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Clinical & Research News
Published Online: 1 July 2005

TADS Basics

Publication: Psychiatric News
Volume 40, Number 13
https://doi.org/10.1176/pn.40.13.00400002a
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The following is a brief summary of NIMH's Treatment of Adolescents with Depression Study (TADS), for which 12-week outcome data were published in the August 18, 2004, Journal of the American Medical Association.
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Study Design: Randomized, blinded, multicenter comparing the effectiveness of four treatments for adolescent depression:
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Cognitive-behavioral therapy (CBT) alone
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Fluoxetine (Prozac) alone
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Combination of CBT and fluoxetine
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Placebo pill
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Initial Outcomes: Percentage of the 439 adolescent patients who showed significant improvement at 12 weeks with a Clinical Global Impressions–Improvement score of 1 or 2:
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CBT alone group: 43 percent
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Fluoxetine alone group: 61 percent
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Combination group: 71 percent
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Placebo group: 34 percent

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Psychiatric News
Volume 40 • Number 13 • July 1, 2005
Pages: 2

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Published online: 1 July 2005
Published in print: July 1, 2005

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