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Published Online: 28 April 2017

Intrathecal Thyroid Autoantibody Synthesis in a Subgroup of Patients With Schizophreniform Syndromes

Dominique Endres, M.D. [email protected], Rick Dersch, M.D., Benedikt Hochstuhl, Bernd Fiebich, Ph.D., Tilman Hottenrott, M.D., Evgeniy Perlov, M.D., Simon Maier, Ph.D., Benjamin Berger, M.D., Annette Baumgartner, M.D., Nils Venhoff, M.D., Oliver Stich, M.D., and Ludger Tebartz van Elst, M.D.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 29, Number 4
https://doi.org/10.1176/appi.neuropsych.16110296
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Abstract

Schizophreniform syndromes in combination with autoimmune thyroiditis and increased serum thyroid antibodies lead healthcare practitioners to consider a diagnosis of Hashimoto’s encephalopathy. To detect specific biomarkers, the authors analyzed whether intrathecal antithyroid antibody synthesis occurred in a subgroup of schizophreniform patients. In doing so, the authors analyzed thyroid antibodies in paired cerebrospinal fluid and serum samples from 100 schizophreniform patients. Increased antibody indices (AIs) for antithyroid peroxidase or antithyroglobulin autoantibodies in 13 schizophreniform patients were found. AIs were increased in 68% of the seropositive patients. These findings support the hypothesis that autoimmune processes may contribute to the pathophysiology in these patients.

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Information & Authors

Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 29 • Number 4 • Fall 2017
Pages: 365 - 374
PubMed: 28449636

History

Received: 3 November 2016
Revision received: 17 December 2016
Accepted: 11 January 2017
Published online: 28 April 2017
Published in print: Fall 2017

