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Published Online: August 1957

CLINICAL EVALUATION OF PACATAL

Publication: American Journal of Psychiatry

Abstract

1. Pacatal is capable of eliciting therapeutic responses in chronically psychotic patients.
2. It is most efficacious for those aspects of behavior which are related to increased anxiety and least efficacious for judgment, insight, orientation, memory and affect.
3. The clinically significant side-effects are those related to the atropine-like action of Pacatal. Untreated eye complications, following prolonged administration of Pacatal, may lead to ulceration of the corneal epithelium.
4. It is recommended that any prolonged ocular disturbance as a result of Pacatal medication be treated with Neostigmine.
5. All the side-effects produced by Pacatal can be obliterated by symptomatic medication, lowering of daily dosage or discontinuation of the medication.
6. The results obtained with Pacatal are encouraging and warrant further investigation upon a prognostically better group of psychotic patients.

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Go to American Journal of Psychiatry
Go to American Journal of Psychiatry
American Journal of Psychiatry
Pages: 143 - 146
PubMed: 13444479

History

Published in print: August 1957
Published online: 1 April 2006

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PAUL E. FELDMAN
Director of Research and Education, Topeka State Hospital, Topeka, Kansas.

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