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Published Online: 1 May 2005

Oxidative Stress During Treatment With First- and Second-Generation Antipsychotics

Stefan Kropp, M.D., Veronika Kern, M.D., Kirsten Lange, M.D., Detlef Degner, M.D., Göran Hajak, M.D., Johannes Kornhuber, M.D., Eckart Rüther, M.D., Hinderk M. Emrich, M.D., Ph.D., Udo Schneider, M.D., and Stefan Bleich, M.D.Authors Info & Affiliations
Publication: The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 17, Number 2
https://doi.org/10.1176/jnp.17.2.227
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Abstract

Neurotoxicity of first-generation antipsychotics (FGAs) may be involved in lipid peroxidation, which is the pathogenesis of extrapyramidal symptoms, including tardive dyskinesia (TD). Blood samples at day 0, 7, and 21 drawn from patients taking antipsychotics were analyzed for malondialdehyde (MDA) in plasma, a marker of lipid peroxidation, by high-performance liquid chromatography. Of 115 patients enrolled, 92 patients completed the study. Most MDA levels were within normal ranges (<1.0 μmol/liter). Malondialdehyde levels in patients receiving clozapine (p=0.002), quetiapine (p=0.003), amisulpride (p=0.008), and risperidone (p=0.008) were significantly lower than within the first generation antipsychotic group. The authors conclude that lipid peroxidation is significantly higher in treatment with FGAs.

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Information & Authors

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Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Volume 17 • Number 2 • May 2005
Pages: 227 - 231
PubMed: 15939978

