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Published Online: 24 March 2015

Anxiety in Huntington’s Disease

Maria Dale, D.Clin.Psy., and Erik van Duijn, M.D., Ph.D.Authors Info & Affiliations

Publication: The Journal of Neuropsychiatry and Clinical Neurosciences

Volume 27, Number 4

https://doi.org/10.1176/appi.neuropsych.14100265

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Abstract

Anxiety is common in Huntington’s disease (HD), though it has been under-researched. The authors conducted a systematic review of anxiety in HD. The prevalence of anxiety in manifest HD ranged from 13% to 71%. No significant difference in anxiety between manifest and premanifest HD carriers was revealed. Anxiety appears to be associated with depression, suicide, irritability, quality of life (QoL), pain, illness beliefs, and coping styles but does not seem to be linked with measures of disease progression. From the few pilot studies available, interventions that show promise include olanzapine and psychosocial approaches. Improved assessment, more exploration of the nature of anxiety in HD, and evaluation of anxiety interventions are required.

Huntington’s disease (HD) is a genetic neurodegenerative disease characterized by motor disturbance, cognitive decline, and psychiatric symptoms. HD is caused by an expansion of cytosine-adenine-guanine (CAG) repeats in the Htt gene on the short arm of chromosome 4, resulting in production of the mutant protein huntingtin. The exact pathophysiological processes that occur in HD are not yet fully understood, although different mechanisms have been suggested.¹ The onset of the disease usually occurs in midadulthood, with considerable variation in clinical presentation. The disease is autosomal dominant, which means that those who carry the gene present a 50% risk of passing the disease to any of their children. The duration of the disease varies but is, on average, 20 years from the onset of motor signs to death.² As yet, no cure has been identified for HD, although treatments to manage different symptoms may help reduce distress and improve QoL.

So far, the clinical diagnosis of HD is dependent on the motor signs of the disease, involving problems with voluntary and involuntary movements. However, cognitive and psychiatric symptoms may be present many years before the onset of motor problems.^3–5 The psychiatric component of the disease can involve a number of different complaints including depression, irritability, anxiety, apathy, obsessive-compulsive behaviors (OCBs), and psychosis.^6,7 Although motor and cognitive symptoms worsen with time, psychiatric symptoms appear to have a more variable course,⁸ with the exception of apathy, which is more prevalent in advanced disease stages.

A systematic review of psychopathology in HD identified that the prevalence of anxiety among manifest HD participants was between 34% and 61%, depending on the disease stage and the measure used.⁷ Although anxiety symptoms are commonly reported in HD, this topic has received limited attention in the literature, with the exception of OCBs, which have been reported on more frequently.⁹ However, it is questionable whether OCBs in HD may be construed as an anxiety condition, as there is evidence that they may be more closely associated with the cognitive changes in HD, particularly executive dysfunction.¹⁰

Because there is a lack of information about anxiety in HD, we systematically reviewed the literature on the epidemiology and phenomenology of anxiety in HD and identified areas for future study.

Methods

We carried out data searches using PsycINFO and MEDLINE to identify published articles from 1994–2014. The rationale for our exclusion of articles written before 1994 was due to predictive genetic testing only becoming available after the discovery of the HD gene in 1993. Searches were restricted to human studies that were written in English. The following search strings were used in February 2014: “Huntington*” combined with “anxiety*,” “psychiatric,” and “psychological.” The term “depression” was also combined with “Huntington*,” as we were aware that some studies of anxiety in HD are embedded within broader research of depression in HD and that some studies using measures of psychopathology, developed specifically for use within an HD population, combined factors for anxiety and depression.

From the database searches, we retrieved a total of 209 articles from MEDLINE and 230 from PsycINFO. An additional eight articles were identified from reference lists and consultation with researchers in the field. Duplicates were removed, resulting in 297 articles. We then conducted a manual search of titles and abstracts and excluded the following: case studies, conference abstracts, qualitative studies or studies with no standardized measure of anxiety, reviews, dissertation abstracts, juvenile HD studies, and studies not including verified HD expansion carriers (e.g., involving only at-risk or caregivers of HD). We also excluded articles that were confined only to obsessive-compulsive disorder (OCD) because it could be argued that these symptoms are more closely related to the cognitive symptoms of HD, rather than anxiety.

Following this, a total of 70 studies warranted manual full-text searches to assess eligibility. Reasons for article exclusion at this stage were that they did not include a standardized measure of anxiety (N=20), they were review articles (N=4), or the sample included participants with disorders other than HD (N=1). The total number of studies finally included was 45. See Figure 1 for a summary of the review process.

FIGURE 1. Flowchart Illustrating the Number of Articles Excluded at Each Stage of Eligibility Screening

Results

Using the eligibility criteria, we found the following studies: 16 articles reporting on prevalence studies (Table 1), 13 articles describing group comparisons (Table 2), 28 articles reporting correlates and predictors (Table 4), and five articles describing interventions (Table 5). Sixteen studies fell into more than one group. None of the studies examined anxiety as the primary theme of the study.

