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Published Online: 1 August 1999

Risperidone Treatment of Behavioral Disturbances in Outpatients With Dementia

Michael C. Irizarry, M.D., S. Nassir Ghaemi, M.D., Erica R. Lee-Cherry, B.A., Teresa Gomez-Isla, M.D., Ph.D., Giuliano Binetti, M.D., Bradley T. Hyman, M.D., Ph.D., and John H. Growdon, M.D.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 11, Number 3
https://doi.org/10.1176/jnp.11.3.336
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Abstract

The authors retrospectively assessed the effectiveness and side effects of risperidone used to treat behavioral disturbances in elderly outpatients with dementia. In 41 patients treated with risperidone 1.8±1.4 mg/day, there was complete suppression of the target symptom in 15%, partial response in 41%, and no response in 44%. Risperidone appeared equally effective in treating agitation and psychosis. New or worsening extrapyramidal side effects (EPS) occurred in 32%, associated with longer duration of treatment and possibly with concomitant use of serotonergic antidepressants. Risperidone was a useful adjunct in the treatment of agitation and psychosis in outpatients with dementia but was limited by EPS in about one-third of patients.

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Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 11 • Number 3 • August 1999
Pages: 336 - 342
PubMed: 10440009

History

Published online: 1 August 1999
Published in print: August 1999

Authors

Details

Michael C. Irizarry, M.D.
Received December 9, 1998; revised March 5, 1999; accepted March 17, 1999. From the Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; and Center on Neuroscience, Medical Progress, and Society, Department of Psychiatry, The George Washington University, Washington, DC. Address correspondence to Dr. Irizarry, Alzheimer Disease Research Unit, Massachusetts General Hospital-East, CNY 6028, 149 13th Street, Charlestown, MA 02129.
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S. Nassir Ghaemi, M.D.
Received December 9, 1998; revised March 5, 1999; accepted March 17, 1999. From the Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; and Center on Neuroscience, Medical Progress, and Society, Department of Psychiatry, The George Washington University, Washington, DC. Address correspondence to Dr. Irizarry, Alzheimer Disease Research Unit, Massachusetts General Hospital-East, CNY 6028, 149 13th Street, Charlestown, MA 02129.
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Erica R. Lee-Cherry, B.A.
Received December 9, 1998; revised March 5, 1999; accepted March 17, 1999. From the Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; and Center on Neuroscience, Medical Progress, and Society, Department of Psychiatry, The George Washington University, Washington, DC. Address correspondence to Dr. Irizarry, Alzheimer Disease Research Unit, Massachusetts General Hospital-East, CNY 6028, 149 13th Street, Charlestown, MA 02129.
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Teresa Gomez-Isla, M.D., Ph.D.
Received December 9, 1998; revised March 5, 1999; accepted March 17, 1999. From the Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; and Center on Neuroscience, Medical Progress, and Society, Department of Psychiatry, The George Washington University, Washington, DC. Address correspondence to Dr. Irizarry, Alzheimer Disease Research Unit, Massachusetts General Hospital-East, CNY 6028, 149 13th Street, Charlestown, MA 02129.
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Giuliano Binetti, M.D.
Received December 9, 1998; revised March 5, 1999; accepted March 17, 1999. From the Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; and Center on Neuroscience, Medical Progress, and Society, Department of Psychiatry, The George Washington University, Washington, DC. Address correspondence to Dr. Irizarry, Alzheimer Disease Research Unit, Massachusetts General Hospital-East, CNY 6028, 149 13th Street, Charlestown, MA 02129.
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Bradley T. Hyman, M.D., Ph.D.
Received December 9, 1998; revised March 5, 1999; accepted March 17, 1999. From the Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; and Center on Neuroscience, Medical Progress, and Society, Department of Psychiatry, The George Washington University, Washington, DC. Address correspondence to Dr. Irizarry, Alzheimer Disease Research Unit, Massachusetts General Hospital-East, CNY 6028, 149 13th Street, Charlestown, MA 02129.
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John H. Growdon, M.D.
Received December 9, 1998; revised March 5, 1999; accepted March 17, 1999. From the Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; and Center on Neuroscience, Medical Progress, and Society, Department of Psychiatry, The George Washington University, Washington, DC. Address correspondence to Dr. Irizarry, Alzheimer Disease Research Unit, Massachusetts General Hospital-East, CNY 6028, 149 13th Street, Charlestown, MA 02129.
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