Preliminary Evidence of Efficacy and Target Engagement of Pramipexole in Anhedonic Depression
Abstract
Objective
Method
Results
Conclusions
Highlights
METHODS
Patient Recruitment
% Female | 67% | |
Mean age (SD) | 45.2 (15.7) | |
Mean BMI (SD) | 30.2 (5.2) | |
% Tobacco users | 42% | |
Mean Hs‐CRP, ng/L (SD) | Baseline | Week 10 |
3.8 (4.7) | 2.6 (3.5) | |
% SSRI users | 42% | |
% SNRI users | 50% | |
% NDRI users | 17% | |
% Antipsychotics users | 0% | |
% Mood stabilizers users | 17% | |
% Previously treated with ECT | 33% | |
Anxiety disorder co‐morbidity (%) | 50% | |
Median number of previous antidepressant trials (range) | 5 (2–14) | |
>50% decrease on MADRS, responder (%) | 33% | |
>50% decrease on SHAPS, responder (%) | 25% | |
Mean pramipexole, mg salt/day, at week 10 (SD) | 3.63 mg salt/day (0.70) |
High‐Sensitivity C‐Reactive Protein (hs‐CRP) Assay
Functional Magnetic Resonance Imaging (fMRI) Procedures
Statistics
RESULTS
![image](/cms/10.1176/appi.prcp.20210042/asset/images/rcp21046-fig-0001.png)
![image](/cms/10.1176/appi.prcp.20210042/asset/images/rcp21046-fig-0002.png)
![image](/cms/10.1176/appi.prcp.20210042/asset/images/rcp21046-fig-0003.png)
DISCUSSION
Footnotes
Supplementary Material
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