TABLE 1. Prevalence of Anxiety in HD Expansion Carriers

Study	No. of Participants	Measure	Disease Duration (years), Mean (SD) [range]	Disease Stage	Country	Prevalence
Manifest HD
Murgod et al. (2001)¹²	26	UHDRS	5.5 (3.9) [1–20]	1–5	India	61.5% (point prevalence)
Paulsen et al. (2005)⁸	2,835	UHDRS	7.6 (6.0)	1–5	U.S.	41% (point prevalence)
Craufurd et al. (2001)⁶	134	PBA-HD	9±5 [1–23]	1–5	UK	37% (point prevalence)
Thompson et al. (2012)¹⁵	111	PBA-HD	5.5 (4.7)	1–5 at baseline	UK	71% (cumulative prevalence at 3 years)
Kulisevsky et al. (2001)¹⁷	29	NPI	5.6±1.6	Not given	Spain/U.S.	34% (point prevalence)
Paulsen et al. (2001)¹⁸	52	NPI	4.7 (4.4) [1–20]	Not given	U.S.	51.9% (point prevalence)
Kristjanson et al. (2006)²⁰	46	HADS	7.8 (4.8)	Not given	Australia	41% (point prevalence)
Arran et al. (2014)²¹	165	HADS	Not given	Not given	UK	48% point prevalence
Leroi et al. (2002)²⁶	21	SCID	12 (6.6)	Not given	U.S.	24% (lifetime prevalence)
Vassos et al. (2008)²⁴	72	SCID	5.62 (5.7)	Not given	Greece	12.5%, (point prevalence)
Vassos et al. (2008)²⁴	72	SCID	5.62 (5.7)	Not given	Greece	16.7% (lifetime prevalence)
van Duijn et al. (2008)²⁵	85	CIDI	Not given	Not given	Netherlands	16.5% (12-month prevalence)
Premanifest HD
Berrios et al. (2001)^28,^a	26	CIDI	N/A	N/A	UK	11.5% (point prevalence)
Berrios et al. (2001)^28,^a	26	STAI	N/A	N/A	UK	11.5% (point prevalence)
Berrios et al. (2002)^29,^a	32	CIDI	N/A	N/A	UK	0% (point prevalence)
Berrios et al. (2002)^29,^a	32	STAI	N/A	N/A	UK	0% (point prevalence)
Shiwach and Norbury (1994) ^31,^a	20	PSE	N/A	N/A	UK	0% (point prevalence)
Julien et al. (2007)^30,^a	89	CIDI	N/A	N/A	UK	15% (point prevalence)
Julien et al. (2007)^30,^a	89	CIDI	N/A	N/A	UK	17% (lifetime)
van Duijn et al. (2008)^25,^b	55	CIDI	N/A	Not given	Netherlands	14.5% (12-month prevalence)
All HD mutation carriers
Reedeker et al. (2012)²⁷	142 at baseline,	CIDI	Not given	1–2	Netherlands	17% (2-year cumulative prevalence)
Reedeker et al. (2012)²⁷	106 at follow-up	CIDI	Not given	1–2	Netherlands	17% (2-year cumulative prevalence)

Participants blinded to genetic status at time of anxiety assessment.

Participants aware of genetic status at the time of anxiety assessment.

TABLE 2. Group Comparisons of Anxiety in HD Expansion Carriers and Noncarriers

Group Comparisons	Noncarriers (N)	Premanifest HD (N)	Manifest HD (N)	Measure of Anxiety Used	Outcome
Manifest versus premanifest
Soliveri et al. (2002)^23,s	—	17	40	HAM-A	Manifest>premanifest
Marshall (2007)^4,^b	—	49	34	SCL-90	NS
van Duijn et al. (2008)^25,^a	—	55	85	CIDI	NS
Manifest versus noncarrier^,^c
Soliveri et al. (2002)^23,^a	28	—	40	HAM-A	Manifest>noncarrier
van Duijn et al. (2008)^25,^a	56	—	85	CIDI	NS
Premanifest versus noncarrier
Shiwach and Norbury (1994)^31,^d	33	20	—	PSE	NS
Rosenberg et al. (1995)^55,^d	19	14	—	SCL-90 R	NS
Decruyenaere et al. (1995)^56,^d	Male=12	Male=13	—	STAI	Male carriers significantly less anxious than noncarriers, no difference for females. No analysis for total sample of males and females.
Decruyenaere et al. (1995)^56,^d	Female=23	Female=12	—	STAI
Decruyenaere et al. (1996)^22,^c	31	22	—	STAI	NS at pretest and post-test
Decruyenaere et al. (1999)^44,^c	40	29	—	STAI	NS at pretest and 1 year posttest
Soliveri et al. (2002)^23,^a	28	17	—	HAM-A	NS
Berrios et al. (2002)^29,^d	66	32	—	CIDI	NS
Witjes-Ane et al. (2002)^14,^c	88 at baseline,	45	—	UHDRS	NS at pretest and 18 months posttest
Witjes-Ane et al. (2002)^14,^c	78 at 18 months	35	—	UHDRS	NS at pretest and 18 months posttest
Decruyenaere et al. (2003)^45,^c	33	24	—	STAI	NS pretest and 5 years posttest
Duff et al. (2007)^3,^a	92	589	—	SCL-90 R	Premanifest>noncarrier
Marshall et al. (2007)^4,^b	171	49	—	SCL-90 R	Premanifest>noncarrier
Julien et al. (2007)^30,^d	115	89	—	CIDI	NS
van Duijn et al. (2008)^25,^a	56	55	—	CIDI	NS

