A Report of Successful Treatment of Psychosis in Epilepsy With Risperidone

A 42-year-old Caucasian male was diagnosed between the ages of 3 and 5 years with complex partial seizure disorder after a traumatic brain injury and he had received antiepileptic medications. The patient was the only sibling to a couple who did not have a family history of seizure disorder or other neurological disease or psychiatric illness. He had borderline intellectual functioning, received special education, attended vocational school, and was able to hold a part-time job.

At the age of 37, the patient experienced increased frequency of his seizure activity (6 to 8 incidents of activity per month), despite his adherence to the antiepileptic medication regimen. When his antiepileptic medications were adjusted by his neurologist, he reported a decrease in frequency of his seizure activity (none or 1 to 2 incidents per month).

At that time, he started having episodes of auditory hallucinations, hearing incoherent voices and paranoid delusions, and believing that people are against him. No history of affective flattening or thought blocking or lack of motivation or social withdrawal was reported.

His magnetic resonance image of the head was normal and his electroencephalogram indicated slowing and sharp waves originating in the right temporal region. His CBC and blood chemistries were within normal limits. His urine toxicology was negative.

The patient was hospitalized for the above-noted psychotic symptoms seven times in 3 years. He was prescribed different antipsychotic medications, in sufficient doses and for an appropriate duration of time, on both an inpatient and outpatient basis. Despite his compliance, he did not show a significant improvement in his psychotic symptoms, especially his paranoid delusions. A regimen of risperidone was prescribed for his psychosis and was titrated to 4 mg daily. The patient demonstrated amelioration of his psychotic symptoms and he has been free of psychosis for 2 years.

The mechanism by which epilepsy may be associated with the psychotic episodes is not well known; it is likely that structural brain abnormalities cause both epilepsy and psychosis. 3 Several studies reported that seizures modify the presentation of the psychosis; psychosis complicates epilepsy when seizures are frequent. 3

Researchers reported that about 50% of epileptic patients with psychosis could be diagnosed with schizophrenia. 8 Psychosis of epilepsy is distinguishable from schizophrenia by the lack of negative symptoms of schizophrenia and better premorbid personality. 8

Treatment of psychosis of epilepsy requires more careful pharmacological treatment, considering the ability of the antipsychotic medications to provoke seizures. 10

In our case, risperidone was associated with a clinically significant improvement of the psychotic symptoms without exacerbation of the seizure activity.