Addenbrooke’s Cognitive Examination–Third Edition Predicts Neuropsychological Test Performance
Abstract
Objective:
Methods:
Results:
Conclusions:
Methods
Standard Protocol Approvals, Registrations, and Patient Consents
Patient Population
Variable | NC (N=67) | Mild NCD (N=105) | Major NCD (N=45) |
---|---|---|---|
Age (M±SD in years) | 71.1±7.4 | 75.0±6.1 | 76.0±7.7 |
Education (M±SD in years) | 15.5±2.6 | 15.9±2.9 | 15.8±3.4 |
Gender (N) | |||
Men | 37 | 57 | 30 |
Women | 30 | 48 | 15 |
Handedness (% right) | 95.5 | 90.5 | 75.6 |
Neuropsychological Test Battery
ACE-III Subscales Predicting Neuropsychological Test Scores
ACE-III subscale and test | F | df | p | ηp2 | Radj2 |
---|---|---|---|---|---|
Attention and Orientation | |||||
WAIS-IV DSB | 2.12 | 8 | 0.040 | 0.13 | 0.07 |
TMT B | 12.29 | 8 | <0.001 | 0.46 | 0.43 |
Fluency | |||||
COWAT | 12.52 | 12 | <0.001 | 0.58 | 0.53 |
Semantic Fluency | 4.93 | 12 | <0.001 | 0.35 | 0.28 |
Language BNT | 26.11 | 10 | <0.001 | 0.70 | 0.67 |
Memory | |||||
WMS-IV LM I | 3.08 | 16 | <0.001 | 0.32 | 0.21 |
WMS-IV LM II | 5.61 | 16 | <0.001 | 0.46 | 0.38 |
Visuospatial | |||||
WAIS-IV BD | 8.267 | 7 | <0.001 | 0.34 | 0.29 |
Exploratory Analysis: ACE-III Performance by Education
ACE-III subscale and test | F | df | p | ηp2 | Radj2 |
---|---|---|---|---|---|
Attention and Orientation | |||||
WAIS-IV DSB | 2.78 | 7 | 0.013 | 0.20 | 0.13 |
TMT B | 15.57 | 7 | <0.001 | 0.59 | 0.55 |
Fluency | |||||
COWAT | 8.89 | 11 | <0.001 | 0.57 | 0.51 |
Semantic Fluency | 4.00 | 11 | <0.001 | 0.38 | 0.28 |
Language | |||||
BNT | 23.70 | 8 | <0.001 | 0.71 | 0.68 |
Memory | |||||
WMS-IV LM I | 3.55 | 14 | <0.001 | 0.42 | 0.30 |
WMS-IV LM II | 6.13 | 14 | <0.001 | 0.55 | 0.46 |
Visuospatial | |||||
WAIS-IV BD | 7.34 | 7 | <0.001 | 0.40 | 0.35 |
ACE-III subscale and test | F | df | p | ηp2 | Radj2 |
---|---|---|---|---|---|
Attention and Orientation | |||||
WAIS-IV DSB | 0.81 | 8 | 0.589 | 0.16 | −0.04 |
TMT B | 0.98 | 8 | 0.461 | 0.19 | −0.00 |
Fluency | |||||
COWAT | 8.10 | 12 | <0.001 | 0.75 | 0.66 |
Semantic Fluency | 1.36 | 12 | 0.249 | 0.34 | 0.09 |
Language | |||||
BNT | 9.42 | 10 | <0.001 | 0.69 | 0.61 |
Memory | |||||
WMS-IV LM I | 0.90 | 16 | 0.564 | 0.33 | −0.04 |
WMS-IV LM II | 1.27 | 16 | 0.296 | 0.42 | 0.09 |
Visuospatial | |||||
WAIS-IV BD | 1.12 | 7 | 0.372 | 0.18 | 0.02 |
Predicting Neurocognitive Disorders
ACE-III Performance by Group
Results
Patient Demographics
ACE-III Subscales Predicting Neuropsychological Test Scores
Exploratory Analysis: ACE-III Performance by Education
Predicting Neurocognitive Disorders
Overall ACE-III Performance by Group
Discussion
Conclusions
Acknowledgments
Supplementary Material
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