Is Methylphenidate-Induced Chorea Responsive to Chlorpromazine?

A 6-year-old girl was seen for acute involuntary movements. She had psychomotor developmental delay without a definite diagnosis after an extensive unrevealing investigation. As her parents were first-degree relatives, a genetic basis for her disease was suspected. Clinically, besides late psychological and motor acquisitions, she had discrete macrocephalus, congenital mild ataxia, and hyperactivity. Otherwise healthy, she was not medicated and had no familial history of neurological disease. She had the first 18 mg extended-release methylphenidate pill that morning and went to school, where she was unusually agitated and could not stay quiet, persistently moving the neck, arms, and legs as if she was dancing. Upon examination, she had persistent choreoathetoid movements of orofacial muscles, arms, and legs, with transient dystonic postures of the right arm. There was no clinical improvement when she was treated with biperiden, Chlorpromazine, 6 mg t.i.d. (0.25 mg/kg/day), was attempted at the eighth hour after symptom onset, with immediate decrease of the involuntary movements, which further faded over the next hours leaving the child in the previous neurological state.

Methylphenidate inhibits dopamine reuptake by binding to the dopamine transport complex, 1 leading to increased synaptic dopamine concentration mainly in the striatum. 1 This is believed to be the basis of its ability to induce movement disorders. Nevertheless, this was reported mainly after chronic treatment or high doses. 1, 2 In our patient, acute chorea was induced by a single low-dose methylphenidate extended-release pill, probably revealing a dopaminergic system in its limit of normal function, in what can be called a brain primed to dopaminergic challenge.

Chlorpromazine, a widely used antipsychotic agent, acts by dopaminergic receptor blockade. According to this, the possibility of counterbalancing methylphenidate effect on dopamine at the synaptic level seems attractive. However, Volkow et al. 3 concluded it would be necessary to block over 80% of dopamine receptors with a neuroleptic before methylphenidate effect could be attenuated. This suggests that (a) probably a more rapid recovery would follow a higher chlorpromazine dose; (b) the observed recovery was chlorpromazine independent, as the half-life of this methylphenidate formulation is 12 hours; or (c) chlorpromazine dose was only sufficient because of previous low-dose methylphenidate exposure. We believe that the immediate response ensuing chlorpromazine prescription argues in favor of a specific role for dopamine receptor antagonists in methylphenidate-induced chorea, justifying further trials in clinical practice.