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Chapter 17.Mirtazapine

Edited by:
https://doi.org/10.1176/appi.books.9781615371624.as17

Sections

History and Discovery | Structure–Activity Relations | Pharmacological Profile | Pharmacokinetics and Disposition | Indications and Efficacy | Side Effects and Toxicology | Drug–Drug Interactions | Conclusion | References

Excerpt

Mirtazapine, originally known as ORG 3770, was first synthesized in the Netherlands by the Department of Medicinal Chemistry of NV Organon (Kaspersen et al. 1989). First approved for use in major depressive disorder in the Netherlands in 1994, mirtazapine was introduced in the United States in 1996.

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