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Published Online: 8 April 2016

Cerebral Hemodynamics With rTMS in Alcohol Dependence: A Randomized, Sham-Controlled Study

Publication: The Journal of Neuropsychiatry and Clinical Neurosciences

Abstract

The authors studied cerebral hemodynamics in alcohol dependence and evaluated their changes with application of high-frequency rTMS. A prospective, single-blind, randomized, parallel-group, sham-controlled clinical study was conducted with patients with alcohol dependence (DSM-IV-TR). The study population comprised 25 subjects each in active rTMS, sham rTMS, and healthy control groups. At baseline, cerebral hemodynamic indices were measured with transcranial Doppler sonography. Subjects in the active rTMS group received 10 sessions of rTMS daily; the sham group was administered sham rTMS with the same parameters. Cerebral hemodynamic parameters were repeated 5 minutes after the last rTMS session. At baseline, mean velocity (MV) of both middle cerebral artery (MCA; R-MCA: p=0.003; L-MCA: p=0.002) and anterior cerebral artery (ACA; R-ACA: p=0.003; L-ACA: p=.001) was significantly reduced. Pulsatility index (PI) of MCA (p<0.001) and resistance index (RI) of ACA (R-ACA: p=0.009; L-ACA: p=0.008) were increased in alcohol-dependent subjects in comparison with healthy controls. In the active rTMS group, except L-MCA PI, significant differences were observed in values of MV, PI, and RI of both MCA and ACA following rTMS intervention; such changes were not evident in the sham rTMS group. The changes in mean difference in MV of L-MCA (p=0.006) and L-ACA (p=0.015) were statistically significant in the active rTMS group, in comparison with the sham group. Significant differences were also observed between the two groups postintervention, in RI of L-MCA (p=0.001) and ACA (R-ACA: p=0.010; L-ACA: p=0.015). Alcohol dependence may result in altered cerebral hemodynamic parameters, which can be improved with high-frequency rTMS application.

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Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Pages: 319 - 324
PubMed: 27056019

History

Received: 4 November 2015
Revision received: 10 February 2016
Accepted: 19 February 2016
Published online: 8 April 2016
Published in print: Fall 2016

Authors

Details

Biswa Ranjan Mishra, M.D.
From the Dept. of Psychiatry, All India Institute of Medical Sciences, Bhubaneswar (BRM); the Dept. of Pharmacology, All India Institute of Medical Sciences, Bhubaneswar (RM); and the Center for Cognitive Neurosciences, Central Institute of Psychiatry, Kanke, Ranchi, India (SHN).
Rituparna Maiti, M.D.
From the Dept. of Psychiatry, All India Institute of Medical Sciences, Bhubaneswar (BRM); the Dept. of Pharmacology, All India Institute of Medical Sciences, Bhubaneswar (RM); and the Center for Cognitive Neurosciences, Central Institute of Psychiatry, Kanke, Ranchi, India (SHN).
S. Haque Nizamie, M.D.
From the Dept. of Psychiatry, All India Institute of Medical Sciences, Bhubaneswar (BRM); the Dept. of Pharmacology, All India Institute of Medical Sciences, Bhubaneswar (RM); and the Center for Cognitive Neurosciences, Central Institute of Psychiatry, Kanke, Ranchi, India (SHN).

Notes

Send correspondence to Dr. Mishra; e-mail: [email protected]

Competing Interests

The authors report no financial relationships with commercial interests.

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