Participants aware of genetic status at time of anxiety assessment.

Participants included a mix of those who were or were not aware of their genetic status.

Anxiety assessments undertaken before and after genetic testing.

Participants blinded to genetic status at time of anxiety assessment.

TABLE 3. Prevalence of Individual Anxiety Disorders Among HD Expansion Carriers

Study	Participants (N)	Agoraphobia (%)	GAD (%)	Panic Disorder (%)	Simple Phobia (%)	Social Phobia (%)
Berrios et al. (2001)^28,^a	Pre-HD (26)	—	3.8	7.7	—	—
Julien et al. (2007)^30,^a	Pre-HD (89)	6	9	6	7	2
van Duijn et al. (2008)^25,^b	Pre-HD (55)	1.8	5.5	3.6	—	5.5
van Duijn et al. (2008)^25,^b	HD (85)	1.2	4.7	4.7	—	5.9
Reedeker et al. (2010)²⁷	All HD expansion carriers (142 at baseline, 106 at follow-up)	2.8	5.7	5.7	—	7.5

Participants blinded to genetic status at time of anxiety assessment.

Participants aware of genetic status at time of anxiety assessment.

TABLE 4. Studies of Correlates and Predictors

Study	No. of Participants	Measure of Anxiety	Outcome
Jankovic et al. (1995)⁴⁶	36 HD	UHDRS	Assessed impact of genetic testing and found no change in anxiety before and after testing
Decruyenaere et al. (1996)²²	22 pre-HD	STAI	No change in anxiety before and 1 year after genetic testing
Levy et al. (1998)³⁷	34 HD	NPI	Apathy did not correlate with anxiety. A relationship between anxiety and depression was found
Decruyenaere et al. (1999)⁴⁴	29 HD	STAI	No change in anxiety before and 1 year after genetic testing
Craufurd et al. (2001)⁶	134 HD	PBA-HD	Anxiety loaded on to depression, but not irritability or apathy. No relationship was found between anxiety and duration of illness
Paulsen et al. (2001)¹⁸	52 HD	NPI	Gender, age, apathy, illness duration, chorea severity, dementia severity, euphoria, disinhibition, and delusions did not correlate with anxiety. Agitation, irritability, and dysphoria did correlate with anxiety
Witjes-Ane et al. (2002)¹⁴	35 pre-HD	UHDRS	Gender and age were not associated with anxiety. No change in anxiety 18 months after testing
Decruyenaere et al. (2003)⁴⁵	24 pre-HD	STAI	There was a significant reduction in trait anxiety 5 years after predictive testing and state anxiety 1 year and 5 years after testing
Marshall et al. (2007)⁴	49 pre-HD	SCL-90 R	Premanifest HD carriers had more motor abnormalities. Although not reaching manifest HD, they had more anxiety than premotor symptomatic carriers with no or minor nonspecific motor abnormalities, but this finding did not reach significance
Paulsen et al. (2005)⁸	2,835 HD	UHDRS	A higher level of anxiety was found in stage 2 disease than in other stages; after stage 2, a progressive decrease in anxiety was reported
Julien et al. (2007)³⁰	89 pre-HD	CIDI	Presence of anxiety disorders was not related to proximity to onset of manifest HD
Kingma et al. (2008)³⁸	152 all carriers	PBA-HD	Anxiety loaded onto depression factor, not irritability or apathy
Zappacosta et al. (2008)³²	29 HD	HAM-A	Anxiety correlated with depression but not with CAG repeats, motor ability, cognitive functioning, and duration of illness
Leroi et al. (2002)²⁶	21 HD	SCID	Anxiety was not associated with gender
Vassos et al. (2008)²⁴	72 HD	SCID	CAG repeats were not associated with anxiety
McCabe et al. (2009)³⁴	48 HD	POMS-SF	Anxiety-tension made a significant contribution to QoL
Marder et al. (2010)³⁵	960 HD	UHDRS	Anxiety loaded onto depression factor. Severity on the depression/anxiety factor of the UHDRS influenced the rate of decline on the Independence Scale
Litvan et al. (1998)³³	29 HD	NPI	Positive relationship between agitation/irritability and anxiety No relationship was found between the degree of chorea and anxiety
Thompson et al. (2012)¹⁵	86 HD	PBA-HD	Did not find an increase in anxiety across stages of disease progression
Wetzel et al. (2011)⁴¹	1941 HD	UHDRS	Depression/anxiety was found to significantly predict suicidal ideation and the top most 25% most severe suicidal ideation among the sample
Soliveri et al. (2002)²³	40 HD	HAM-A	Anxiety was associated with depression but not with CAG repeat length, motor ability, cognitive functioning, or disease duration
Rickards et al. (2011)³⁹	1803 HD	UHDRS	Support for a cluster of symptoms involving anxiety and depression was found in this factor analysis study
Rickards et al. (2011)⁴⁰	768 HD	HAM-D	Anxiety item on the HAM-D was not good at discriminating between HD patients who were or were not experiencing depressed mood
Nimmagadda et al. (2011)³⁶	30 HD	IDA, STAI	State and trait anxiety were associated with inward and outward irritability; state and trait anxiety correlated with depression
Berrios et al. (2001)²⁸	26 pre-HD	CIDI, STAI	No relationship between anxiety and CAG repeat length
Hubers et al. (2013)⁴³	2106 HD	UHDRS	Anxiety was independently associated with suicidal ideation at baseline, but during a 4-year period it was not predictive of suicidal ideation
Fiedorowicz et al. (2011)⁴²	735 pre-HD	PSS	Anxiety was not found to be an independent risk factor for suicidal behavior, defined as suicide or attempted suicide, across a mean of 3.7 years’ prospective follow-up
Arran et al. (2014)²¹	165 HD	HADS	Anxiety was associated with pain, high number of symptoms, less strong belief in treatment control, and stronger belief in fluctuation of illness. Coping strategies associated with high anxiety were low acceptance, venting, self-blame, and behavioral disengagement

