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Clinical Case Conference in Behavioral Neurology & Neuropsychiatry
Published Online: 14 October 2022

Case Study 3: A 58-Year-Old Woman Referred for Evaluation of Suspected Alzheimer Dementia

Jeffrey Maneval, M.D., Jared K. Woods, M.D., Ph.D., Mel B. Feany, M.D., Ph.D., Michael B. Miller, M.D., Ph.D., David A. Silbersweig, M.D., Seth A. Gale, M.D., Kirk R. Daffner, M.D., and Scott M. McGinnis, M.D. [email protected]Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 34, Number 4
https://doi.org/10.1176/appi.neuropsych.20220113
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Information & Authors

Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 34 • Number 4 • Fall 2022
Pages: 307 - 315

History

Received: 17 June 2022
Revision received: 15 August 2022
Accepted: 15 August 2022
Published in print: Fall 2022
Published online: 14 October 2022

Keywords

  1. Neuropathology
  2. Dementia with Lewy bodies
  3. Rapid eye movement sleep behavior disorder
  4. Parkinsonism
  5. Cerebrospinal fluid biomarkers
  6. Apolipoprotein E

Authors

Affiliations

Jeffrey Maneval, M.D.
Department of Neurology (Maneval, Silbersweig, Gale, Daffner, McGinnis) and Department of Psychiatry (Silbersweig), Center for Brain/Mind Medicine, and Department of Pathology (Woods, Feany, Miller), Brigham and Women’s Hospital, Harvard Medical School, Boston; Frontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (McGinnis).
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Jared K. Woods, M.D., Ph.D.
Department of Neurology (Maneval, Silbersweig, Gale, Daffner, McGinnis) and Department of Psychiatry (Silbersweig), Center for Brain/Mind Medicine, and Department of Pathology (Woods, Feany, Miller), Brigham and Women’s Hospital, Harvard Medical School, Boston; Frontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (McGinnis).
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Mel B. Feany, M.D., Ph.D.
Department of Neurology (Maneval, Silbersweig, Gale, Daffner, McGinnis) and Department of Psychiatry (Silbersweig), Center for Brain/Mind Medicine, and Department of Pathology (Woods, Feany, Miller), Brigham and Women’s Hospital, Harvard Medical School, Boston; Frontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (McGinnis).
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Michael B. Miller, M.D., Ph.D.
Department of Neurology (Maneval, Silbersweig, Gale, Daffner, McGinnis) and Department of Psychiatry (Silbersweig), Center for Brain/Mind Medicine, and Department of Pathology (Woods, Feany, Miller), Brigham and Women’s Hospital, Harvard Medical School, Boston; Frontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (McGinnis).
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David A. Silbersweig, M.D.
Department of Neurology (Maneval, Silbersweig, Gale, Daffner, McGinnis) and Department of Psychiatry (Silbersweig), Center for Brain/Mind Medicine, and Department of Pathology (Woods, Feany, Miller), Brigham and Women’s Hospital, Harvard Medical School, Boston; Frontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (McGinnis).
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Seth A. Gale, M.D.
Department of Neurology (Maneval, Silbersweig, Gale, Daffner, McGinnis) and Department of Psychiatry (Silbersweig), Center for Brain/Mind Medicine, and Department of Pathology (Woods, Feany, Miller), Brigham and Women’s Hospital, Harvard Medical School, Boston; Frontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (McGinnis).
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Kirk R. Daffner, M.D.
Department of Neurology (Maneval, Silbersweig, Gale, Daffner, McGinnis) and Department of Psychiatry (Silbersweig), Center for Brain/Mind Medicine, and Department of Pathology (Woods, Feany, Miller), Brigham and Women’s Hospital, Harvard Medical School, Boston; Frontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (McGinnis).
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Scott M. McGinnis, M.D. [email protected]
Department of Neurology (Maneval, Silbersweig, Gale, Daffner, McGinnis) and Department of Psychiatry (Silbersweig), Center for Brain/Mind Medicine, and Department of Pathology (Woods, Feany, Miller), Brigham and Women’s Hospital, Harvard Medical School, Boston; Frontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (McGinnis).
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Notes

Send correspondence to Dr. McGinnis ([email protected]).

Competing Interests

The authors report no financial relationships with commercial interests.
The authors have confirmed that details of the case have been disguised to protect patient privacy.

Funding Information

This work was supported in part by NIH grants K08 AG065502 and T32 HL007627 (to Dr. Miller).

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