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Published Online: 2 November 2007

Research Issues That Are Critical in Developing Countries

The following are ethical, social, and cultural issues that need to be addressed regarding scientific research and health programs in developing countries (see Local Collaboration Key to Success of Health Research in Poor Countries):
•. 
Community engagement
Work collaboratively with host communities that share a common goal and interest.
•. 
Public engagement
Provide people with trustworthy information, and elicit and adopt public input.
•. 
Cultural acceptability
Identify and be sensitive to cultural barriers and context.
•. 
Gender
Empower and educate women, who are often subject to abuse, discrimination, and exploitation.
•. 
Post-trial obligations/benefit sharing
Share the benefits of research with the host communities and individual research participants and offer sustained care after completion.
•. 
Collaboration
Collaborate with local public and private sectors and help create sustainable scientific infrastructure.
•. 
Role of civil society organizations
Engage civil society and nongovernmental organizations working with local communities.
•. 
Affordability
Make new technology affordable and ensure equitable delivery.
•. 
Accessibility
Provide adequate equipment, facilities, and staff to ensure accessibility to poor, rural areas.
•. 
Regulations
Balance regulatory oversight and intellectual property protection with meeting peoples' needs in dire health emergencies.
•. 
Collection, management, and storage of tissue samples
Develop guidance on the use of human tissues in research.
•. 
Corruption and poor governance
Beware of corruption and lack of social and political infrastructure as obstacles to accessing new technology.
•. 
Unintended consequences
Consider and address consequences such as unintended promotion of sexual practice due to perceived benefits of vaccination and consequences of genetically modified organisms.
Source: Peter Singer et al., PLoS Medicine, September 2007.

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Published online: 2 November 2007
Published in print: November 2, 2007

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