TABLE 5. Interventional Studies

Study	No. of Participants	Intervention	Methodology	Measure of Anxiety Used	Outcome
Murman et al. (1997)⁵⁷	10	Ketamine at 0.10, 0.40, and 0.60 mg/kg/hr	Double-blind, placebo-controlled, 1-day testing of increasing doses	BPRS and SRS	Nonsignificant
Squitieri et al. (2001)⁴⁸	10	Olanzapine at 5 mg dose orally once per day	Open pilot, no control group, no blinding; 6-month intervention	UHDRS	Significant improvement at p=0.016
Lundin et al. (2010)⁵⁸	28 treatment, 30 control, All manifest HD	Pridopidine at 50 mg/day	Randomized, double-blind, placebo-controlled 4-week trial	HADS	Nonsignificant trend for improvement
A’Campo et al. (2012)⁴⁷	29 HD with caregivers 12 pre-HD with partners	PEP-HD	Pilot study, no control group	HADS	Significant improvement at p=0.05 for manifest HD Nonsignificant for premanifest HD
Piira et al. (2013)⁴⁹	37	Intensive multidisciplinary program	Pilot study, no control group	HADS	Significant improvement at p=0.001

Prevalence and Group Comparison Studies

Prevalence studies are presented in Table 1. The prevalence of anxiety ranged from 13% to 71% in manifest HD participants and from 0% to 15% in premanifest carriers. Of these studies, 11 examined prevalence in manifest HD participants, five involved premanifest participants, and one study involved both manifest and premanifest carriers. Studies that compared the presence of anxiety in HD expansion carriers and verified noncarriers are presented in Table 2.

HD-specific measures.

HD-specific assessments used to measure prevalence were the United Huntington’s Disease Rating Scale (UHDRS)¹¹ and the Problem Behaviors Assessment for Huntington’s Disease (PBA-HD).⁶ The UHDRS has one item that measures frequency and severity of anxiety on a 5-point scale. The PBA-HD has one item that relates to anxiety, with the longer version also having an item on tension.

Two studies used the UHDRS among manifest HD participants and reported prevalence varying from 41% (N=2,835)⁸ to 62% (N=26).¹² One factor that may account for the differences in these rates is that the former study used a cutoff score of greater than 3 when frequency was multiplied by severity on the UHDRS, whereas the latter study did not indicate a precise cutoff score; rather, the authors stated that there were “behavioural disturbances of some degree.” Also, the first study involved a U.S. sample,⁸ whereas the second study was conducted in India.¹² Both studies included participants from across all five disease stages,¹³ although the U.S. study included a large majority (85% of the sample) with disease stages 1–3. This large-scale U.S. study was the only article identified that examined anxiety by disease stage, defined by a Total Functioning Capacity score of the UHDRS.¹³ A higher level of anxiety was found in stage 2 than in other stages of the disease; after stage 2, there was a progressive decrease in anxiety.

