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Published Online: October 1968

The Effects of Lithium Salts on Brain Activity in the Cat

ERNEST S. BARRATT, DANIEL L. CRESON, and GLENN RUSSELLAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 125, Number 4

https://doi.org/10.1176/ajp.125.4.530

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Abstract

Two sets of experiments were conducted to study the effects of lithium on the gross electrical activity of the cat brain. The first series, designed to study acute effects by means of recording evoked potentials using encephale isolé cats, suggests that the orbito-frontal cortex is a primary brain locus for the immediate effects of lithium. The second series of experiments, designed to study chronic effects, suggests that lithium produces widespread EEG slowing after it has been administered for seven days; marked behavioral changes were also observed in these cats following the seven-day course of lithium administration.

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Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 125 • Number 4 • October 1968

Pages: 530 - 536

PubMed: 5711816

History

Published in print: October 1968

Published online: 1 April 2006

Authors

Affiliations

ERNEST S. BARRATT

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DANIEL L. CRESON

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GLENN RUSSELL

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Research professor, department of neurology and psychiatry, University of Texas Medical Branch, Galveston, Tex. 77550

University of Texas Medical Branch, Galveston, Tex. 77550

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The Effects of Lithium Salts on Brain Activity in the Cat

Abstract

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