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Chapter 11.Sertraline

Edited by:
https://doi.org/10.1176/appi.books.9781615371624.as11

Sections

History and Discovery | Structure–Activity Relations | Pharmacological Profile | Pharmacokinetics and Disposition | Mechanism of Action | Indications and Efficacy | Side Effects and Toxicology | Drug–Drug Interactions | Conclusion | References

Excerpt

Research has implicated dysregulation of serotonin (5-hydroxytryptamine [5-HT]) in mood and anxiety disorders. Researchers therefore identified compounds that are selective in blocking neurotransmitter reuptake and yet have little agonist and antagonist activity at receptors thought to be associated with adverse effects. Sertraline, a naphthylamino compound that is structurally different from monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs), is a member of this class of drugs (Guthrie 1991; Heym and Koe 1988).

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