Fertility of Patients With Schizophrenia, Their Siblings, and the General Population: A Cohort Study From 1950 to 1959 in Finland

The study population consisted of all individuals born in Finland from 1950 to 1959. Persons born outside Finland or of unknown birthplace were excluded. Individuals who had had at least one hospitalization because of schizophrenia between Jan. 1, 1969, and Jan. 1, 1992, were identified from the National Hospital Discharge Register. Schizophrenia was defined as a 295 diagnosis code according to ICD-8 and ICD-9, which includes schizophrenia, schizophreniform disorder, and schizoaffective disorder. Information on their siblings was obtained from the Population Register Center and was linked by using the personal identification numbers, which code the date of birth and sex and are unique for each person.

The year of birth and sex of all offspring of the study population until year 2000 were obtained from the Population Register Center. Thus, for all individuals of the study population we had the following data: year of birth, sex, year of birth and sex of all offspring, and a categorical variable indicating whether the individual was a person with schizophrenia, a sibling of a person with schizophrenia, or neither.

The following response variables were used: age when the first child was born, number of offspring, number of offspring for each person with at least one child, an indicator variable for the presence of at least one offspring, and the proportion of males among the offspring. We used a linear regression model for age at the birth of the first child, a Poisson regression model for number of children, and a logistic regression model for proportions (26). Categorical birth year (1950–1959) and study group (schizophrenic, sibling, or general population) were used as explanatory variables. Separate models were fitted for male and female subjects. The significance of the explanatory variables was tested by using likelihood ratio statistics. The significance of differences between subgroups (schizophrenic, sibling, and general population) was tested by using Wald-type tests. All calculations were carried out by means of the S-PLUS program (27).

We gathered information on the number of offspring of all 870,093 individuals born in Finland from 1950 to 1959 (Table 1). Of the total population, 1.3% had schizophrenia, and 2.8% were siblings of patients with schizophrenia. Although the observed prevalence is relatively high, it is in line with earlier Finnish findings, such as the 1.3% in the Mini Finland Health Survey (28) and 2.0% in a twin study (14).

As shown in Table 2, the proportion of individuals with at least one child was clearly lowest among the patients with schizophrenia of both sexes (women: χ²=3263.22, df=1, p<0.001; men: χ²=7264.72, df=1, p<0.001). There was no significant difference between the general population and the female siblings of schizophrenic patients (χ²=1.03, df=1, p=0.31), but among males the proportion of individuals with at least one child was lower among siblings (χ²=251.13, df=1, p<0.001). The number of offspring was highest among female siblings of schizophrenic patients, although the absolute difference from the general population was only 0.03 (χ²=23.29, df=1, p<0.001); for male siblings the number of offspring was 0.05 lower (χ²=52.69, df=1, p<0.001). When the numbers of offspring were compared only among subjects with at least one child, the siblings of schizophrenic patients had significantly higher numbers, both for women (χ²=29.66, df=1, p<0.001) and for men (χ²=31.78, df=1, p<0.001). There were no significant differences in the proportion of male offspring among the three groups (Table 2).

The patients with schizophrenia had, on average, one child less than individuals in the general population, as found in several earlier studies (2, 5–10). Among female siblings of patients with schizophrenia, the number of offspring was slightly higher than among women in the general population, while male siblings had fewer offspring than men in the general population. At first sight, our results may seem to provide weak evidence for the hypothesis that the lower fertility of patients with schizophrenia is compensated for by more children among their relatives. Three earlier studies (6, 8, 24), although based on much smaller study groups and comparing fertility among parents, not among siblings, provided some support for this hypothesis. However, a simple calculation based on the predicted number of offspring among women in our study shows that this compensation is insufficient. Assume that the cumulative lifetime incidence of schizophrenia is 1% and that every family has three offspring, making 2% of the population siblings of patients with schizophrenia. Combine these assumptions with predictions from the data in Table 2 on the numbers of children for all female subjects. The result is that in the next generation, 2.1% of the offspring are produced by siblings of patients with schizophrenia; this calculation is based on the formula (0.02×1.91)/([0.97×1.84]+[0.02×1.91]+[0.01×0.83]). The patients with schizophrenia would produce 0.5% of the offspring: (0.01×0.83)/([0.97×1.84]+[0.02×1.91]+[0.01×0.83]). This means that the proportion of genes inherited from these families would be lower in the new generation than in the previous one.

A recent report (29) suggesting that the risk of schizophrenia is associated with increasing paternal age lends some support to the hypothesis that schizophrenia may be partly due to de novo mutation of the paternal germ cells. Our study findings are not in conflict with this view: new mutations could explain the persistence of schizophrenia despite lower fertility of schizophrenic individuals.

On the other hand, it may be that evolutionary selection mechanisms working against schizophrenia-related genes are related to environmental factors. That is, it is possible that the genes provided some physiological advantage in the past but with a changing environment no longer do so. The observed decline in the incidence of schizophrenia in Finland between 1954 and 1965 (30) could have been caused by changes in these factors. For example, our study on regional differences in the incidence of schizophrenia in Finland (31) showed that areas that had higher neonatal mortality rates used to have higher incidences of schizophrenia. If this was caused by greater robustness associated with the schizophrenia genotype, leading to increased survival, as has been suggested (32), this advantage may have disappeared when factors that caused the higher neonatal mortality rate disappeared.

It is also possible that fertility among patients with schizophrenia spectrum disorder or among their relatives is high, thereby explaining the persistence of genes predisposing to schizophrenia. At least, the reproductive fitness among persons having schizotypal personality disorder is not lower than average (33).

Finally, it may be that low fertility is a recent phenomenon related to, for example, culturally delayed marriage (17). Consistent with this view are findings from a British case-control study from London (34), which showed that the marital rate and fertility of patients with schizophrenia who were white British or of Caribbean origin were lower than those of comparison subjects, but no such difference was observed for patients of Asian origin. This means that our results may not be generalizable to other populations or even to other Finnish birth cohorts, as cultural and economical factors probably are the most important determinants of the number of offspring among humans.

The National Hospital Discharge Register, used in this study, has been found to be a reliable and accurate tool in epidemiological research (35). The reliability of diagnoses of schizophrenia in the Hospital Discharge Register has been assessed in several studies (14, 36). These studies show that Finnish psychiatrists tend to apply a narrow definition of schizophrenia in their clinical practice, with more of a tendency toward false negative than false positive diagnoses. Therefore, mild cases of schizophrenia are not included. The main limitation of our study is that we dealt only with the fertility of one generation. From an evolutionary perspective, it would be important to study fertility in two or more successive generations. It should be noted that the findings for the female subjects are more meaningful, because there is always more uncertainty about paternity. Another aspect is that all of the female subjects were followed up close to the end of their reproductive life (at least age 41), thus providing more complete information on overall fertility.

These findings indicate that the genetic basis of schizophrenia is still unresolved, and it seems that no simple evolutionary mechanism can explain the persistence of genes connected to schizophrenia in the population.

Received June 12, 2002; revision received Sept. 12, 2002; accepted Sept. 19, 2002. From the Kansanterveyslaitos, National Public Health Institute. Address reprint requests to Dr. Haukka, Kansanterveyslaitos, National Public Health Institute, Mannerheimintie 160, FIN-00300 Helsinki, Finland; [email protected] (e-mail).