The UHDRS was used in only one study that examined HD carriers not yet manifest for the disease.¹⁴ Anxiety in a premanifest group was compared with a control group of noncarriers, and no differences in anxiety were found between the groups before predictive genetic testing or 18 months after test results were received. The PBA-HD was used to examine the prevalence of anxiety in HD in two studies. A cross-sectional study using the PBA-HD involving 134 UK HD participants showed a point prevalence of 37%,⁶ whereas a longitudinal study using the PBA-HD reported a prevalence of 71% in 111 UK HD participants across 3 years.¹⁵ In both studies, participants were said to experience anxiety if they scored ≥2 on the severity scale of the PBA-HD. No studies were identified that used this instrument to assess anxiety among premanifest carriers or noncarriers.

General symptomatology measures of anxiety.

Assessments of general symptomatology measures of anxiety were used for four studies involving manifest carriers. Two studies used the Neuropsychiatric Inventory (NPI),¹⁶ which has one domain that inquires about anxiety, with severity and frequency of symptoms rated by an informed caregiver. One study using the NPI obtained a prevalence rate of 51.9% (N=52),¹⁸ where participants who received a score of ≥1 on the NPI were viewed as endorsing anxiety. The other NPI study stated that 34% of 29 HD participants demonstrated “frequency of changes” in anxiety.¹⁷

The Hospital Anxiety and Depression Scale (HADS),¹⁹ which has seven questions relating to anxiety symptoms, each scored on a 4-point scale, was used in two studies. In one of these studies, a cutoff value of ≥8 was used to identify anxiety cases, obtaining a prevalence of 48%²¹; the other study did not provide a figure for a cutoff point, instead stating that 41% of their sample reported moderate to severe anxiety.²⁰

Two studies used general symptomatology measures, the Symptom Checklist (SCL)-90 and Hamilton Anxiety Scale (HAM-A), to compare anxiety in manifest HD with premanifest HD^4,23; no difference was found in mean scores between the groups. These two studies also compared anxiety levels among manifest HD patients with noncarriers and found that manifest HD participants reported more anxiety symptomology than noncarriers.

Eight studies examined differences in mean anxiety scores between premanifest HD carriers and noncarriers using general symptomatology measures. The majority of these studies found no significant difference, although two studies with the largest sample sizes found that premanifest HD carriers reported more anxiety^3,4 (see Table 2). Three studies examined premanifest carriers and noncarriers longitudinally to assess anxiety pre- and postpredictive testing and found no difference between the premanifest group and noncarriers before or after testing up to 5 years after disclosure of their genetic status.

Diagnostic measures.

Three studies used a structured diagnostic interview, either the Composite International Diagnostic Interview (CIDI) or Structured Clinical Interview for DSM-IV (SCID) to assess the prevalence of formal anxiety disorders in manifest HD carriers. These measures resulted in a lower prevalence compared with the studies based on symptoms with 12.5% (point prevalence), 16.7% (lifetime prevalence) (n=72),²⁴ 16.5% (12-month prevalence) (n=85)²⁵, and 24% (lifetime prevalence) (N=21)²⁶ for any anxiety disorder. One longitudinal study using the CIDI investigated a combined sample of premanifest and manifest HD carriers²⁷ and found a 2-year cumulative prevalence of 17% for all expansion carriers.

Five studies using diagnostic measures reported prevalence ranges from 0% to 17% for premanifest carriers.^25,28–31 The studies reporting that none of their samples fitted diagnostic criteria^29,31 were small studies, whereas another small study (N=26) reported that 11.5% of its sample fitted diagnostic criteria for an anxiety disorder.²⁸ The two studies of premanifest HD expansion carriers with larger sample sizes (N=55 and N=89) reported similar prevalence levels to manifest HD carriers, both using CIDI at 14.5% and 15%.^25,30 The lifetime prevalence was estimated as 17% in the latter study.

One of the diagnostic studies compared manifest and premanifest HD carriers using CIDI and found no statistical difference between the groups for formal diagnoses of panic disorder, agoraphobia without panic, generalized anxiety disorder (GAD), social phobia, and OCD.²⁵ The prevalence of formal anxiety disorders in the manifest HD group compared with the noncarrier group was not statistically significant. Four studies using diagnostic criteria found no difference in the frequency of anxiety disorders between premanifest HD carriers and noncarriers.^25,29–31

Prevalence of individual anxiety disorders.

The prevalence of formal anxiety disorders is provided in Table 3. The disorders that tended to be more prevalent were GAD (3.8%−9%) and panic disorder (3.6%−7.7%). Prevalence estimates for social phobia were 2%−7.5%, and agoraphobia 0%−6%. Simple phobia was only reported in one study with a prevalence of 7%, and posttraumatic stress disorder was not examined.

Correlates and Predictors

A total of 28 studies were identified that examined the relationship between anxiety and sociodemographic, clinical, psychiatric, and psychological factors in HD.

