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Published Online: 12 June 2015

Preliminary Findings Supporting Insula Metabolic Activity as a Predictor of Outcome to Psychotherapy and Medication Treatments for Depression

Boadie W. Dunlop, M.D., M.S., Mary E. Kelley, Ph.D., Callie L. McGrath, Ph.D., W. Edward Craighead, Ph.D., and Helen S. Mayberg, M.D.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 27, Number 3
https://doi.org/10.1176/appi.neuropsych.14030048
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Abstract

A putative right anterior insula metabolism biomarker predictive of treatment outcomes was retrospectively applied to 30 depressed psychotherapy—or escitalopram-treated nonremitters who entered combination treatment. Patients whose added treatment matched the biomarker-indicated treatment remitted more often than biomarker-mismatched patients.

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Information & Authors

Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 27 • Number 3 • Summer 2015
Pages: 237 - 239
PubMed: 26067435

History

Received: 14 March 2014
Revision received: 13 May 2014
Accepted: 28 May 2014
Published online: 12 June 2015
Published in print: Summer 2015

Authors

Affiliations

Boadie W. Dunlop, M.D., M.S.
From the Dept. of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA (BWD, CLM, WEC, HSM); the Dept. of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA (MEK); and the Dept. of Psychology, Emory University, Atlanta, GA (WEC).
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Mary E. Kelley, Ph.D.
From the Dept. of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA (BWD, CLM, WEC, HSM); the Dept. of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA (MEK); and the Dept. of Psychology, Emory University, Atlanta, GA (WEC).
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Callie L. McGrath, Ph.D.
From the Dept. of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA (BWD, CLM, WEC, HSM); the Dept. of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA (MEK); and the Dept. of Psychology, Emory University, Atlanta, GA (WEC).
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W. Edward Craighead, Ph.D.
From the Dept. of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA (BWD, CLM, WEC, HSM); the Dept. of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA (MEK); and the Dept. of Psychology, Emory University, Atlanta, GA (WEC).
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Helen S. Mayberg, M.D.
From the Dept. of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA (BWD, CLM, WEC, HSM); the Dept. of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA (MEK); and the Dept. of Psychology, Emory University, Atlanta, GA (WEC).
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Notes

Send correspondence to Dr. Dunlop; E-mail: [email protected]

Funding Information

NIH Clinical Center10.13039/100000098: R01 MH073719; K23 MH086690
This work was supported by National Institutes of Health grants: R01 MH073719 (HSM), T32 GM08695 (CLM), and K23 MH086690 (BWD).The authors report no financial relationships with commercial interests.

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