Keywords

  1. Schizophrenia
  2. antibody index
  3. thyroid peroxidase
  4. thyroglobulin
  5. Hashimoto’s encephalopathy

Authors

Affiliations

Dominique Endres, M.D. [email protected]
From the Section for Experimental Neuropsychiatry, Department for Psychiatry & Psychotherapy, University Medical Center Freiburg, Freiburg, Germany (DE, BH, BF, EP, SM, LTvE); the Department for Neurology, University Medical Center Freiburg, Freiburg, Germany (RD, TH, BB, AB, OS); and the Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, Germany (NV).
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Rick Dersch, M.D.
From the Section for Experimental Neuropsychiatry, Department for Psychiatry & Psychotherapy, University Medical Center Freiburg, Freiburg, Germany (DE, BH, BF, EP, SM, LTvE); the Department for Neurology, University Medical Center Freiburg, Freiburg, Germany (RD, TH, BB, AB, OS); and the Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, Germany (NV).
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Benedikt Hochstuhl
From the Section for Experimental Neuropsychiatry, Department for Psychiatry & Psychotherapy, University Medical Center Freiburg, Freiburg, Germany (DE, BH, BF, EP, SM, LTvE); the Department for Neurology, University Medical Center Freiburg, Freiburg, Germany (RD, TH, BB, AB, OS); and the Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, Germany (NV).
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Bernd Fiebich, Ph.D.
From the Section for Experimental Neuropsychiatry, Department for Psychiatry & Psychotherapy, University Medical Center Freiburg, Freiburg, Germany (DE, BH, BF, EP, SM, LTvE); the Department for Neurology, University Medical Center Freiburg, Freiburg, Germany (RD, TH, BB, AB, OS); and the Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, Germany (NV).
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Tilman Hottenrott, M.D.
From the Section for Experimental Neuropsychiatry, Department for Psychiatry & Psychotherapy, University Medical Center Freiburg, Freiburg, Germany (DE, BH, BF, EP, SM, LTvE); the Department for Neurology, University Medical Center Freiburg, Freiburg, Germany (RD, TH, BB, AB, OS); and the Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, Germany (NV).
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Evgeniy Perlov, M.D.
From the Section for Experimental Neuropsychiatry, Department for Psychiatry & Psychotherapy, University Medical Center Freiburg, Freiburg, Germany (DE, BH, BF, EP, SM, LTvE); the Department for Neurology, University Medical Center Freiburg, Freiburg, Germany (RD, TH, BB, AB, OS); and the Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, Germany (NV).
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Simon Maier, Ph.D.
From the Section for Experimental Neuropsychiatry, Department for Psychiatry & Psychotherapy, University Medical Center Freiburg, Freiburg, Germany (DE, BH, BF, EP, SM, LTvE); the Department for Neurology, University Medical Center Freiburg, Freiburg, Germany (RD, TH, BB, AB, OS); and the Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, Germany (NV).
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Benjamin Berger, M.D.
From the Section for Experimental Neuropsychiatry, Department for Psychiatry & Psychotherapy, University Medical Center Freiburg, Freiburg, Germany (DE, BH, BF, EP, SM, LTvE); the Department for Neurology, University Medical Center Freiburg, Freiburg, Germany (RD, TH, BB, AB, OS); and the Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, Germany (NV).
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Annette Baumgartner, M.D.
From the Section for Experimental Neuropsychiatry, Department for Psychiatry & Psychotherapy, University Medical Center Freiburg, Freiburg, Germany (DE, BH, BF, EP, SM, LTvE); the Department for Neurology, University Medical Center Freiburg, Freiburg, Germany (RD, TH, BB, AB, OS); and the Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, Germany (NV).
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Nils Venhoff, M.D.
From the Section for Experimental Neuropsychiatry, Department for Psychiatry & Psychotherapy, University Medical Center Freiburg, Freiburg, Germany (DE, BH, BF, EP, SM, LTvE); the Department for Neurology, University Medical Center Freiburg, Freiburg, Germany (RD, TH, BB, AB, OS); and the Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, Germany (NV).
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Oliver Stich, M.D.
From the Section for Experimental Neuropsychiatry, Department for Psychiatry & Psychotherapy, University Medical Center Freiburg, Freiburg, Germany (DE, BH, BF, EP, SM, LTvE); the Department for Neurology, University Medical Center Freiburg, Freiburg, Germany (RD, TH, BB, AB, OS); and the Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, Germany (NV).
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Ludger Tebartz van Elst, M.D.
From the Section for Experimental Neuropsychiatry, Department for Psychiatry & Psychotherapy, University Medical Center Freiburg, Freiburg, Germany (DE, BH, BF, EP, SM, LTvE); the Department for Neurology, University Medical Center Freiburg, Freiburg, Germany (RD, TH, BB, AB, OS); and the Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, Germany (NV).
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Notes

Send correspondence to Dr. Endres; e-mail: [email protected]

Author Contributions

Drs. Endres and Dersch share first authorship and contributed equally to this study.
Drs. Stich and Tebartz van Elst contributed equally to this study.

Competing Interests

BF has received grant and research support from Bayer Vital GmbH. TH has received travel grants from Bayer Vital GmbH and Novartis. BB has received travel grants from Bayer Vital GmbH, Ipsen Pharma GmbH, and Genzyme. AB has received consulting and lecture fees, as well as grant and research support, from Bayer Vital GmbH, Biogen Idec, Merck Serono, Novartis, Sanofi-Aventis, and Teva. NV has served on advisory boards of, has participated in lectures for, and/or received research or travel grants from AbbVie, GSK, Janssen-Cilag, Medac, Novartis, and Roche. OS has received consulting and lecture fees and grant and research support from Bayer Vital GmbH, Biogen Idec, Genzyme, Merck Serono, Novartis, Sanofi-Aventis, and Teva. LTvE has served on advisory boards of, has participated in lectures for, and/or received travel grants from Cyberonics, Eli Lilly, GlaxoSmithKline, Janssen, Janssen-Cilag, Novartis, Servier, Shire, and UCB. All other authors report no financial relationships with commercial interests.

Funding Information

Supported by the Department for Psychiatry and Psychotherapy of the University Medical Center Freiburg.

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