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Published Online: 1 October 2011

The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Update 2010 on the Treatment of Acute Bipolar Depression

Heinz Grunze [email protected], Eduard Vieta, Guy M. Goodwin, Charles Bowden, Rasmus W. Licht, Hans-Jürgen Möller, and Siegfried Kasper WFSBP Task Force on Treatment Guidelines for Bipolar DisordersAuthors Info & Affiliations
Publication: FOCUS
Volume 9, Number 4
https://doi.org/10.1176/foc.9.4.foc500
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Abstract

Objectives: These guidelines are based on a first edition that was published in 2002, and have been edited and updated with the available scientific evidence until September 2009. Their purpose is to supply a systematic overview of all scientific evidence pertaining to the treatment of acute bipolar depression in adults. Methods: The data used for these guidelines have been extracted from a MEDLINE and EMBASE search, from the clinical trial database clinicaltrials.gov, from recent proceedings of key conferences, and from various national and international treatment guidelines. Their scientific rigor was categorised into six levels of evidence (A–F). As these guidelines are intended for clinical use, the scientific evidence was finally assigned different grades of recommendation to ensure practicability. Results: We identified 10 pharmacological monotherapies or combination treatments with at least limited positive evidence for efficacy in bipolar depression, several of them still experimental and backed up only by a single study. Only one medication was considered to be sufficiently studied to merit full positive evidence. Conclusions: Although major advances have been made since the first edition of this guideline in 2002, there are many areas which still need more intense research to optimize treatment. The majority of treatment recommendations is still based on limited data and leaves considerable areas of uncertainty.
(Reprinted with permission from The World Journal of Biological Psychiatry, 2010; 11:81–109)

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FOCUS
Volume 9 • Number 4 • Fall 2011
Pages: 500 - 525

History

Published online: 1 October 2011
Published in print: Fall 2011

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WFSBP Task Force on Treatment Guidelines for Bipolar Disorders
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Notes

Address correspondence to Prof. Dr. Heinz Grunze, Institute of Neuroscience, Department of Psychiatry, RVI, Newcastle University, Newcastle upon Tyne NE1 4LP, UK. Tel: +44 191 282 5765. Fax: +44 191 222 6162. E-mail: [email protected]
*Chairman: Siegfried Kasper (Austria), Co-Chairman: Guy Goodwin (United Kingdom), Co-Chairman: Charles Bowden (USA), Secretary: Heinz Grunze (United Kingdom), WFSBP Past-President: Hans-Jürgen Möller (Germany), Rasmus W. Licht (Denmark), Eduard Vieta (Spain), Hagop Akiskal (USA), José Luis Ayuso-Gutierrez (Spain), Michael Bauer (Germany), Per Bech (Denmark), Michael Berk (Australia), Istvan Bitter (Hungary), Graham Burrows (Australia), Joseph Calabrese (USA), Giovanni Cassano (Italy), Marcelo Cetkovich-Bakmas (Argentina), John C. Cookson (UK), I. Nicol Ferrier (UK), Wagner F.Gattaz (Brazil), Frederik K. Goodwin (USA), Gerhard Heinze (Mexico), Teruhiko Higuchi (Japan), Robert M. Hirschfeld (USA), Cyril Hoeschl (Czech Republik), Edith Holsboer-Trachsler (Switzerland), Kay Redfield Jamison (USA), Cornelius Katona (UK), Martin Keller (USA), E. Kostukova (Russia), Hever Kruger (Peru), Parmanand Kulhara (India), Yves Lecruibier (France), Veronica Larach (Chile), Odd Lingjaerde (Norway), Henrik Lublin (Denmark), Mario Maj (Italy), Julien Mendlewicz (Belgium), Roberto Miranda Camacho (Mexico), Philip Mitchell (Australia), S. Mosolov (Russia), Stuart Montgomery (UK), Charles Nemeroff (USA), Willem Nolen (The Netherlands), Eugene S. Paykel (UK), Robert M. Post (USA), Stanislaw Puzynski (Poland), Zoltan Rihmer (Hungary), Janusz K. Rybakowski (Poland), Per Vestergaard (Denmark), Peter C. Whybrow (USA), Kazuo Yamada (Japan)

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