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Cocaine and methamphetamine are psychostimulants that activate the central nervous system and produce powerful reinforcing effects (e.g., euphoria, elevated mood, and high) that contribute to their high addiction liability. Although significant advances were made in uncovering the neurobiological mechanisms underlying stimulant addiction, this new knowledge has yet to translate into effective pharmacotherapies for stimulant use disorder (Forray and Sofuoglu 2014). However, several effective behavioral interventions are available for the treatment of stimulant use disorder (Dutra et al. 2008). The pharmacological and behavioral treatment research has focused mainly on cocaine use disorder, and it is generally assumed that findings from these studies may also be generalized to the treatment of methamphetamine use disorder.
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