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Published Online: 1 August 2000

How Coil–Cortex Distance Relates to Age, Motor Threshold, and Antidepressant Response to Repetitive Transcranial Magnetic Stimulation

F. Andrew Kozel, M.D., Ziad Nahas, M.D., Cart deBrux, B.S., Monica Molloy, M.S.N., Jeffrey P. Lorberbaum, M.D., Daryl Bohning, Ph.D., S. Craig Risch, M.D., and Mark S. George, M.D.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 12, Number 3
https://doi.org/10.1176/jnp.12.3.376
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Abstract

Repetitive transcranial magnetic stimulation (rTMS) is a tool with antidepressant potential that uses a coil placed on the scalp to produce a powerful magnetic field that directly stimulates only the outermost cortex. MRI scans were obtained in 29 depressed adults involved in an rTMS antidepressant clinical treatment. These scans were analyzed to investigate the effect of distance from coil to cortex on clinical parameters. Longer motor cortex distance, but not prefrontal distance, strongly correlated with increased motor threshold (P<0.01). Clinical antidepressant response did not correlate with either distance. The rTMS antidepressant responders, however, were significantly younger (t=–2.430, P<0.05), and there appears to be a maximum threshold of age and distance to prefrontal cortex for response.

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Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 12 • Number 3 • August 2000
Pages: 376 - 384
PubMed: 10956572

History

Published online: 1 August 2000
Published in print: August 2000

Authors

Affiliations

F. Andrew Kozel, M.D.
Received August 24, 1999; revised January 12, 2000; accepted January 27, 2000. From the Functional Neuroimaging Division and the Brain Magnetic Stimulation Laboratories, Departments of Psychiatry, Radiology, and Neurology, Medical University of South Carolina; and Psychiatry Department, Ralph H. Johnson VA Medical Center, Charleston, South Carolina. Address correspondence to Dr. Kozel, MUSC Psychiatry Department, 67 President Street, P.O. Box 250861, Charleston, SC 29425; e-mail: [email protected]
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Ziad Nahas, M.D.
Received August 24, 1999; revised January 12, 2000; accepted January 27, 2000. From the Functional Neuroimaging Division and the Brain Magnetic Stimulation Laboratories, Departments of Psychiatry, Radiology, and Neurology, Medical University of South Carolina; and Psychiatry Department, Ralph H. Johnson VA Medical Center, Charleston, South Carolina. Address correspondence to Dr. Kozel, MUSC Psychiatry Department, 67 President Street, P.O. Box 250861, Charleston, SC 29425; e-mail: [email protected]
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Cart deBrux, B.S.
Received August 24, 1999; revised January 12, 2000; accepted January 27, 2000. From the Functional Neuroimaging Division and the Brain Magnetic Stimulation Laboratories, Departments of Psychiatry, Radiology, and Neurology, Medical University of South Carolina; and Psychiatry Department, Ralph H. Johnson VA Medical Center, Charleston, South Carolina. Address correspondence to Dr. Kozel, MUSC Psychiatry Department, 67 President Street, P.O. Box 250861, Charleston, SC 29425; e-mail: [email protected]
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Monica Molloy, M.S.N.
Received August 24, 1999; revised January 12, 2000; accepted January 27, 2000. From the Functional Neuroimaging Division and the Brain Magnetic Stimulation Laboratories, Departments of Psychiatry, Radiology, and Neurology, Medical University of South Carolina; and Psychiatry Department, Ralph H. Johnson VA Medical Center, Charleston, South Carolina. Address correspondence to Dr. Kozel, MUSC Psychiatry Department, 67 President Street, P.O. Box 250861, Charleston, SC 29425; e-mail: [email protected]
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Jeffrey P. Lorberbaum, M.D.
Received August 24, 1999; revised January 12, 2000; accepted January 27, 2000. From the Functional Neuroimaging Division and the Brain Magnetic Stimulation Laboratories, Departments of Psychiatry, Radiology, and Neurology, Medical University of South Carolina; and Psychiatry Department, Ralph H. Johnson VA Medical Center, Charleston, South Carolina. Address correspondence to Dr. Kozel, MUSC Psychiatry Department, 67 President Street, P.O. Box 250861, Charleston, SC 29425; e-mail: [email protected]
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Daryl Bohning, Ph.D.
Received August 24, 1999; revised January 12, 2000; accepted January 27, 2000. From the Functional Neuroimaging Division and the Brain Magnetic Stimulation Laboratories, Departments of Psychiatry, Radiology, and Neurology, Medical University of South Carolina; and Psychiatry Department, Ralph H. Johnson VA Medical Center, Charleston, South Carolina. Address correspondence to Dr. Kozel, MUSC Psychiatry Department, 67 President Street, P.O. Box 250861, Charleston, SC 29425; e-mail: [email protected]
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S. Craig Risch, M.D.
Received August 24, 1999; revised January 12, 2000; accepted January 27, 2000. From the Functional Neuroimaging Division and the Brain Magnetic Stimulation Laboratories, Departments of Psychiatry, Radiology, and Neurology, Medical University of South Carolina; and Psychiatry Department, Ralph H. Johnson VA Medical Center, Charleston, South Carolina. Address correspondence to Dr. Kozel, MUSC Psychiatry Department, 67 President Street, P.O. Box 250861, Charleston, SC 29425; e-mail: [email protected]
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Mark S. George, M.D.
Received August 24, 1999; revised January 12, 2000; accepted January 27, 2000. From the Functional Neuroimaging Division and the Brain Magnetic Stimulation Laboratories, Departments of Psychiatry, Radiology, and Neurology, Medical University of South Carolina; and Psychiatry Department, Ralph H. Johnson VA Medical Center, Charleston, South Carolina. Address correspondence to Dr. Kozel, MUSC Psychiatry Department, 67 President Street, P.O. Box 250861, Charleston, SC 29425; e-mail: [email protected]
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