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Published Online: 21 January 2016

Mood Differences Among Parkinson’s Disease Patients With Mild Cognitive Impairment

Publication: The Journal of Neuropsychiatry and Clinical Neurosciences

Abstract

Studies with healthy elderly adults suggest that apathy, depression, and anxiety are more common among individuals with mild cognitive impairment (MCI). This study examined differences in mood/amotivational symptoms among patients with Parkinson’s disease (PD) with and without MCI. Patients with PD (N=214) underwent neurocognitive evaluations including assessment of apathy (Apathy Scale), depression (Beck Depression Inventory–II), and trait anxiety (State-Trait Anxiety Inventory trait scale). Trait anxiety and depression were more severe in patients with PD with MCI. Delineation of MCI into amnestic and nonamnestic subtypes revealed greater depression, apathy, and anxiety among patients with PD with amnestic MCI relative to cognitively intact patients with PD. Patients with PD and MCI report greater mood symptoms compared to patients with PD who are cognitively intact.

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Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Pages: 211 - 216
PubMed: 26792098

History

Received: 10 September 2015
Revision received: 4 November 2015
Accepted: 21 November 2015
Published online: 21 January 2016
Published in print: Summer 2016

Authors

Affiliations

Jacob D. Jones, M.S.
From the Depts. of Clinical and Health Psychology (JDJ, PM, JL, DB) and Neurology (MSO, DB), Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, University of Florida, Gainesville.
Paul Mangal, M.S.
From the Depts. of Clinical and Health Psychology (JDJ, PM, JL, DB) and Neurology (MSO, DB), Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, University of Florida, Gainesville.
Jacob Lafo, M.S.
From the Depts. of Clinical and Health Psychology (JDJ, PM, JL, DB) and Neurology (MSO, DB), Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, University of Florida, Gainesville.
Michael S. Okun, M.D.
From the Depts. of Clinical and Health Psychology (JDJ, PM, JL, DB) and Neurology (MSO, DB), Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, University of Florida, Gainesville.
Dawn Bowers, Ph.D.
From the Depts. of Clinical and Health Psychology (JDJ, PM, JL, DB) and Neurology (MSO, DB), Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, University of Florida, Gainesville.

Notes

Send correspondence to Mr. Jones; e-mail: [email protected]

Funding Information

Mr. Mangal was supported by NIH grant T32-AG020499. Mr. Lafo was supported by NIH grant T32-NS082168. Dr. Okun was supported by NIH grants R01-NR14852 and R01-NS075012 and the Michael J. Fox Foundation. Dr. Bowers was supported by NIH grants R21-NS079767 and R03-MH109336 and SanteFe AvMed.Dr. Okun serves as a consultant for the National Parkinson Foundation. In addition, he has received research grants from NIH, the National Parkinson Foundation, the Parkinson Alliance, the Smallwood Foundation, the Bachmann-Strauss Foundation, the Tourette Syndrome Association, and the University of Florida Foundation. He has previously received honoraria but in the past 60 months has received no support from industry and has received royalties for publications with Demos, Manson, Amazon, Smashwords, Books$Patients, and Cambridge (books on movement disorders). Dr. Okun is an associate editor for NEJM Journal Watch–Neurology and has participated in continuing medical education and educational activities on movement disorders in the last 36 months sponsored by PeerView, Prime, Quantia, Henry Stewart, and Vanderbilt University. The institution, and not Dr. Okun, receives grants from Medtronic, AbbVie, and ANS/St. Jude, and the principal investigator has no financial interest in these grants. Dr. Okun has participated as a site principal investigator and/or co-investigator for several NIH-, foundation-, and industry-sponsored trials over the years but has not received honoraria. Dr. Bowers has received research support from NIH, the Michael J. Fox Foundation, the National Parkinson Foundation, and the McKnight Brain Research Foundation. All other authors report no financial relationships with commercial interests.

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