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Clinical Case Conference in Behavioral Neurology & Neuropsychiatry
Published Online: 3 August 2022

Case Study 2: A 60-Year-Old Man With Progressive Deficits in Language Output

Kristina Thurin, M.D., Viharkumar Patel, M.D., David L. Perez, M.D., M.M.Sc., Bradford C. Dickerson, M.D., Daisy Hochberg, M.S., C.C.C.-S.L.P., Megan Quimby, M.S., C.C.C.-S.L.P., Michael B. Miller, M.D., Ph.D., Mel Feany, M.D., Ph.D., David Silbersweig, M.D., Scott M. McGinnis, M.D., Kirk R. Daffner, M.D., and Seth A. Gale, M.D. [email protected]Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 34, Number 3
https://doi.org/10.1176/appi.neuropsych.22010013
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Information & Authors

Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 34 • Number 3 • Summer 2022
Pages: 196 - 203
PubMed: 35921620

History

Received: 17 January 2022
Revision received: 31 March 2022
Accepted: 17 May 2022
Published in print: Summer 2022
Published online: 3 August 2022

Keywords

  1. Primary Progressive Aphasia
  2. Dynamic Aphasia
  3. Frontotemporal Lobar Degeneration
  4. FTLD-tau
  5. Pick’s Disease
  6. Clinicopathologic Correlation
  7. Neuropathology
  8. Aphasias and Related Disorders

