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Excerpt

Psychosis is a broad term, usually referring to any psychiatric disorder in which there is a loss of reality testing, which is generally reflected by the presence of delusions, hallucinations, and/or severe thought disorder and may entail serious behavioral disturbances. In individuals with traumatic brain injury (TBI), reports of psychosis have included cases that would meet criteria for delirium, schizophrenia, schizophreniform disorder, delusional disorder, bipolar disorder, or major depression. The greatest interest, however, has been generated by the association between TBI and schizophrenia-like psychosis (Krafft-Ebing 1868), and this is the focus of this chapter. The most important question is whether TBI predisposes an individual to schizophrenia or schizophrenia-like psychosis. If this association can be unequivocally established, a number of other issues become relevant, such as the prevalence of schizophrenia-like psychosis following TBI, its clinical features, risk factors, and prognosis. An important corollary is whether the study of schizophrenia-like psychosis following TBI can advance the understanding of the etiopathogenesis of schizophrenia.

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