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Published Online: 8 April 2016

Conflict-Related Anterior Cingulate Functional Connectivity Is Associated With Past Suicidal Ideation and Behavior in Recent-Onset Psychotic Major Mood Disorders

Publication: The Journal of Neuropsychiatry and Clinical Neurosciences

Abstract

Suicidal ideation and behavior are highly prevalent in psychotic major mood disorders, yet their relationship to brain function remains unclear. Thirty patients with recent-onset of bipolar disorder type I (N=21) or major depressive disorder (N=9) with past psychosis were evaluated for past suicidal ideation/behavior and functional MRI during conflict-monitoring. Suicidal ideation was related to relatively higher dorsal anterior cingulate cortex (dACC)-seeded functional connectivity with dorsal fronto-parietal and inferior temporal-occipital cortex, as well as lower dACC connectivity with bilateral ventrolateral prefrontal cortex (PFC) and adjacent fronto-striatal regions. Past suicidal behavior was associated with lower dACC functional connectivity with dorsolateral PFC and premotor cortex, as well as temporal-parietal cortex.

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Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Pages: 299 - 305
PubMed: 27056021

History

Received: 21 December 2015
Revision received: 30 January 2016
Accepted: 18 February 2016
Published online: 8 April 2016
Published in print: Fall 2016

Authors

Details

Michael J. Minzenberg, M.D.
From the Dept. of Psychiatry, UC, San Francisco School of Medicine, San Francisco, CA (MJM, YC); the Center for Neuroscience, UC, Davis, Davis, CA (TAL); and the Dept. of Psychiatry, UC, Davis School of Medicine, Sacramento, CA (TAN, CSC).
Tyler A. Lesh, Ph.D.
From the Dept. of Psychiatry, UC, San Francisco School of Medicine, San Francisco, CA (MJM, YC); the Center for Neuroscience, UC, Davis, Davis, CA (TAL); and the Dept. of Psychiatry, UC, Davis School of Medicine, Sacramento, CA (TAN, CSC).
Tara A. Niendam, Ph.D.
From the Dept. of Psychiatry, UC, San Francisco School of Medicine, San Francisco, CA (MJM, YC); the Center for Neuroscience, UC, Davis, Davis, CA (TAL); and the Dept. of Psychiatry, UC, Davis School of Medicine, Sacramento, CA (TAN, CSC).
Yaoan Cheng, B.S.
From the Dept. of Psychiatry, UC, San Francisco School of Medicine, San Francisco, CA (MJM, YC); the Center for Neuroscience, UC, Davis, Davis, CA (TAL); and the Dept. of Psychiatry, UC, Davis School of Medicine, Sacramento, CA (TAN, CSC).
Cameron S. Carter, M.D.
From the Dept. of Psychiatry, UC, San Francisco School of Medicine, San Francisco, CA (MJM, YC); the Center for Neuroscience, UC, Davis, Davis, CA (TAL); and the Dept. of Psychiatry, UC, Davis School of Medicine, Sacramento, CA (TAN, CSC).

Notes

Send correspondence to Dr. Minzenberg; e-mail: [email protected]

Competing Interests

The authors report no financial relationships with commercial interests.

Funding Information

American Foundation for Suicide Prevention:
National Institute of Mental Health10.13039/100000025: MH059883
Doris Duke Charitable Foundation10.13039/100000862: 2009045

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