Sociodemographic and Clinical

Age and gender were not found to relate to anxiety.^14,18,26 Four studies that examined the relationship between anxiety and CAG repeat length revealed no association.^23,24,28,32 No relationship was found between anxiety and motor functioning. Measures included degree of chorea, aberrant motor behavior^18,33 and motor compromise as assessed by Folstein’s Quantified Neurological Examination.^23,32 Anxiety was not associated with cognition across three studies, nor was any difference found in anxiety between patients who had dementia (N=11) and did not have dementia (N=18).³¹ In one study, pain was found to be a significant independent predictor of anxiety.²¹

Only one study examined whether anxiety symptoms were related to QoL in HD.³⁴ Using regression analysis, for 48 HD participants, these authors found that anxiety-tension response on the Profile of Mood States (short form) (POMS-SF) made a significant contribution to QoL along with physical symptoms, psychological symptoms, and depression.

Only one study was identified that examined anxiety and general daily functioning in HD. This prospective study examined 960 participants³⁵ who were followed up for a mean duration of 18.3 months. These authors found that severity on a combined factor of depression and anxiety on the UHDRS influenced the rate of decline on the Independence scale of the UHDRS.

Other studies have consistently found no relationship between anxiety and disease duration.^{6,15,18,23,32}

Psychiatric

Several correlation studies using a variety of measures found an association between anxiety and depression.^{18,23,31,36,38} Depression was associated with anxiety in factor analysis studies of the PBA-HD^6,39 and in studies using the behavioral section of the UHDRS.^35,39 On the other hand, a discriminant analysis of depression measures found that the anxiety item of the HAM-D was not good at discriminating between HD patients who were experiencing depressed mood and those who were not, as measured by a single item on the UHDRS.⁴⁰

A positive relationship between anxiety and agitation/irritability among manifest HD participants^18,33,36 was found. Anxiety appeared to be unrelated to apathy across several studies using correlational methods of the NPI^18,37 and factor analysis of the PBA-HD.^6,38

Three studies were identified that examined the relationship between anxiety and suicide, with mixed results. In a regression study, a mixed depression/anxiety factor of the UHDRS data for 1,941 motor symptomatic HD mutation carriers was found to significantly predict suicidal ideation.⁴¹ However, no separate analysis of depression and anxiety was conducted to examine whether there was any independent association between anxiety and suicidal ideation. No independent risk factor for suicidal behavior, defined as suicide or attempted suicide, was found in premanifest individuals in the PREDICT-HD study.⁴² Another study using the UHDRS examined 2,106 HD mutation carriers identified anxiety as being independently associated with suicidal ideation at baseline, but during a 4-year period it was not predictive of suicidal ideation.⁴³

Psychological Variables

One study of manifest HD patients identified a number of illness perceptions and coping styles to be associated with higher levels of anxiety.²¹ A stronger belief in the fluctuation of symptoms, greater illness identity, and a less strong belief in treatment control were related to greater anxiety.²¹ Coping strategies of venting, self-blame, and behavioral disengagement were associated with higher levels of anxiety; a low acceptance of illness was also linked with higher anxiety.²¹

There are mixed results regarding the impact of genetic testing on anxiety levels among HD expansion carriers. Studies by the same authors revealed no differences in pre- and posttest trait anxiety in HD expansion carriers 1 year after predictive genetic testing,^22,44 but there were significant reductions in trait anxiety 5 years after predictive testing and in state anxiety 1 year and 5 years after testing.⁴⁵ One study found no change in anxiety among 35 premanifest carriers 18 months after testing using the UHDRS.¹⁴ The one study that examined the impact of diagnostic DNA testing on those with motor signs demonstrated no change in anxiety scores at 2-week and 3-month follow-ups.⁴⁶

Intervention

Only five studies examined potential effects that a medical or psychosocial intervention might have on anxiety in HD (Table 5). Three studies reported a significant improvement in anxiety postintervention.^47–49 The first one was an open-label study of olanzapine (5-mg dose orally once per day) during 6 months, involving just 10 participants.⁴⁸ Another study involved 29 HD expansion carriers and their caregivers who undertook the Participant Education Program for HD (PEP-HD),⁴⁷ and a third study involved 37 participants who engaged in a range of intensive therapeutic activities during three inpatient stays of 3 weeks across 1 year.⁴⁹ The PEP-HD study involved HD mutation carriers and their caregivers who undertook 8 two-week sessions of 90 minutes’ duration. Groups were divided into those who were motor symptomatic and premotor symptomatic. The program involved encouraging participants to be proactive in finding information about the disease, self-monitoring, undertaking pleasant activities, performing stress-management techniques, developing coping strategies for depression and anxiety, engaging in social communication, and seeking support. The other intensive therapeutic study involved training activities to improve physical and cognitive functioning, activities of daily living, sessions in the gymnasium and/or swimming pool, and assistive technology assessments. Additionally, patient educational sessions and group discussions were provided. Input was provided from the multidisciplinary team for up to 8 hours per day, 5 days per week.

