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Published Online: 1 February 2005

Cognitive Impairment Associated With Major Depression Following Mild and Moderate Traumatic Brain Injury

Mark J. Rapoport, M.D., F.R.C.P.C., Scott McCullagh, M.D., F.R.C.P.C., Prathiba Shammi, Ph.D., and Anthony Feinstein, Ph.D., F.R.C.P.C.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 17, Number 1
https://doi.org/10.1176/jnp.17.1.61
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Abstract

Traumatic brain injury (TBI) and major depression are neuropsychiatric conditions that have been associated with cognitive dysfunction. The aim of this study was to explore the relationship between major depression and cognitive impairment following mild and moderate TBI. Seventy-four TBI patients were assessed for the presence of major depression using the Structured Clinical Interview for the DSM-IV and completed a neurocognitive assessment battery. Subjects with major depression (28.4%), compared to those without, were found to have significantly lower scores on measures of working memory, processing speed, verbal memory and executive function. Potential mechanisms and implications for treatment are discussed.

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Information & Authors

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Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 17 • Number 1 • February 2005
Pages: 61 - 65
PubMed: 15746484

History

Published online: 1 February 2005
Published in print: February 2005

Authors

Details

Mark J. Rapoport, M.D., F.R.C.P.C.
Received April 11, 2003; revised June 10, 2003; accepted July 17, 2003. From the Department of Psychiatry and Traumatic Brain Injury Clinic, Sunnybrook and Women’s College Health Sciences Centre, University of Toronto, Toronto, Ontario. Department of Psychology, Baycrest Centre for Geriatric Care, Toronto, Ontario. Address correspondence to Dr. Rapoport, FG37, Sunnybrook and Women’s College Health Sciences Centre, 2075 Bayview Ave., Toronto, ON, M4N 3M5, 416-480-4085; [email protected] (E-mail).
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Scott McCullagh, M.D., F.R.C.P.C.
Received April 11, 2003; revised June 10, 2003; accepted July 17, 2003. From the Department of Psychiatry and Traumatic Brain Injury Clinic, Sunnybrook and Women’s College Health Sciences Centre, University of Toronto, Toronto, Ontario. Department of Psychology, Baycrest Centre for Geriatric Care, Toronto, Ontario. Address correspondence to Dr. Rapoport, FG37, Sunnybrook and Women’s College Health Sciences Centre, 2075 Bayview Ave., Toronto, ON, M4N 3M5, 416-480-4085; [email protected] (E-mail).
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Prathiba Shammi, Ph.D.
Received April 11, 2003; revised June 10, 2003; accepted July 17, 2003. From the Department of Psychiatry and Traumatic Brain Injury Clinic, Sunnybrook and Women’s College Health Sciences Centre, University of Toronto, Toronto, Ontario. Department of Psychology, Baycrest Centre for Geriatric Care, Toronto, Ontario. Address correspondence to Dr. Rapoport, FG37, Sunnybrook and Women’s College Health Sciences Centre, 2075 Bayview Ave., Toronto, ON, M4N 3M5, 416-480-4085; [email protected] (E-mail).
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Anthony Feinstein, Ph.D., F.R.C.P.C.
Received April 11, 2003; revised June 10, 2003; accepted July 17, 2003. From the Department of Psychiatry and Traumatic Brain Injury Clinic, Sunnybrook and Women’s College Health Sciences Centre, University of Toronto, Toronto, Ontario. Department of Psychology, Baycrest Centre for Geriatric Care, Toronto, Ontario. Address correspondence to Dr. Rapoport, FG37, Sunnybrook and Women’s College Health Sciences Centre, 2075 Bayview Ave., Toronto, ON, M4N 3M5, 416-480-4085; [email protected] (E-mail).
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