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Published Online: 1 July 2014

Marked Reduction in Serotonergic Activity in a Sexually Aggressive Adolescent Male

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Adarsh M. Kumar, Ph.D., Mahendra Kumar, Ph.D., Benjamin B. Lahey, Ph.D., Debra A. Katz, M.D., Benny Fernandez, M.S., Jon A. Shaw, M.D., Ana Campo, M.D., and Charles B. Nemeroff, M.D., Ph.D.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 26, Number 3
https://doi.org/10.1176/appi.neuropsych.13060138
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Abstract

Serotonergic dysfunctions are implicated in conduct disorder, impulsivity, and aggression. Early adverse experiences increase the risk for these behaviors in adolescents. The authors investigated serotonergic activity in one adolescent male who experienced maternal abandonment and childhood abuse and exhibited severely aggressive sexual offenses. Platelet serotonin (5-HT) concentration, [14C]-5HT uptake kinetics, and plasma prolactin, cortisol response to D,L-fenfluramine (D,L-FEN) were measured. Results showed extremely low 5-HT concentration (2.960.7 ng/108 platelets), [14C]-5HT uptake rate (0.560.04 mM/min/107platelets), undetectable Km and Vmax, and abnormally blunted prolactin, cortisol response to D,L-FEN. These abnormalities in this sexually aggressive adolescent may be a consequence of childhood abuse.

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Information & Authors

Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 26 • Number 3 • Summer 2014
Pages: 262 - 270
PubMed: 25093765

History

Received: 21 June 2013
Revision received: 17 September 2013
Accepted: 18 September 2013
Published online: 1 July 2014
Published in print: Summer 2014

Authors

Details

Adarsh M. Kumar, Ph.D.
From the Dept. of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine Miami, FL (AMK, MK, BF, JAS, AC, CBN); Dept. of Psychiatry, University of Kentucky College of Medicine, Lexington, KY (DAK); and Dept. of Psychiatry, University of Chicago, Chicago, IL (BBL).
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Mahendra Kumar, Ph.D.
From the Dept. of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine Miami, FL (AMK, MK, BF, JAS, AC, CBN); Dept. of Psychiatry, University of Kentucky College of Medicine, Lexington, KY (DAK); and Dept. of Psychiatry, University of Chicago, Chicago, IL (BBL).
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Benjamin B. Lahey, Ph.D.
From the Dept. of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine Miami, FL (AMK, MK, BF, JAS, AC, CBN); Dept. of Psychiatry, University of Kentucky College of Medicine, Lexington, KY (DAK); and Dept. of Psychiatry, University of Chicago, Chicago, IL (BBL).
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Debra A. Katz, M.D.
From the Dept. of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine Miami, FL (AMK, MK, BF, JAS, AC, CBN); Dept. of Psychiatry, University of Kentucky College of Medicine, Lexington, KY (DAK); and Dept. of Psychiatry, University of Chicago, Chicago, IL (BBL).
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Benny Fernandez, M.S.
From the Dept. of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine Miami, FL (AMK, MK, BF, JAS, AC, CBN); Dept. of Psychiatry, University of Kentucky College of Medicine, Lexington, KY (DAK); and Dept. of Psychiatry, University of Chicago, Chicago, IL (BBL).
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Jon A. Shaw, M.D.
From the Dept. of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine Miami, FL (AMK, MK, BF, JAS, AC, CBN); Dept. of Psychiatry, University of Kentucky College of Medicine, Lexington, KY (DAK); and Dept. of Psychiatry, University of Chicago, Chicago, IL (BBL).
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Ana Campo, M.D.
From the Dept. of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine Miami, FL (AMK, MK, BF, JAS, AC, CBN); Dept. of Psychiatry, University of Kentucky College of Medicine, Lexington, KY (DAK); and Dept. of Psychiatry, University of Chicago, Chicago, IL (BBL).
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Charles B. Nemeroff, M.D., Ph.D.
From the Dept. of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine Miami, FL (AMK, MK, BF, JAS, AC, CBN); Dept. of Psychiatry, University of Kentucky College of Medicine, Lexington, KY (DAK); and Dept. of Psychiatry, University of Chicago, Chicago, IL (BBL).
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Notes

Send correspondence to Dr. Kumar; e-mail: [email protected]

Funding Information

Dr. Charles Nemeroff has received Research/Grants from the National Institutes of Health (NIH), Agency for Healthcare Research and Quality (AHRQ); Speakers Bureau: None; is Consultant to Xhale, Takeda, SK Pharma, Taisho, Lundbeck, Shire, Roche, Lilly, Allergan, Mitsubishi Tanabe Pharma Development America; is Stockholder in, Revaax Pharma, Xhale. Has patents: Method and devices for transdermal delivery of lithium (US 6,375,990B1); Method of assessing antidepressant drug therapy via transport inhibition of monoamine neurotransmitters by ex vivo assay (US 7,148,027B2); and is on the Scientific Advisory Boards of American Foundation for Suicide Prevention (AFSP), CeNeRx BioPharma (2012), National Alliance for Research on Schizophrenia and Depression (NARSAD), Xhale, PharmaNeuroBoost (2012), Anxiety Disorders Association of America (ADAA), Skyland Trail, AstraZeneca Pharmaceuticals (2009); Board of Directors: AFSP, Mt. Cook Pharma (2010), NovaDel (2011), Skyland Trail, Gratitude America, ADAA; Income sources or equity of $10,000 or more; PharmaNeuroBoost, CeNeRx BioPharma, NovaDel Pharma, Reevax Pharma, American Psychiatric Publishing, Xhale; Various Honoraria: Various Royalties; and Expert Witness. All other authors report no financial relationships with commercial interests.

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