The olanzapine study⁴⁸ used the UHDRS to measure anxiety, whereas the other two studies^47,49 used the HADS. The olanzapine study involved 11 participants at the start of the olanzapine; one dropout resulted in a total of two men and eight women completing the study. One of the remaining male patients discontinued the drug for 2 weeks and was the only patient whose anxiety score increased. The PEP-HD study had a 25% dropout rate for motor symptomatic HD mutation carriers (11 patients and six caregivers). Six out of the 37 participants dropped out during the course of the 1-year intensive therapy study. All three of these studies were not controlled, randomized, or blinded. None of the studies conducted follow-up assessments, so it is unclear whether the improvements were sustained across time. Although the psychosocial interventions demonstrated improvements and potentially no harmful side effects, it is not clear which aspects of the programs may have helped decrease anxiety symptoms.

The only intervention that also examined premanifest HD carriers was the PEP-HD study,⁴⁷ but it did not affect anxiety levels among this group. Two other studies^57,58 involving manifest HD participants did not have a significant impact on anxiety. One trial⁵⁷ examined the effect of ketamine in a double-blind study, but no significant change in anxiety was identified. The second trial⁵⁸ was a randomized, double-blind, placebo-controlled study of pridopidine (ACR16), 50 mg/day. The HADS was used as a secondary measure, with the main focus on cognition, resulting in a nonsignificant trend toward improvement in anxiety after 4 weeks.

Discussion

This is the first systematic attempt to review the status of research into anxiety in HD. Although anxiety is frequently reported in HD, none of the articles identified in this review examined anxiety as the central theme of the study, confirming that anxiety is a relatively neglected area of research within HD. Results of all studies in this review revealed a wider range of prevalence (13%−71%) among manifest HD participants, compared with the range reported in a previous review of psychopathology in HD undertaken in 2007.⁷ This finding was partly due to one study that examined a cumulative prevalence for 3 years resulting in higher anxiety levels (71%) among manifest HD carriers.¹⁵ Also, since 2007, studies using DSM-IV criteria have been published resulting in lower prevalence rates of anxiety.

Although prevalence studies of premanifest HD expansion carriers showed a lower range of anxiety (0%−15%), this outcome appeared to be the result of nearly all of the studies using tight diagnostic criteria and some studies having very small sample sizes.^28,29,31 When studies of premanifest HD carriers with the largest samples available were compared with the manifest group using a formal diagnosis, there was limited difference in prevalence between the groups. This finding is supported by studies that have compared anxiety across manifest and premanifest HD expansion carriers and have found no difference in symptomology and diagnosis.^4,23,25 These findings would appear to indicate that psychiatric problems precede the development of the motor aspect of the disease,^3,5 although the extent to which anxiety is more prevalent in HD carriers compared with the general (non-HD) population is still unclear. The range of total anxiety diagnoses in the larger studies of HD mutation carriers was 12.5%−16.5% for point prevalence to 12-month prevalence. These results may be compared with rates of the general (non-HD) population, as determined by a systematic review of 41 prevalence studies,⁵⁰ where a best estimate of 10.6% was given (with a 95% confidence interval of 7.5%−14.3%) for total anxiety disorders, across a 1-year period. Hence, although anxiety disorders appear to be more prevalent in HD compared with the general population, this cannot be a definitive conclusion without studies involving greater numbers of HD participants. Specific formal anxiety disorders that appear more prevalent in HD are GAD (3.8%−9%) and PD (3.6%−7.7%), with prevalence rates that are higher than in the general population.⁵⁰

The factors that make comparisons of anxiety prevalence difficult across studies are the different measures used, different disease stages of participants, and rather small sample sizes. Many studies of anxiety in HD have used measures that were designed specifically to assess the range of behavioral symptoms in HD, like the PBA-HD, but have limited items for the assessment of anxiety. Hence, the full range of symptoms associated with anxiety problems may not be captured, along with the different anxiety disorders. Some of the measures used cover a range of anxiety symptoms (e.g., STAI, HADS), but their psychometric properties have not been fully explored for use in HD. DSM criteria may be the gold standard used to assess psychiatric diagnoses,⁷ but there may also be limitations due to the co-occurrence of somatic and cognitive problems and reduced insight into HD, particularly in the more advanced stages of the disease.⁵¹ Results from this review would indicate a requirement for more comprehensive measures of anxiety that are both valid and reliable for use within HD.

The results of this review indicate that it is still unclear whether HD expansion carriers experience more anxiety than verified noncarriers with an a priori 50% risk, which is an interesting area of research, as it assists in our understanding of whether the psychosocial factors of being in an HD family and being at risk for HD contribute to the development of anxiety. However, two recent studies with larger sample sizes than previous studies indicated that premanifest carriers reported more anxiety symptoms than noncarriers,^3,4 suggesting that there may be factors specific to having the disease that underlie anxiety in HD. Many noncarriers may be anxious about their future before they have taken the predictive test, but it would appear from the research to date that even when they have received a negative test result, there is no difference in anxiety among those with a positive and negative result up to 5 years after testing.⁴⁵ The possibility exists that as HD expansion carriers become closer to the onset of motor symptoms, anxiety increases, but so far the evidence does not support this.^4,30 More research is required with larger sample sizes.

