Chapter 4.Psychoneuroendocrinology
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Excerpt
The associations between hormonal changes and psychiatric disorders have long been recognized, but only in recent decades have the underlying mechanisms begun to be understood. A renewed interest in the associations linking stressful early life events, hypothalamic-pituitary-adrenal (HPA) axis dysregulation, inflammatory processes, and potential vulnerability to depression, psychosis, and posttraumatic stress disorder (PTSD) has prompted a resurgence of research in this field. Although the association between reproductive hormone changes and psychiatric disorders has been less well studied, there is likewise a growing clinical recognition of the burden of postpartum psychopathology and a new impetus for research progress in this area. A full account of how each endocrine system influences neurobehavioral function is beyond the scope of a single chapter; we focus here on summarizing the most firmly established findings from classic literature in the field, and on providing an overview of some recent promising research findings.
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