Full access
Government News
Published Online: 15 April 2005

Letters Outline Adverse Events

Publication: Psychiatric News
Volume 40, Number 8
https://doi.org/10.1176/pn.40.8.00400066a
A letter from Eli Lilly and Co. dated September 28, 2004, to European clinicians stated that a total of 49 adverse events, including eight fatal events, had been reported for Zyprexa IM as of August 31, 2004. Cardiorespiratory depression, hypotension, and bradycardia were among these reported cases.
The letter stated, “A review of the reported fatalities indicates use of Zyprexa IM in a manner that is inconsistent with the Summary of Product Characteristics including excessive dosing and/or inappropriate use of concomitant benzodiazepines and/or other antipsychotics.”
The letter outlines the following recommendations about use of Zyprexa IM:
•
The maximum combined intramuscular and oral daily dose of Zyprexa is 20 mg, with an initial dose of Zyprexa IM 10 mg as a single injection (use lower doses in elderly patients and those with renal or hepatic impairment).
•
A maximum of three injections of Zyprexa IM may be administered in 24 hours. A minimum of two hours should elapse between the first and second injections.
•
Zyprexa IM is intended for short-term use only, for up to a maximum of three consecutive days.
•
Zyprexa IM should not be administered to patients with unstable medical conditions.
•
Patients treated with Zyprexa IM should have heart and respiratory rates, blood pressure, and level of consciousness carefully observed for two to four hours following administration.
•
Simultaneous injection of Zyprexa IM and parenteral benzodiazepines is not recommended.
A similar letter to Canadian clinicians dated September 7, 2004, outlined the following examples of inappropriate use of Zyprexa IM that were reported to Lilly:
•
In one patient, Zyprexa IM was administered in a total daily dose of 30 mg, which is greater than the maximum recommended by the product monograph, along with other medications including intramuscular lorazepam, intramuscular promethazine, chlorpromazine, and promazine.
•
In another patient who committed suicide, Zyprexa IM was administered in a total daily dose of 30 mg, greater than the maximum recommended by the product monograph, followed by Zyprexa tablets in a cumulative dose greater than the maximum recommended by the product monograph.
•
An 82-year-old patient was treated with Zyprexa IM, as well as intramuscular haloperidol and intramuscular lorazepam. This patient also had dementia, for which Zyprexa is not indicated in Canada.

Information & Authors

Information

Published In

Go to Psychiatric News
Psychiatric News
Volume 40 • Number 8 • April 15, 2005
Pages: 66

History

Published online: 15 April 2005
Published in print: April 15, 2005

Authors

Metrics & Citations

Metrics

Citations

Export Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.

For more information or tips please see 'Downloading to a citation manager' in the Help menu.

Format
Citation style
Style
Copy to clipboard
Tips for downloading citations

There are no citations for this item

View Options

View options

Get Access

Login options

Already a subscriber? Access your subscription through your login credentials or your institution for full access to this article.

Personal login Institutional Login Open Athens login

Not a subscriber?

Subscribe Now / Learn More

PsychiatryOnline subscription options offer access to the DSM-5-TR® library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

Media

Figures

Other

Tables

Share

Share

Share article link

Share

×

As described within the American Psychiatric Association (APA)'s Privacy Policy and Terms of Use, this website utilizes cookies, including for the purpose of offering an optimal online experience and services tailored to your preferences. Please read the entire Privacy Policy and Terms of Use. By closing this message, browsing this website, continuing the navigation, or otherwise continuing to use the APA's websites, you confirm that you understand and accept the terms of the Privacy Policy and Terms of Use, including the utilization of cookies.