“Selfish Spermatogonial Selection”: A Novel Mechanism for the Association Between Advanced Paternal Age and Neurodevelopmental Disorders
Abstract
Key Differences Between Male and Female Gamete Production
Advanced Paternal Age and Mental Disorders
Paternal Age Effect Mutations and Selfish Selection in the Testis
Genetic Architecture of Neurocognitive Disorders and Selfish Selection
Weak Selfish Mutations and Common Diseases
Does the Selfish Selection Hypothesis Have Explanatory Power?
Clues Linking Paternal Age, Cancer, and Neurodevelopmental Disorders
Clues Related to Minor Physical Anomalies, the Cell Cycle, and Synaptic Plasticity
An Integrative Model and Testable Hypotheses
Conclusions
Acknowledgments
References
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