Authors

Affiliations

Kristina Thurin, M.D.
Department of Psychiatry and Department of Neurology, Center for Cognitive and Memory Disorders, Ohio State University Wexner Medical Center, Columbus, Ohio (Thurin); Departments of Psychiatry (Thurin, Silbersweig) and Neurology (Thurin, McGinnis, Daffner, Gale), Center for Brain/Mind Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston; Department of Pathology, Division of Neuropathology, Brigham and Women’s Hospital, Harvard Medical School (Patel, Miller, Feany); Departments of Neurology and Psychiatry, Divisions of Behavioral Neurology and Neuropsychiatry, Massachusetts General Hospital, Harvard Medical School (Perez); Departments of Neurology and Psychiatry, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School (Dickerson, Hochberg, Quimby).
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Viharkumar Patel, M.D.
Department of Psychiatry and Department of Neurology, Center for Cognitive and Memory Disorders, Ohio State University Wexner Medical Center, Columbus, Ohio (Thurin); Departments of Psychiatry (Thurin, Silbersweig) and Neurology (Thurin, McGinnis, Daffner, Gale), Center for Brain/Mind Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston; Department of Pathology, Division of Neuropathology, Brigham and Women’s Hospital, Harvard Medical School (Patel, Miller, Feany); Departments of Neurology and Psychiatry, Divisions of Behavioral Neurology and Neuropsychiatry, Massachusetts General Hospital, Harvard Medical School (Perez); Departments of Neurology and Psychiatry, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School (Dickerson, Hochberg, Quimby).
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David L. Perez, M.D., M.M.Sc.
Department of Psychiatry and Department of Neurology, Center for Cognitive and Memory Disorders, Ohio State University Wexner Medical Center, Columbus, Ohio (Thurin); Departments of Psychiatry (Thurin, Silbersweig) and Neurology (Thurin, McGinnis, Daffner, Gale), Center for Brain/Mind Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston; Department of Pathology, Division of Neuropathology, Brigham and Women’s Hospital, Harvard Medical School (Patel, Miller, Feany); Departments of Neurology and Psychiatry, Divisions of Behavioral Neurology and Neuropsychiatry, Massachusetts General Hospital, Harvard Medical School (Perez); Departments of Neurology and Psychiatry, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School (Dickerson, Hochberg, Quimby).
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Bradford C. Dickerson, M.D.
Department of Psychiatry and Department of Neurology, Center for Cognitive and Memory Disorders, Ohio State University Wexner Medical Center, Columbus, Ohio (Thurin); Departments of Psychiatry (Thurin, Silbersweig) and Neurology (Thurin, McGinnis, Daffner, Gale), Center for Brain/Mind Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston; Department of Pathology, Division of Neuropathology, Brigham and Women’s Hospital, Harvard Medical School (Patel, Miller, Feany); Departments of Neurology and Psychiatry, Divisions of Behavioral Neurology and Neuropsychiatry, Massachusetts General Hospital, Harvard Medical School (Perez); Departments of Neurology and Psychiatry, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School (Dickerson, Hochberg, Quimby).
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Daisy Hochberg, M.S., C.C.C.-S.L.P.
Department of Psychiatry and Department of Neurology, Center for Cognitive and Memory Disorders, Ohio State University Wexner Medical Center, Columbus, Ohio (Thurin); Departments of Psychiatry (Thurin, Silbersweig) and Neurology (Thurin, McGinnis, Daffner, Gale), Center for Brain/Mind Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston; Department of Pathology, Division of Neuropathology, Brigham and Women’s Hospital, Harvard Medical School (Patel, Miller, Feany); Departments of Neurology and Psychiatry, Divisions of Behavioral Neurology and Neuropsychiatry, Massachusetts General Hospital, Harvard Medical School (Perez); Departments of Neurology and Psychiatry, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School (Dickerson, Hochberg, Quimby).
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Megan Quimby, M.S., C.C.C.-S.L.P.
Department of Psychiatry and Department of Neurology, Center for Cognitive and Memory Disorders, Ohio State University Wexner Medical Center, Columbus, Ohio (Thurin); Departments of Psychiatry (Thurin, Silbersweig) and Neurology (Thurin, McGinnis, Daffner, Gale), Center for Brain/Mind Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston; Department of Pathology, Division of Neuropathology, Brigham and Women’s Hospital, Harvard Medical School (Patel, Miller, Feany); Departments of Neurology and Psychiatry, Divisions of Behavioral Neurology and Neuropsychiatry, Massachusetts General Hospital, Harvard Medical School (Perez); Departments of Neurology and Psychiatry, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School (Dickerson, Hochberg, Quimby).
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Michael B. Miller, M.D., Ph.D.
Department of Psychiatry and Department of Neurology, Center for Cognitive and Memory Disorders, Ohio State University Wexner Medical Center, Columbus, Ohio (Thurin); Departments of Psychiatry (Thurin, Silbersweig) and Neurology (Thurin, McGinnis, Daffner, Gale), Center for Brain/Mind Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston; Department of Pathology, Division of Neuropathology, Brigham and Women’s Hospital, Harvard Medical School (Patel, Miller, Feany); Departments of Neurology and Psychiatry, Divisions of Behavioral Neurology and Neuropsychiatry, Massachusetts General Hospital, Harvard Medical School (Perez); Departments of Neurology and Psychiatry, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School (Dickerson, Hochberg, Quimby).
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Mel Feany, M.D., Ph.D.
Department of Psychiatry and Department of Neurology, Center for Cognitive and Memory Disorders, Ohio State University Wexner Medical Center, Columbus, Ohio (Thurin); Departments of Psychiatry (Thurin, Silbersweig) and Neurology (Thurin, McGinnis, Daffner, Gale), Center for Brain/Mind Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston; Department of Pathology, Division of Neuropathology, Brigham and Women’s Hospital, Harvard Medical School (Patel, Miller, Feany); Departments of Neurology and Psychiatry, Divisions of Behavioral Neurology and Neuropsychiatry, Massachusetts General Hospital, Harvard Medical School (Perez); Departments of Neurology and Psychiatry, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School (Dickerson, Hochberg, Quimby).
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David Silbersweig, M.D.
Department of Psychiatry and Department of Neurology, Center for Cognitive and Memory Disorders, Ohio State University Wexner Medical Center, Columbus, Ohio (Thurin); Departments of Psychiatry (Thurin, Silbersweig) and Neurology (Thurin, McGinnis, Daffner, Gale), Center for Brain/Mind Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston; Department of Pathology, Division of Neuropathology, Brigham and Women’s Hospital, Harvard Medical School (Patel, Miller, Feany); Departments of Neurology and Psychiatry, Divisions of Behavioral Neurology and Neuropsychiatry, Massachusetts General Hospital, Harvard Medical School (Perez); Departments of Neurology and Psychiatry, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School (Dickerson, Hochberg, Quimby).
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Scott M. McGinnis, M.D.
Department of Psychiatry and Department of Neurology, Center for Cognitive and Memory Disorders, Ohio State University Wexner Medical Center, Columbus, Ohio (Thurin); Departments of Psychiatry (Thurin, Silbersweig) and Neurology (Thurin, McGinnis, Daffner, Gale), Center for Brain/Mind Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston; Department of Pathology, Division of Neuropathology, Brigham and Women’s Hospital, Harvard Medical School (Patel, Miller, Feany); Departments of Neurology and Psychiatry, Divisions of Behavioral Neurology and Neuropsychiatry, Massachusetts General Hospital, Harvard Medical School (Perez); Departments of Neurology and Psychiatry, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School (Dickerson, Hochberg, Quimby).
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Kirk R. Daffner, M.D.
Department of Psychiatry and Department of Neurology, Center for Cognitive and Memory Disorders, Ohio State University Wexner Medical Center, Columbus, Ohio (Thurin); Departments of Psychiatry (Thurin, Silbersweig) and Neurology (Thurin, McGinnis, Daffner, Gale), Center for Brain/Mind Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston; Department of Pathology, Division of Neuropathology, Brigham and Women’s Hospital, Harvard Medical School (Patel, Miller, Feany); Departments of Neurology and Psychiatry, Divisions of Behavioral Neurology and Neuropsychiatry, Massachusetts General Hospital, Harvard Medical School (Perez); Departments of Neurology and Psychiatry, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School (Dickerson, Hochberg, Quimby).
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Seth A. Gale, M.D. [email protected]
Department of Psychiatry and Department of Neurology, Center for Cognitive and Memory Disorders, Ohio State University Wexner Medical Center, Columbus, Ohio (Thurin); Departments of Psychiatry (Thurin, Silbersweig) and Neurology (Thurin, McGinnis, Daffner, Gale), Center for Brain/Mind Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston; Department of Pathology, Division of Neuropathology, Brigham and Women’s Hospital, Harvard Medical School (Patel, Miller, Feany); Departments of Neurology and Psychiatry, Divisions of Behavioral Neurology and Neuropsychiatry, Massachusetts General Hospital, Harvard Medical School (Perez); Departments of Neurology and Psychiatry, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School (Dickerson, Hochberg, Quimby).
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Notes

Send correspondence to Dr. Gale ([email protected]).

Competing Interests

Dr. Perez has received research funding from NIH and the Sidney R. Baer, Jr. Foundation; he serves on the editorial boards of Epilepsy & Behavior and Brain and Behavior; he has received honoraria for continuing education lectures; and he receives royalties from Springer for a functional movement disorder textbook. Dr. Quimby receives an annual salary from Massachusetts General Hospital. Dr. Silbersweig is co-founder and chair of Ceretype Neuromedicine; he is a shareholder with Buoyant; and he serves as a Harvard Medical School CME course director. The other authors report no financial relationships with commercial interests.

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