A number of variables have been examined in relationship to anxiety in HD. Anxiety is associated with depression in HD, although this relationship requires further elucidation because frequently both conditions have been examined together as a cluster of symptoms. Studies of temporal patterns of anxiety and depression in the general population have revealed that although there is evidence of a bidirectional relationship, anxiety disorders often predate depression.⁵² Importantly, anxiety has been found to have an independent association with suicidal ideation in HD, although it was not found to be a predictor across a 4-year longitudinal study.⁴³ However, given that suicide is strongly related to depression and that anxiety may be a risk factor for depression, it is crucial that anxiety be identified and treated effectively within this population. Despite limited evidence, anxiety also appears to be related to QoL³⁴ and aspects of functional ability,³⁵ which would further confirm that this is an important area to address within HD.

Anxiety is also associated with irritability and agitation. This may be due to a number of different explanations such as anxiety arising in response to interpersonal difficulties created by irritability, that both conditions arise as a result of pathological changes associated with HD, or that anxiety arises from cognitive overload and leads to irritability in a person who lacks social cognition or who is impulsive. It would be useful to explore these relationships further.

In contrast, no relationships between anxiety and apathy, CAG repeat length, cognitive ability, motor performance, or disease progression were found. These findings indicate that anxiety does not follow the trajectory of the disease.^8,15 It has been postulated that the peak of anxiety symptoms at around stage 2 of the disease may be indicative of changes that are occurring in the patient’s life associated with increasing loss of independence and/or an increase in pathological changes in the basal ganglia.⁸ Pain was found to independently predict anxiety in HD, and this area is worthy of further exploration in future studies. So far, there is limited research into the sociodemographic factors that might be associated with anxiety in HD, but no relationship with gender or age has been found.

Regarding the literature on interventions for anxiety in HD, this review identified little evidence of well-designed studies that demonstrated an improvement in anxiety in HD after a medical or psychological intervention. Three interventions have yielded promising results: 1) olanzapine; 2) a psychological intervention; and 3) an intensive multidisciplinary program, but none of these methods were controlled or randomized. All of these interventions were not specifically addressing anxiety but were wider studies examining a number of HD symptoms. There is a need for more robust intervention studies that are randomized, controlled, and blinded with a larger number of participants. A single case study of cognitive-behavioral therapy for a premanifest HD carrier revealed significant relief of anxiety,⁵³ and wider trials of this approach could be undertaken among this group, which may enable carriers to develop coping strategies before significant cognitive deficits arise. As relationships between anxiety, illness perceptions, and coping styles are apparent in HD,²¹ more research in this area could help inform psychosocial interventions for HD.

This review had several limitations. First, our review was limited to articles published in English only and the studies included were relatively heterogeneous, which makes comparisons difficult. Some of the studies included in this review did not explicitly state how they determined whether or not participants were anxious. Most studies in this review excluded HD patients with severe dysarthria, dementia, and advanced-stage disease. The experience of anxiety in these groups requires further research, and suitable assessment methods will be needed. The use of caregiver report appears to show good usefulness in assessing psychopathology in advanced-stage HD.⁵¹ Many of the studies included had small sample sizes; hence, larger-scale studies are required. A variety of assessment tools were used in the studies, with many studies using tools limited to just one item on anxiety. The majority of studies included in this review did not report whether the sample was receiving treatment of anxiety or had done so in the past. Of the studies that did report medication use, there was variation in how such use was reported making comparisons difficult. Furthermore, there is also the possibility that anxiety may have resulted as a side effect of psychotropic medication or that medication-induced akathisia may have been erroneously labeled as anxiety.⁵⁴

The majority of studies of anxiety in HD have been restricted to psychometric measures. Future studies may wish to pursue other paradigms such as physiological or neuroimaging measures. The extent to which various (epi)genetic, organic, and environmental factors contribute to anxiety in HD is still unknown. Further research may help determine whether the symptoms are associated with the pathology of the disease itself or whether familial and other psychosocial factors contribute to the development of anxiety. Research examining the onset of anxiety in HD would enable a better understanding of critical points of risk for patients and also premanifest HD expansion carriers. Given the extent of anxiety symptomology found among HD expansion carriers, it is important that an evidence base is established regarding interventions that can be used to treat anxiety in HD. We hope that this review will provide a basis from which future studies may increase our understanding of this often debilitating, but neglected aspect of HD.

Acknowledgments

No grants were received for this study.

References

Walker FO: Huntington’s disease. Lancet 2007; 369:218–228

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Abstract

Methods

Results

Prevalence and Group Comparison Studies

HD-specific measures.

General symptomatology measures of anxiety.

Diagnostic measures.

Prevalence of individual anxiety disorders.

Correlates and Predictors

Sociodemographic and Clinical

Psychiatric

Psychological Variables

Intervention

Discussion

Acknowledgments

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