History

Published online: 1 May 2005
Published in print: May 2005

Authors

Affiliations

Stefan Kropp, M.D.
Received August 4, 2003; revised December 8, 2003; accepted March 16, 2004. From the Department of Clinical Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany; the Department of Psychiatry and Psychotherapy, University Göttingen, Göttingen, Germany; the Department of Psychiatry and Psychotherapy, University Regensburg, Regensburg, Germany; the Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nuremberg, Nuremberg, Germany. Address correspondence to Dr. Kropp, Klinische Psychiatrie und Psychotherapie, Medizinische Hochschule Hannover, OE 7117, Carl-Neuberg-Str. 1, 30625 Hannover, Germany; [email protected] (E-mail).
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Veronika Kern, M.D.
Received August 4, 2003; revised December 8, 2003; accepted March 16, 2004. From the Department of Clinical Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany; the Department of Psychiatry and Psychotherapy, University Göttingen, Göttingen, Germany; the Department of Psychiatry and Psychotherapy, University Regensburg, Regensburg, Germany; the Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nuremberg, Nuremberg, Germany. Address correspondence to Dr. Kropp, Klinische Psychiatrie und Psychotherapie, Medizinische Hochschule Hannover, OE 7117, Carl-Neuberg-Str. 1, 30625 Hannover, Germany; [email protected] (E-mail).
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Kirsten Lange, M.D.
Received August 4, 2003; revised December 8, 2003; accepted March 16, 2004. From the Department of Clinical Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany; the Department of Psychiatry and Psychotherapy, University Göttingen, Göttingen, Germany; the Department of Psychiatry and Psychotherapy, University Regensburg, Regensburg, Germany; the Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nuremberg, Nuremberg, Germany. Address correspondence to Dr. Kropp, Klinische Psychiatrie und Psychotherapie, Medizinische Hochschule Hannover, OE 7117, Carl-Neuberg-Str. 1, 30625 Hannover, Germany; [email protected] (E-mail).
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Detlef Degner, M.D.
Received August 4, 2003; revised December 8, 2003; accepted March 16, 2004. From the Department of Clinical Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany; the Department of Psychiatry and Psychotherapy, University Göttingen, Göttingen, Germany; the Department of Psychiatry and Psychotherapy, University Regensburg, Regensburg, Germany; the Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nuremberg, Nuremberg, Germany. Address correspondence to Dr. Kropp, Klinische Psychiatrie und Psychotherapie, Medizinische Hochschule Hannover, OE 7117, Carl-Neuberg-Str. 1, 30625 Hannover, Germany; [email protected] (E-mail).
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Göran Hajak, M.D.
Received August 4, 2003; revised December 8, 2003; accepted March 16, 2004. From the Department of Clinical Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany; the Department of Psychiatry and Psychotherapy, University Göttingen, Göttingen, Germany; the Department of Psychiatry and Psychotherapy, University Regensburg, Regensburg, Germany; the Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nuremberg, Nuremberg, Germany. Address correspondence to Dr. Kropp, Klinische Psychiatrie und Psychotherapie, Medizinische Hochschule Hannover, OE 7117, Carl-Neuberg-Str. 1, 30625 Hannover, Germany; [email protected] (E-mail).
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Johannes Kornhuber, M.D.
Received August 4, 2003; revised December 8, 2003; accepted March 16, 2004. From the Department of Clinical Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany; the Department of Psychiatry and Psychotherapy, University Göttingen, Göttingen, Germany; the Department of Psychiatry and Psychotherapy, University Regensburg, Regensburg, Germany; the Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nuremberg, Nuremberg, Germany. Address correspondence to Dr. Kropp, Klinische Psychiatrie und Psychotherapie, Medizinische Hochschule Hannover, OE 7117, Carl-Neuberg-Str. 1, 30625 Hannover, Germany; [email protected] (E-mail).
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Eckart Rüther, M.D.
Received August 4, 2003; revised December 8, 2003; accepted March 16, 2004. From the Department of Clinical Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany; the Department of Psychiatry and Psychotherapy, University Göttingen, Göttingen, Germany; the Department of Psychiatry and Psychotherapy, University Regensburg, Regensburg, Germany; the Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nuremberg, Nuremberg, Germany. Address correspondence to Dr. Kropp, Klinische Psychiatrie und Psychotherapie, Medizinische Hochschule Hannover, OE 7117, Carl-Neuberg-Str. 1, 30625 Hannover, Germany; [email protected] (E-mail).
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Hinderk M. Emrich, M.D., Ph.D.
Received August 4, 2003; revised December 8, 2003; accepted March 16, 2004. From the Department of Clinical Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany; the Department of Psychiatry and Psychotherapy, University Göttingen, Göttingen, Germany; the Department of Psychiatry and Psychotherapy, University Regensburg, Regensburg, Germany; the Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nuremberg, Nuremberg, Germany. Address correspondence to Dr. Kropp, Klinische Psychiatrie und Psychotherapie, Medizinische Hochschule Hannover, OE 7117, Carl-Neuberg-Str. 1, 30625 Hannover, Germany; [email protected] (E-mail).
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Udo Schneider, M.D.
Received August 4, 2003; revised December 8, 2003; accepted March 16, 2004. From the Department of Clinical Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany; the Department of Psychiatry and Psychotherapy, University Göttingen, Göttingen, Germany; the Department of Psychiatry and Psychotherapy, University Regensburg, Regensburg, Germany; the Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nuremberg, Nuremberg, Germany. Address correspondence to Dr. Kropp, Klinische Psychiatrie und Psychotherapie, Medizinische Hochschule Hannover, OE 7117, Carl-Neuberg-Str. 1, 30625 Hannover, Germany; [email protected] (E-mail).
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Stefan Bleich, M.D.
Received August 4, 2003; revised December 8, 2003; accepted March 16, 2004. From the Department of Clinical Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany; the Department of Psychiatry and Psychotherapy, University Göttingen, Göttingen, Germany; the Department of Psychiatry and Psychotherapy, University Regensburg, Regensburg, Germany; the Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University Erlangen-Nuremberg, Nuremberg, Germany. Address correspondence to Dr. Kropp, Klinische Psychiatrie und Psychotherapie, Medizinische Hochschule Hannover, OE 7117, Carl-Neuberg-Str. 1, 30625 Hannover, Germany; [email protected] (E-mail).
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