Chapter 3.Genetics and Genomics
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Excerpt
Genetics and genomics are among the most important tools in modern psychiatric research. Spurred by the completion of the human genome sequence in 2001, the number of psychiatric genetic studies has increased dramatically in the last two decades (Lander et al. 2001; Venter et al. 2001). In this chapter, we cover the basic methodologies and concepts and define key terms currently used in psychiatric genetics and genomics. Figure 3–1 illustrates the genetic methods available in psychiatric research today. Our goal is to facilitate interpretation by physicians and scientists in the field of psychopharmacology of the avalanche of genetic and genomic data accumulating in the human neuropsychiatric literature. Throughout this chapter, terms in common use in the genetics and genomics literature are italicized on first use and are defined.
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