14. EXPERIMENTAL HISTOPATHOLOGICAL RESEARCHES ON INSULIN SHOCK

F. AccorneroAuthors Info & Affiliations

Publication: American Journal of Psychiatry

Volume 94, Number 6S

https://doi.org/10.1176/ajp.94.6S.130

Get Access

Abstract

In dogs which are given a few shocks close together and which die in insulin coma there are observed very acute, diffuse, edematous alterations which are very probably reversible. Butthere are observed also in many neurons (cells and fibers) very severe irreversible changes with wide distribution. Moreover, at certain spots there are more or less advanced areas of necrotic destruction of the nervous elements, with productive reaction on the part of the vessels.

In dogs which are given many shocks close together and which do not die in insulin coma there are noted on the whole analogous manifestations except that the acute edematous changes are found to be less diffuse. But the areas of cellular rarefaction are still encountered. They often involve different layers of the cortex and are not infrequently sharply bounded by less damaged areas of cortex, in which the architecture of the parts is recognizable.

Such sharp demarcation suggests that these areas are related to circulatory disturbances. This relation is very important from the physiopathogenetic point of view so that further study will be necessary and is now being contemplated.

We may conclude from these researches that in dogs the therapy with repeated insulin coma not only brings about the destruction of a certain number of cortical neurons scattered here and there (presumably the less resistant neurons higher in the evolutionary scale), but also causes the production of patches in which along side of the destruction of specifically nervous tissue, there is a lively proliferative reaction on the part of both neuroglial tissue and blood vessels.

Get full access to this content

View all available purchase options and get full access to this content.

Get Access

Information & Authors

Information

Published In

American Journal of Psychiatry

Volume 94 • Number 6S • May 1938

Pages: 130 - 133

History

Published in print: May 1938

Published online: 1 April 2006

Authors

Details

F. Accornero

Rome

View all articles by this author

Metrics & Citations

Metrics

Citations

Export Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.

For more information or tips please see 'Downloading to a citation manager' in the Help menu.

Format	RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks
Direct importt
Citation style
Style

Copy to clipboard
Tips for downloading citations

View Options

Login options

Already a subscriber? Access your subscription through your login credentials or your institution for full access to this article.

Personal login Institutional Login Open Athens login

Purchase Options

Purchase this article to access the full text.

PPV Articles - American Journal of Psychiatry

Not a subscriber?

Subscribe Now / Learn More

PsychiatryOnline subscription options offer access to the DSM-5-TR^® library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

14. EXPERIMENTAL HISTOPATHOLOGICAL RESEARCHES ON INSULIN SHOCK

Abstract

Get full access to this content