston, MA.
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Reisa A. Sperling, M.D.
From the Center for Alzheimer Research and Treatment (GAM, NL, REA, DMR, RAS, KAJ), Dept. of Neurology (GAM, NL, REA, DMR, RAS, KAJ), and Dept. of Psychiatry (NL, REA, DMR), Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, and the Dept. of Neurology (GAM, REA, DMR, RAS) and Dept. of Radiology (KAJ), Massachusetts General Hospital, Harvard Medical School, Boston, MA.
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Keith A. Johnson, M.D.
From the Center for Alzheimer Research and Treatment (GAM, NL, REA, DMR, RAS, KAJ), Dept. of Neurology (GAM, NL, REA, DMR, RAS, KAJ), and Dept. of Psychiatry (NL, REA, DMR), Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, and the Dept. of Neurology (GAM, REA, DMR, RAS) and Dept. of Radiology (KAJ), Massachusetts General Hospital, Harvard Medical School, Boston, MA.
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Notes

Send correspondence to Gad A. Marshall, M.D.; e-mail: [email protected]

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